2JV2
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1CR5
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![BU of 1cr5 by Molmil](/molmil-images/mine/1cr5) | N-TERMINAL DOMAIN OF SEC18P | Descriptor: | 1-ETHYL-PYRROLIDINE-2,5-DIONE, SEC18P (RESIDUES 22 - 210) | Authors: | Babor, S.M, Fass, D. | Deposit date: | 1999-08-13 | Release date: | 1999-12-22 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Sec18p N-terminal domain. Proc.Natl.Acad.Sci.USA, 96, 1999
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4UZR
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2M3X
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9BOQ
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![BU of 9boq by Molmil](/molmil-images/mine/9boq) | Human p97/VCP structure with a triazole inhibitor (NSC799462/dodecamer) | Descriptor: | 3-(2,6-difluoro-4-{[(4P)-5-{[(2S)-hexan-2-yl]sulfanyl}-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Nandi, P, DeVore, K, Chiu, P.-L. | Deposit date: | 2024-05-05 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors. Commun Chem, 7, 2024
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7OAT
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![BU of 7oat by Molmil](/molmil-images/mine/7oat) | Structural basis for targeted p97 remodelling by ASPL as prerequisite for p97 trimethylation by METTL21D | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Petrovic, S, Heinemann, U, Roske, Y. | Deposit date: | 2021-04-20 | Release date: | 2022-08-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.995 Å) | Cite: | Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D. Proc.Natl.Acad.Sci.USA, 120, 2023
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6CHS
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![BU of 6chs by Molmil](/molmil-images/mine/6chs) | Cdc48-Npl4 complex in the presence of ATP-gamma-S | Descriptor: | MAGNESIUM ION, Npl4, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Kim, K.H, Bodnar, N.O, Walz, T, Rapoport, T.A. | Deposit date: | 2018-02-22 | Release date: | 2018-07-04 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nat. Struct. Mol. Biol., 25, 2018
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5EPP
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![BU of 5epp by Molmil](/molmil-images/mine/5epp) | Structural Insights into the Interaction of p97 N-terminus Domain and VBM Motif in Rhomboid Protease, RHBDL4 | Descriptor: | Rhomboid-related protein 4, Transitional endoplasmic reticulum ATPase | Authors: | Lim, J.J, Lee, Y, Ly, T.T, Kang, J.Y, Lee, J.-G, An, J.Y, Youn, H.-S, Park, K.R, Kim, T.G, Yang, J.K, Jun, Y, Eom, S.H. | Deposit date: | 2015-11-12 | Release date: | 2016-09-14 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4. Biochem.J., 473, 2016
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5X4L
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![BU of 5x4l by Molmil](/molmil-images/mine/5x4l) | Crystal structure of the UBX domain of human UBXD7 in complex with p97 N domain | Descriptor: | Transitional endoplasmic reticulum ATPase, UBX domain-containing protein 7 | Authors: | Jiang, T, Li, Z, Wang, Y, Xu, M. | Deposit date: | 2017-02-13 | Release date: | 2017-03-22 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase Biochem. Biophys. Res. Commun., 486, 2017
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2PJH
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![BU of 2pjh by Molmil](/molmil-images/mine/2pjh) | Strctural Model of the p97 N domain- npl4 UBD complex | Descriptor: | Nuclear protein localization protein 4 homolog, Transitional endoplasmic reticulum ATPase | Authors: | Isaacson, R, Pye, V.E, Simpson, S, Meyer, H.H, Zhang, X, Freemont, P. | Deposit date: | 2007-04-16 | Release date: | 2007-05-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Detailed structural insights into the p97-Npl4-Ufd1 interface. J.Biol.Chem., 282, 2007
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8B5R
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![BU of 8b5r by Molmil](/molmil-images/mine/8b5r) | p97-p37-SPI substrate complex | Descriptor: | I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... | Authors: | van den Boom, J, Marini, G, Meyer, H, Saibil, H. | Deposit date: | 2022-09-24 | Release date: | 2023-06-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Structural basis of ubiquitin-independent PP1 complex disassembly by p97. Embo J., 42, 2023
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4RV0
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![BU of 4rv0 by Molmil](/molmil-images/mine/4rv0) | Crystal structure of TN complex | Descriptor: | Nuclear protein localization protein 4 homolog, SULFATE ION, Transitional endoplasmic reticulum ATPase TER94 | Authors: | Hao, Q, Jiao, S, Shi, Z.B, Zhou, Z.C. | Deposit date: | 2014-11-23 | Release date: | 2015-11-25 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Crystal structure of TN complex To be Published
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3TIW
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![BU of 3tiw by Molmil](/molmil-images/mine/3tiw) | Crystal structure of p97N in complex with the C-terminus of gp78 | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase AMFR, Transitional endoplasmic reticulum ATPase | Authors: | Haenzelmann, P, Schindelin, H. | Deposit date: | 2011-08-22 | Release date: | 2011-09-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | The Structural and Functional Basis of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM): MUTUALLY EXCLUSIVE BINDING OF COFACTORS TO THE N-TERMINAL DOMAIN OF p97. J.Biol.Chem., 286, 2011
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8KG2
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8OOI
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![BU of 8ooi by Molmil](/molmil-images/mine/8ooi) | Full composite cryo-EM map of p97/VCP in ADP.Pi state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Cheng, T.C, Sakata, E, Schuetz, A.K. | Deposit date: | 2023-04-05 | Release date: | 2024-01-31 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Characterizing ATP processing by the AAA+ protein p97 at the atomic level. Nat.Chem., 16, 2024
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5IFS
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![BU of 5ifs by Molmil](/molmil-images/mine/5ifs) | Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | Authors: | Roske, Y, Arumughan, A, Heinemann, U, Wanker, E. | Deposit date: | 2016-02-26 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun, 7, 2016
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6HD0
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6IP2
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![BU of 6ip2 by Molmil](/molmil-images/mine/6ip2) | NSF-D1D2 part in the whole 20S complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Vesicle-fusing ATPase | Authors: | Huang, X, Sun, S, Wang, X, Fan, F, Zhou, Q, Sui, S.F. | Deposit date: | 2018-11-01 | Release date: | 2019-04-24 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanistic insights into the SNARE complex disassembly. Sci Adv, 5, 2019
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3HU2
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![BU of 3hu2 by Molmil](/molmil-images/mine/3hu2) | Structure of p97 N-D1 R86A mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Tang, W.-K. | Deposit date: | 2009-06-12 | Release date: | 2010-06-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. Embo J., 29, 2010
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3CF1
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![BU of 3cf1 by Molmil](/molmil-images/mine/3cf1) | Structure of P97/vcp in complex with ADP/ADP.alfx | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Transitional endoplasmic reticulum ATPase | Authors: | Davies, J.M, Delabarre, B, Brunger, A.T, Weis, W.I. | Deposit date: | 2008-03-01 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure, 16, 2008
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3CF2
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![BU of 3cf2 by Molmil](/molmil-images/mine/3cf2) | Structure of P97/vcp in complex with ADP/AMP-PNP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Davies, J.M, Delabarre, B, Brunger, A.T, Weis, W.I. | Deposit date: | 2008-03-01 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure, 16, 2008
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3HU1
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![BU of 3hu1 by Molmil](/molmil-images/mine/3hu1) | Structure of p97 N-D1 R95G mutant in complex with ATPgS | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | Authors: | Tang, W.-K. | Deposit date: | 2009-06-12 | Release date: | 2010-06-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants. Embo J., 29, 2010
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6HD3
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![BU of 6hd3 by Molmil](/molmil-images/mine/6hd3) | Common mode of remodeling AAA ATPases p97/CDC48 by their disassembly cofactors ASPL/PUX1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 48 homolog A, PHOSPHATE ION | Authors: | Heinemann, U, Roske, Y, Banchenko, S, Arumughan, A, Petrovic, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Common Mode of Remodeling AAA ATPases p97/CDC48 by Their Disassembling Cofactors ASPL/PUX1. Structure, 27, 2019
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5KIW
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![BU of 5kiw by Molmil](/molmil-images/mine/5kiw) | p97 ND1-L198W in complex with VIMP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... | Authors: | Tang, W.K, Xia, D. | Deposit date: | 2016-06-17 | Release date: | 2018-03-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.41 Å) | Cite: | Structural basis for nucleotide-modulated p97 association with the ER membrane. Cell Discov, 3, 2017
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3CF3
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![BU of 3cf3 by Molmil](/molmil-images/mine/3cf3) | Structure of P97/vcp in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | Authors: | Davies, J.M, Delabarre, B, Brunger, A.T, Weis, W.I. | Deposit date: | 2008-03-01 | Release date: | 2008-04-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.25 Å) | Cite: | Improved structures of full-length p97, an AAA ATPase: implications for mechanisms of nucleotide-dependent conformational change. Structure, 16, 2008
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