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8PPS
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BU of 8pps by Molmil
Dimeric RbdA EAL, in apo state
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, EAL domain-containing protein, ...
Authors:Cordery, C.R, Maly, M, Walsh, M.A, Tews, I.
Deposit date:2023-07-08
Release date:2024-05-15
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Phosphodiesterase activation in the biofilm dispersal protein RbdA and relationship to the biofilm formation protein PA2072 of similar architecture
To Be Published
8ARV
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BU of 8arv by Molmil
Structure of the EAL domain of BifA from Pseudomonas aeruginosa
Descriptor: Bifunctional diguanylate cyclase/phosphodiesterase, MAGNESIUM ION
Authors:Dias Teixeira, R, Jenal, U, Hiller, S.
Deposit date:2022-08-17
Release date:2023-04-12
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A genetic switch controls Pseudomonas aeruginosa surface colonization.
Nat Microbiol, 8, 2023
7PK5
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BU of 7pk5 by Molmil
Phosphodiesterase PdeL (EAL domain of crystals comprising full-length protein)
Descriptor: Cyclic di-GMP phosphodiesterase PdeL
Authors:Fadel, J, Schirmer, T.
Deposit date:2021-08-25
Release date:2022-09-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Phosphodiesterase PdeL (EAL domain of crystals comprising full-length protein)
To Be Published
6K6T
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BU of 6k6t by Molmil
Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - c-di-IMP bound form
Descriptor: 9-[(1R,6R,8R,9S,10R,15S,17R,18S)-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-17-(6-oxidanylidene-3H-purin-9-yl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]-3H-purin-6-one, CALCIUM ION, EAL domain protein
Authors:Yadav, M, Pal, K, Sen, U.
Deposit date:2019-06-04
Release date:2020-06-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - c-di-IMP bound form
To Be Published
6PWK
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BU of 6pwk by Molmil
Vibrio cholerae LapD S helix-GGDEF-EAL (bound to c-di-GMP)
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), GGDEF and EAL domain-containing protein, MAGNESIUM ION
Authors:Giglio, K.M, Cooley, R.B, Sondermann, H.
Deposit date:2019-07-23
Release date:2019-10-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae.
Mbio, 10, 2019
6PWJ
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BU of 6pwj by Molmil
Vibrio cholerae LapD S helix-GGDEF-EAL (apo)
Descriptor: GGDEF and EAL domain-containing protein, MAGNESIUM ION, TRIETHYLENE GLYCOL
Authors:Giglio, K.M, Cooley, R.B, Sondermann, H.
Deposit date:2019-07-23
Release date:2019-10-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Conserved Regulatory Circuit Controls Large Adhesins in Vibrio cholerae.
Mbio, 10, 2019
6IJ2
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BU of 6ij2 by Molmil
Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - 5'-pGpG bound form
Descriptor: CALCIUM ION, EAL domain protein, RNA (5'-R(P*GP*G)-3')
Authors:Yadav, M, Pal, K, Sen, U.
Deposit date:2018-10-08
Release date:2019-10-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of c-di-GMP/cGAMP degrading phosphodiesterase VcEAL: identification of a novel conformational switch and its implication.
Biochem.J., 476, 2019
6IH1
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BU of 6ih1 by Molmil
Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - c-di-GMP bound form
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, cyclic di nucleotide phoshodiesterase
Authors:Yadav, M, Pal, K, Sen, U.
Deposit date:2018-09-28
Release date:2019-10-02
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of c-di-GMP/cGAMP degrading phosphodiesterase VcEAL: identification of a novel conformational switch and its implication.
Biochem.J., 476, 2019
6IFQ
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BU of 6ifq by Molmil
Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - Apo form
Descriptor: CALCIUM ION, cyclic di nucleotide phoshodiesterase
Authors:Yadav, M, Pal, K, Sen, U.
Deposit date:2018-09-20
Release date:2019-10-02
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of c-di-GMP/cGAMP degrading phosphodiesterase VcEAL: identification of a novel conformational switch and its implication.
Biochem.J., 476, 2019
6IH7
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BU of 6ih7 by Molmil
Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - 3',3'-cGAMP bound form
Descriptor: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, cyclic di nucleotide phoshodiesterase
Authors:Yadav, M, Pal, K, Sen, U.
Deposit date:2018-09-28
Release date:2019-10-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structures of c-di-GMP/cGAMP degrading phosphodiesterase VcEAL: identification of a novel conformational switch and its implication.
Biochem.J., 476, 2019
6HQ4
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BU of 6hq4 by Molmil
Structure of EAL enzyme Bd1971 - cAMP bound form
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6HQ5
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BU of 6hq5 by Molmil
Structure of EAL Enzyme Bd1971 - cAMP and cyclic-di-GMP bound form
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CALCIUM ION, ...
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6HQ7
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BU of 6hq7 by Molmil
Structure of EAL Enzyme Bd1971 - cGMP bound form
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, EAL Enzyme Bd1971, MAGNESIUM ION
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
5YRP
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BU of 5yrp by Molmil
Crystal structure of the EAL domain of Mycobacterium smegmatis DcpA
Descriptor: MAGNESIUM ION, Sensory box/response regulator
Authors:Chen, H.J, li, N, Luo, Y, Jiang, Y.L, Zhou, C.Z, Chen, Y, Li, Q.
Deposit date:2017-11-09
Release date:2018-05-09
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The GDP-switched GAF domain of DcpA modulates the concerted synthesis/hydrolysis of c-di-GMP inMycobacterium smegmatis.
Biochem. J., 475, 2018
5XGE
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BU of 5xge by Molmil
Crystal structure of the PAS-GGDEF-EAL domain of PA0861 from Pseudomonas aeruginosa in complex with cyclic di-GMP
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Uncharacterized protein PA0861
Authors:Liu, C, Liew, C.W, Sreekanth, R, Lescar, J.
Deposit date:2017-04-13
Release date:2017-12-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.
J. Bacteriol., 200, 2018
5XGB
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BU of 5xgb by Molmil
Crystal structure of the PAS-GGDEF-EAL domain of PA0861 from Pseudomonas aeruginosa
Descriptor: Uncharacterized protein
Authors:Liu, C, Liew, C.W, Sreekanth, R, Lescar, J.
Deposit date:2017-04-13
Release date:2017-12-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.
J. Bacteriol., 200, 2018
5XGD
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BU of 5xgd by Molmil
Crystal structure of the PAS-GGDEF-EAL domain of PA0861 from Pseudomonas aeruginosa in complex with GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Uncharacterized protein PA0861
Authors:Liu, C, Liew, C.W, Sreekanth, R, Lescar, J.
Deposit date:2017-04-13
Release date:2017-12-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa.
J. Bacteriol., 200, 2018
5M3C
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BU of 5m3c by Molmil
Structure of the hybrid domain (GGDEF-EAL) of PA0575 from Pseudomonas aeruginosa PAO1 at 2.8 Ang. with GTP and Ca2+ bound to the active site of the GGDEF domain
Descriptor: CALCIUM ION, Diguanylate cyclase, GUANOSINE-5'-TRIPHOSPHATE
Authors:Giardina, G, Brunotti, P, Cutruzzola, F, Rinaldo, S.
Deposit date:2016-10-14
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.
FEBS J., 285, 2018
5MFU
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BU of 5mfu by Molmil
PA3825-EAL Mn-pGpG Structure
Descriptor: Diguanylate phosphodiesterase, GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, ...
Authors:Horrell, S, Bellini, D, Strange, R, Wagner, A, Walsh, M.
Deposit date:2016-11-18
Release date:2017-03-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.
Sci Rep, 7, 2017
5M1T
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BU of 5m1t by Molmil
PaMucR Phosphodiesterase, c-di-GMP complex
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION, MucR Phosphodiesterase
Authors:Hutchin, A, Tews, I, Walsh, M.A.
Deposit date:2016-10-10
Release date:2017-03-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.
Sci Rep, 7, 2017
5MF5
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BU of 5mf5 by Molmil
PA3825-EAL Mg-CdG Structure
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Diguanylate phosphodiesterase, MAGNESIUM ION
Authors:Horrell, S, Bellini, D, Strange, R, Wagner, A, Walsh, M.
Deposit date:2016-11-17
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.
Sci Rep, 7, 2017
4Y9O
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BU of 4y9o by Molmil
PA3825-EAL Metal-Free-Apo Structure - Manganese Co-crystallisation
Descriptor: PA3825-EAL, PHOSPHATE ION
Authors:Bellini, D, Horrell, S, Wagner, A, Strange, R, Walsh, M.A.
Deposit date:2015-02-17
Release date:2016-09-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:MucR and PA3825 EAL-phosphodiesterase domains from Pseudomonas aeruginosa suggest roles for three metals in the active site
To Be Published
4Y9M
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BU of 4y9m by Molmil
PA3825-EAL Metal-Free-Apo Structure
Descriptor: PA3825-EAL, PHOSPHATE ION
Authors:Bellini, D, Horrell, S, Wagner, A, Strange, R, Walsh, M.A.
Deposit date:2015-02-17
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases.
Sci Rep, 7, 2017
4Y9P
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BU of 4y9p by Molmil
PA3825-EAL Ca-CdG Structure
Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, PA3825-EAL
Authors:Bellini, D, Horrell, S, Wagner, A, Strange, R, Walsh, M.A.
Deposit date:2015-02-17
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:MucR and PA3825 EAL-phosphodiesterase domains from Pseudomonas aeruginosa suggest roles for three metals in the active site
To Be Published
4Y9N
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BU of 4y9n by Molmil
PA3825-EAL Metal-Free-Apo Structure - Magnesium Co-crystallisation
Descriptor: PA3825-EAL, PHOSPHATE ION
Authors:Bellini, D, Horrell, S, Wagner, A, Strange, R, Walsh, M.A.
Deposit date:2015-02-17
Release date:2016-03-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structure of PA3825 from P. aeruginosa bound to cyclic di-GMP and pGpG: new insights for a potential three-metal catalytic mechanism of EAL domains
To Be Published

 

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