9FCF
 
 | | Medicago truncatula 5'-ProFAR isomerase (HISN3) D57N mutant in complex with ProFAR | | Descriptor: | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic, CHLORIDE ION, ... | | Authors: | Witek, W, Imiolczyk, B, Ruszkowski, M. | | Deposit date: | 2024-05-15 | | Release date: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structural, kinetic, and evolutionary peculiarities of HISN3, a plant 5'-ProFAR isomerase.
Plant Physiol Biochem., 215, 2024
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9BK2
 | | Crystal structure of Lactate dehydrogenase in complex with 4-((4-(1-methyl-1H-imidazole-2-carbonyl)phenyl)amino)-4-oxo-2-(4-(trifluoromethyl)phenyl)butanoic acid (S-enantiomer, monoclinic P form) | | Descriptor: | (2S)-4-[4-(1-methyl-1H-imidazole-2-carbonyl)anilino]-4-oxo-2-[4-(trifluoromethyl)phenyl]butanoic acid, DIMETHYL SULFOXIDE, L-lactate dehydrogenase A chain, ... | | Authors: | Lovell, S, Cooper, A, Battaile, K.P, Sharma, H. | | Deposit date: | 2024-04-26 | | Release date: | 2024-07-10 | | Last modified: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer.
Eur.J.Med.Chem., 275, 2024
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8ZKK
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9BQ2
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8ZFL
 | | Caenorhabditis elegans ACR-23 in apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Betaine receptor acr-23,Soluble cytochrome b562 | | Authors: | Chen, Q.F, Liu, F.L, Li, T.Y, Gong, H.H, Guo, F, Liu, S. | | Deposit date: | 2024-05-08 | | Release date: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Structural basis of acetylcholine receptor like-23 (ACR-23) activation by anthelmintics monepantel and betaine
To Be Published
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9FCG
 | | Medicago truncatula 5'-ProFAR isomerase (HISN3) D57N mutant in complex with PrFAR | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic, ... | | Authors: | Witek, W, Imiolczyk, B, Ruszkowski, M. | | Deposit date: | 2024-05-15 | | Release date: | 2024-09-04 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Structural, kinetic, and evolutionary peculiarities of HISN3, a plant 5'-ProFAR isomerase.
Plant Physiol Biochem., 215, 2024
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9CPO
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9EME
 | | AL amyloid fibril from the FOR103 light chain | | Descriptor: | lambda 3 immunoglobulin light chain fragment, residues 2-116 | | Authors: | Pfeiffer, P.B, Karimi-Farsijani, S, Kupfer, N, Schmidt, M, Faendrich, M. | | Deposit date: | 2024-03-08 | | Release date: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Light chain mutations contribute to defining the fibril morphology in systemic AL amyloidosis.
Nat Commun, 15, 2024
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9B6H
 | | Cryo-EM structure of the mouse TRPM8 channel in complex with the antagonist TC-I 2014 and the cooling agonist C3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-{7-(trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Yin, Y, Park, C.-G, Zhang, F, Fedor, J, Feng, S, Suo, Y, Im, W, Lee, S.-Y. | | Deposit date: | 2024-03-25 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Sci Adv, 10, 2024
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8ZSP
 | | Cryo-EM structure of the LSD-bound hTAAR1-Gs complex | | Descriptor: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Jiang, K.X, Zheng, Y, Xu, F. | | Deposit date: | 2024-06-05 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules.
Cell Rep, 43, 2024
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9BA4
 | | Full-length cross-linked Contactin 2 (CNTN2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2 | | Authors: | Liu, J.L, Fan, S.F, Ren, G.R, Rudenko, G.R. | | Deposit date: | 2024-04-03 | | Release date: | 2024-07-17 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Molecular mechanism of contactin 2 homophilic interaction.
Structure, 2024
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9C6N
 | | ARP module of the human TIP60 complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... | | Authors: | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | | Deposit date: | 2024-06-07 | | Release date: | 2024-08-21 | | Last modified: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex.
Science, 385, 2024
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9EQ4
 | | Structure of IgE HMM5 bound to FceRIa cryo-EM class 5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, ... | | Authors: | Andersen, G.R, Jensen, R.K. | | Deposit date: | 2024-03-20 | | Release date: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (8.4 Å) | | Cite: | Structure of IgE HMM5 bound to FceRIa cryo-EM class 5
To be published
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9BC2
 | | Transglutaminase 2 - Open State | | Descriptor: | CHLORIDE ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2, ... | | Authors: | Mathews, I.I, Sewa, A, Khosla, C. | | Deposit date: | 2024-04-07 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-17 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9BIT
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 1 | | Descriptor: | CLOXACILLIN, Solute carrier family 15 member 2, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-04-24 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2
To Be Published
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9BTS
 | | Crystal structure of the bacterioferritin (Bfr) and ferritin (Ftn) heterooligomer complex from Acinetobacter baumannii | | Descriptor: | Bacterioferritin (Bfr), Ferritin (Ftn), PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Lovell, S, Liu, L, Battaile, K.P, Rivera, M. | | Deposit date: | 2024-05-15 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The crystal structure of Acinetobacter baumannii bacterioferritin reveals a heteropolymer of bacterioferritin and ferritin subunits.
Sci Rep, 14, 2024
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9BIR
 | | Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cefadroxil | | Descriptor: | Cefadroxil, Solute carrier family 15 member 2, nanobody | | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | | Deposit date: | 2024-04-24 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2
To Be Published
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8ZHG
 | | SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, focused refinement of RBD-Fab region | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, Light chain of R1-26 Fab, ... | | Authors: | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | | Deposit date: | 2024-05-10 | | Release date: | 2024-08-21 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants
To Be Published
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9JA0
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1KJU
 | | Ca2+-ATPase in the E2 State | | Descriptor: | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1a | | Authors: | Xu, C, Rice, W.J, He, W, Stokes, D.L. | | Deposit date: | 2001-12-05 | | Release date: | 2001-12-19 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (6 Å) | | Cite: | A structural model for the catalytic cycle of Ca(2+)-ATPase.
J.Mol.Biol., 316, 2002
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9EQ3
 | | Structure of IgE HMM5 bound to FceRIa cryo-EM class 8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, ... | | Authors: | Andersen, G.R, Jensen, R.K. | | Deposit date: | 2024-03-20 | | Release date: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (6.9 Å) | | Cite: | Structure of IgE HMM5 bound to FceRIa cryo-EM class 8
To be published
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8YOP
 | | Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Li, X, Wang, M, Denk, T, Cheng, J. | | Deposit date: | 2024-03-13 | | Release date: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Nat Commun, 15, 2024
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9FJC
 | | Compact CVB1-VLP (Tween80) | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | Authors: | Plavec, Z, Butcher, S.J. | | Deposit date: | 2024-05-30 | | Release date: | 2024-07-31 | | Method: | ELECTRON MICROSCOPY (2.15 Å) | | Cite: | Comparison of structure and immunogenicity of CVB1-VLP and inactivated CVB1 vaccine candidates.
Res Sq, 2024
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8ZSB
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9BGN
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