6AU2
 
 | | Crystal structure of SETDB1 Tudor domain with aryl triazole fragments | | Descriptor: | 1,2-ETHANEDIOL, 1-methyl-4H,6H-[1,2,4]triazolo[4,3-a][4,1]benzoxazepine, BETA-MERCAPTOETHANOL, ... | | Authors: | MADER, P, Mendoza-Sanchez, R, IQBAL, A, DONG, A, DOBROVETSKY, E, CORLESS, V.B, LIEW, S.K, TEMPEL, W, SMIL, D, DELA SENA, C.C, KENNEDY, S, DIAZ, D, HOLOWNIA, A, VEDADI, M, BROWN, P.J, SANTHAKUMAR, V, Bountra, C, Edwards, A.M, YUDIN, A.K, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | | Deposit date: | 2017-08-30 | | Release date: | 2017-10-11 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Identification and characterization of the first fragment hits for SETDB1 Tudor domain.
Bioorg.Med.Chem., 27, 2019
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1GLP
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1B37
 | | A 30 ANGSTROM U-SHAPED CATALYTIC TUNNEL IN THE CRYSTAL STRUCTURE OF POLYAMINE OXIDASE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FLAVIN-ADENINE DINUCLEOTIDE, PROTEIN (POLYAMINE OXIDASE), ... | | Authors: | Binda, C, Coda, A, Angelini, R, Federico, R, Ascenzi, P, Mattevi, A. | | Deposit date: | 1998-12-17 | | Release date: | 1999-12-17 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase.
Structure Fold.Des., 7, 1999
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1CDW
 | | HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA | | Descriptor: | DNA (5'-D(*CP*AP*GP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*CP*TP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)) | | Authors: | Nikolov, D.B, Chen, H, Halay, E.D, Hoffmann, A, Roeder, R.G, Burley, S.K. | | Deposit date: | 1996-04-11 | | Release date: | 1996-12-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a human TATA box-binding protein/TATA element complex.
Proc.Natl.Acad.Sci.USA, 93, 1996
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1H3Z
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1GVC
 | | 18kDa N-II domain fragment of duck ovotransferrin + NTA | | Descriptor: | CARBONATE ION, FE (III) ION, NITRILOTRIACETIC ACID, ... | | Authors: | Kuser, P, Hall, D.R, Haw, M.L, Neu, M, Lindley, P.F. | | Deposit date: | 2002-02-07 | | Release date: | 2002-02-12 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Mechanism of Iron Uptake by Transferrins: The X-Ray Structures of the 18 kDa Nii Domain Fragment of Duck Ovotransferrin and its Nitrilotriacetate Complex
Acta Crystallogr.,Sect.D, 58, 2002
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1GVM
 | | CHOLINE BINDING DOMAIN OF THE MAJOR AUTOLYSIN (C-LYTA) FROM STREPTOCOCCUS PNEUMONIAE | | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AUTOLYSIN, CHOLINE ION, ... | | Authors: | Fernandez-Tornero, C, Lopez, R, Garcia, E, Gimenez-Gallego, G, Romero, A. | | Deposit date: | 2002-02-15 | | Release date: | 2002-08-01 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Two New Crystal Forms of the Choline-Binding Domain of the Major Pneumococcal Autolysin: Insights Into the Dynamics of the Active Dimeric
J.Mol.Biol., 321, 2002
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3R58
 | | AKR1C3 complex with naproxen | | Descriptor: | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid, 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C3, ... | | Authors: | Yosaatmadja, Y, Teague, R.M, Flanagan, J.U, Squire, C.J. | | Deposit date: | 2011-03-18 | | Release date: | 2012-03-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structures of three classes of non-steroidal anti-inflammatory drugs in complex with aldo-keto reductase 1C3.
Plos One, 7, 2012
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1CQL
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1CQX
 | | Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution | | Descriptor: | 1-[GLYCEROLYLPHOSPHONYL]-2-[8-(2-HEXYL-CYCLOPROPYL)-OCTANAL-1-YL]-3-[HEXADECANAL-1-YL]-GLYCEROL, FLAVIN-ADENINE DINUCLEOTIDE, FLAVOHEMOPROTEIN, ... | | Authors: | Ermler, U, Siddiqui, R.A, Cramm, R, Friedrich, B. | | Deposit date: | 1999-08-12 | | Release date: | 1999-08-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 A resolution.
EMBO J., 14, 1995
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1T0Y
 | | Solution Structure of a Ubiquitin-Like Domain from Tubulin-binding Cofactor B | | Descriptor: | tubulin folding cofactor B | | Authors: | Lytle, B.L, Peterson, F.C, Qui, S.H, Luo, M, Volkman, B.F, Markley, J.L, Center for Eukaryotic Structural Genomics (CESG) | | Deposit date: | 2004-04-13 | | Release date: | 2004-04-27 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of a Ubiquitin-like Domain from Tubulin-binding Cofactor B.
J.Biol.Chem., 279, 2004
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6BFS
 | | The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies | | Descriptor: | Fab Heavy Chain, Fab light Chain, Granulocyte-macrophage colony-stimulating factor | | Authors: | Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W. | | Deposit date: | 2017-10-26 | | Release date: | 2018-09-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
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6BGA
 | | 2B4 I-Ek TCR-MHC complex with affinity-enhancing Velcro peptide | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2B4 peptide,MHC I-Ek B chain, ... | | Authors: | Gee, M.H, Sibener, L.V, Birnbaum, M.E, Jude, K.M, Garcia, K.C. | | Deposit date: | 2017-10-27 | | Release date: | 2018-07-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.307 Å) | | Cite: | Stress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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2I9K
 | | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI | | Descriptor: | 5'-D(*T*GP*AP*TP*AP*GP*CP*GP*CP*TP*AP*TP*C)-3', Modification methylase HhaI, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Youngblood, B, Shieh, F.K, De Los Rios, S, Perona, J.J, Reich, N.O. | | Deposit date: | 2006-09-05 | | Release date: | 2006-10-10 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Engineered Extrahelical Base Destabilization Enhances Sequence Discrimination of DNA Methyltransferase M.HhaI
J.Mol.Biol., 362, 2006
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1ANX
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1A8W
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1ALF
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1H3L
 | | N-terminal fragment of SigR from Streptomyces coelicolor | | Descriptor: | RNA POLYMERASE SIGMA FACTOR | | Authors: | Li, W, Stevenson, C.E.M, Burton, N, Jakimowicz, P, Paget, M.S.B, Buttner, M.J, Lawson, D.M, Kleanthous, C. | | Deposit date: | 2002-09-10 | | Release date: | 2002-10-03 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.375 Å) | | Cite: | Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor
J.Mol.Biol., 323, 2002
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1GQW
 | | Taurine/alpha-ketoglutarate Dioxygenase from Escherichia coli | | Descriptor: | 2-AMINOETHANESULFONIC ACID, 2-OXOGLUTARIC ACID, ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE, ... | | Authors: | Elkins, J.M, Ryle, M.J, Clifton, I.J, Dunning-Hotopp, J.C, Lloyd, J.S, Burzlaff, N.I, Baldwin, J.E, Hausinger, R.P, Roach, P.L. | | Deposit date: | 2001-12-05 | | Release date: | 2002-04-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | X-Ray Crystal Structure of Escherichia Coli Taurine/Alpha-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates
Biochemistry, 41, 2002
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6BCA
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1GYF
 | | GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN | | Descriptor: | PROTEIN (CYTOPLASMIC DOMAIN BINDING PROTEIN (CD2BP2)) | | Authors: | Freund, C, Doetsch, V, Nishizawa, K, Reinherz, E.L, Wagner, G. | | Deposit date: | 1999-04-30 | | Release date: | 2000-01-05 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.
Nat.Struct.Biol., 6, 1999
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1A77
 | | FLAP ENDONUCLEASE-1 FROM METHANOCOCCUS JANNASCHII | | Descriptor: | FLAP ENDONUCLEASE-1 PROTEIN, MAGNESIUM ION | | Authors: | Hwang, K.Y, Baek, K, Kim, H, Cho, Y. | | Deposit date: | 1998-03-20 | | Release date: | 1999-08-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure of flap endonuclease-1 from Methanococcus jannaschii.
Nat.Struct.Biol., 5, 1998
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1YUE
 | | Bacteriophage T4 capsid vertex protein gp24 | | Descriptor: | Head vertex protein Gp24 | | Authors: | Fokine, A, Leiman, P.G, Shneider, M.M, Ahvazi, B, Boeshans, K.M, Steven, A.C, Black, L.W, Mesyanzhinov, V.V, Rossmann, M.G. | | Deposit date: | 2005-02-14 | | Release date: | 2005-04-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural and functional similarities between the capsid proteins of bacteriophages T4 and HK97 point to a common ancestry.
Proc.Natl.Acad.Sci.Usa, 102, 2005
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2OBH
 | | Centrin-XPC peptide | | Descriptor: | CALCIUM ION, Centrin-2, DNA-repair protein complementing XP-C cells | | Authors: | Charbonnier, J.B. | | Deposit date: | 2006-12-19 | | Release date: | 2007-10-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural, thermodynamic, and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein.
J.Mol.Biol., 373, 2007
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1AG2
 | | PRION PROTEIN DOMAIN PRP(121-231) FROM MOUSE, NMR, 2 MINIMIZED AVERAGE STRUCTURE | | Descriptor: | MAJOR PRION PROTEIN | | Authors: | Billeter, M, Riek, R, Wider, G, Wuthrich, K, Hornemann, S, Glockshuber, R. | | Deposit date: | 1997-03-31 | | Release date: | 1997-10-08 | | Last modified: | 2024-06-05 | | Method: | SOLUTION NMR | | Cite: | NMR structure of the mouse prion protein domain PrP(121-231).
Nature, 382, 1996
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