1H3Z

Solution structure of a PWWP domain from Schizosaccharomyces Pombe

Summary for 1H3Z

• Entry DOI: 10.2210/pdb1h3z/pdb
• NMR Information: BMRB: 5538,5902
• Descriptor: HYPOTHETICAL 62.8 KDA PROTEIN C215.07C (1 entity in total)
• Functional Keywords: nuclear protein, pwwp, chromatin, beta-barrel
• Biological source: SCHIZOSACCHAROMYCES POMBE (FISSION YEAST)
• Total number of polymer chains: 1
• Total formula weight: 12210.15

Authors

Slater, L.M.,Allen, M.D.,Bycroft, M. (deposition date: 2002-09-23, release date: 2003-07-10, Last modification date: 2024-05-15)

Primary citation

Slater, L.M.,Allen, M.D.,Bycroft, M.
Structural Variation in Pwwp Domains
J.Mol.Biol., 330:571-576, 2003

PubMed Abstract: The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif.

PubMed: 12842472
DOI: 10.1016/S0022-2836(03)00470-4

Experimental method

SOLUTION NMR