6R5S
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4TXS
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![BU of 4txs by Molmil](/molmil-images/mine/4txs) | An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | Descriptor: | (4-hydroxyphenyl)acetonitrile, Polyprotein | Authors: | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | Deposit date: | 2014-07-07 | Release date: | 2015-05-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
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4TYG
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![BU of 4tyg by Molmil](/molmil-images/mine/4tyg) | Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase | Descriptor: | ACETATE ION, Fibroblast growth factor receptor 4 | Authors: | Lesca, E, Lammens, A, Huber, R, Augustin, M. | Deposit date: | 2014-07-08 | Release date: | 2014-09-24 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426, 2014
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6I7T
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![BU of 6i7t by Molmil](/molmil-images/mine/6i7t) | eIF2B:eIF2 complex | Descriptor: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | Authors: | Adomavicius, T, Guaita, M, Roseman, A.M, Pavitt, G.D. | Deposit date: | 2018-11-17 | Release date: | 2019-05-22 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.61 Å) | Cite: | The structural basis of translational control by eIF2 phosphorylation. Nat Commun, 10, 2019
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6R6K
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![BU of 6r6k by Molmil](/molmil-images/mine/6r6k) | Structure of a FpvC mutant from pseudomonas aeruginosa | Descriptor: | 1,2-ETHANEDIOL, ABC transporter substrate-binding protein, DI(HYDROXYETHYL)ETHER, ... | Authors: | Morera, S, Vigouroux, A. | Deposit date: | 2019-03-27 | Release date: | 2019-07-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A unique ferrous iron binding mode is associated with large conformational changes for the transport protein FpvC of Pseudomonas aeruginosa. Febs J., 287, 2020
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4TYZ
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6R8F
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![BU of 6r8f by Molmil](/molmil-images/mine/6r8f) | Cryo-EM structure of the Human BRISC-SHMT2 complex | Descriptor: | BRISC and BRCA1-A complex member 2,BRCC45 (BRE, BRISC and BRCA1-A complex member 2), BRISC complex subunit Abraxas 2, ... | Authors: | Walden, M, Hesketh, E, Tian, L, Ranson, N.A, Greenberg, R.A, Zeqiraj, E. | Deposit date: | 2019-04-01 | Release date: | 2019-06-05 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Metabolic control of BRISC-SHMT2 assembly regulates immune signalling. Nature, 570, 2019
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6R7X
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![BU of 6r7x by Molmil](/molmil-images/mine/6r7x) | CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-10, CALCIUM ION, ... | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Baronina, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-03-29 | Release date: | 2019-05-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nat Commun, 10, 2019
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6R9J
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![BU of 6r9j by Molmil](/molmil-images/mine/6r9j) | Structure of Saccharomyces cerevisiae apo Pan2 pseudoubiquitin hydrolase-RNA exonuclease (UCH-Exo) module in complex with A7 RNA | Descriptor: | A7 RNA, PAN2-PAN3 deadenylation complex catalytic subunit PAN2 | Authors: | Tang, T.T.L, Stowell, J.A.W, Hill, C.H, Passmore, L.A. | Deposit date: | 2019-04-03 | Release date: | 2019-05-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.326 Å) | Cite: | The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases. Nat.Struct.Mol.Biol., 26, 2019
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6R9P
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![BU of 6r9p by Molmil](/molmil-images/mine/6r9p) | Structure of Saccharomyces cerevisiae apo Pan2 pseudoubiquitin hydrolase-RNA exonuclease (UCH-Exo) module in complex with AAUUAA RNA | Descriptor: | AAUUAA RNA, PAN2-PAN3 deadenylation complex catalytic subunit PAN2 | Authors: | Tang, T.T.L, Stowell, J.A.W, Hill, C.H, Passmore, L.A. | Deposit date: | 2019-04-03 | Release date: | 2019-05-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases. Nat.Struct.Mol.Biol., 26, 2019
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6RDK
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![BU of 6rdk by Molmil](/molmil-images/mine/6rdk) | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 1B, composite map | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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6RE0
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![BU of 6re0 by Molmil](/molmil-images/mine/6re0) | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 2A, monomer-masked refinement | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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4UDJ
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![BU of 4udj by Molmil](/molmil-images/mine/4udj) | Crystal structure of b-1,4-mannopyranosyl-chitobiose phosphorylase at 1.60 Angstrom in complex with beta-D-mannopyranose and inorganic phosphate | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Ladeveze, S, Cioci, G, Potocki-Veronese, G, Tranier, S, Mourey, L. | Deposit date: | 2014-12-10 | Release date: | 2015-05-27 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural Bases for N-Glycan Processing by Mannoside Phosphorylase. Acta Crystallogr.,Sect.D, 71, 2015
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6REP
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![BU of 6rep by Molmil](/molmil-images/mine/6rep) | Cryo-EM structure of Polytomella F-ATP synthase, Primary rotary state 3, composite map | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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4TVA
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![BU of 4tva by Molmil](/molmil-images/mine/4tva) | Universal Pathway for Post-Transfer Editing Reactions: Insight from Crystal structure of TthPheRS with Puromycine | Descriptor: | PHENYLALANINE, PUROMYCIN, Phenylalanine--tRNA ligase alpha subunit, ... | Authors: | Safro, M, Klipcan, L, Tworowski, D, Peretz, M. | Deposit date: | 2014-06-26 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.597 Å) | Cite: | Universal pathway for posttransfer editing reactions: Insights from the crystal structure of TtPheRS with puromycin. Proc.Natl.Acad.Sci.USA, 112, 2015
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6RD5
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![BU of 6rd5 by Molmil](/molmil-images/mine/6rd5) | CryoEM structure of Polytomella F-ATP synthase, focussed refinement of Fo and peripheral stalk, C2 symmetry | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ATP synthase associated protein ASA1, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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8BYN
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![BU of 8byn by Molmil](/molmil-images/mine/8byn) | Chronic traumatic encephalopathy tau filaments with PET ligand flortaucipir | Descriptor: | 7-(6-fluoranylpyridin-3-yl)-5~{H}-pyrido[4,3-b]indole, Microtubule-associated protein tau | Authors: | Shi, Y, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-12-13 | Release date: | 2023-01-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir. J.Mol.Biol., 435, 2023
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6RDD
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![BU of 6rdd by Molmil](/molmil-images/mine/6rdd) | Cryo-EM structure of Polytomella F-ATP synthase, Primary rotary state 2, monomer-masked refinement | Descriptor: | ASA-10: Polytomella F-ATP synthase associated subunit 10, ATP synthase associated protein ASA1, ATP synthase subunit alpha, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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4TY8
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![BU of 4ty8 by Molmil](/molmil-images/mine/4ty8) | An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | Descriptor: | 6-methyl-2H-chromen-2-one, Polyprotein | Authors: | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | Deposit date: | 2014-07-08 | Release date: | 2015-05-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline Sci Rep, 5, 2015
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6RDN
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![BU of 6rdn by Molmil](/molmil-images/mine/6rdn) | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 1C, monomer-masked refinement | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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6RE3
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![BU of 6re3 by Molmil](/molmil-images/mine/6re3) | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 2B, monomer-masked refinement | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ASA-10: Polytomella F-ATP synthase associated subunit 10, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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6R6T
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![BU of 6r6t by Molmil](/molmil-images/mine/6r6t) | Crystal structure of mouse cis-aconitate decarboxylase | Descriptor: | Cis-aconitate decarboxylase | Authors: | Lukat, P, Chen, F, Saile, K, Buessow, K, Pessler, F, Blankenfeldt, W. | Deposit date: | 2019-03-28 | Release date: | 2019-09-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.535 Å) | Cite: | Crystal structure ofcis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc.Natl.Acad.Sci.USA, 116, 2019
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6REU
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![BU of 6reu by Molmil](/molmil-images/mine/6reu) | Cryo-EM structure of Polytomella F-ATP synthase, Rotary substate 3C, focussed refinement of F1 head and rotor | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase gamma chain, ... | Authors: | Murphy, B.J, Klusch, N, Yildiz, O, Kuhlbrandt, W. | Deposit date: | 2019-04-12 | Release date: | 2019-07-03 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Rotary substates of mitochondrial ATP synthase reveal the basis of flexible F 1 -F o coupling. Science, 364, 2019
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6R36
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![BU of 6r36 by Molmil](/molmil-images/mine/6r36) | T. brucei farnesyl pyrophosphate synthase (FPPS) | Descriptor: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase | Authors: | Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. | Deposit date: | 2019-03-19 | Release date: | 2020-04-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase. Chembiochem, 21, 2020
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6R3Z
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![BU of 6r3z by Molmil](/molmil-images/mine/6r3z) | |