PDB: 41522 resultsInfo pagesStatus searchChemie searchBIRD

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8U8K	Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #8 Descriptor: (4M)-4-{(4S)-3-[(2-chloropyridin-3-yl)methyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(oxan-4-yl)pyrimidin-2-amine, Mitogen-activated protein kinase 1 Authors: Anderson, J.W, Vigers, G.P. Deposit date: 2023-09-18 Release date: 2024-03-27 Last modified: 2024-04-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife, 12, 2024
8Y0W	dormant ribosome with eIF5A, eEF2 and SERBP1 Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... Authors: Du, M, Zeng, F. Deposit date: 2024-01-23 Release date: 2024-02-07 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: dormant ribosome with eIF5A, eEF2 and SERBP1 To Be Published
8TL0	Structure of activated SAVED-CHAT filament Descriptor: CHAT domain-containing protein, RNA (5'-R(*AP*AP*A)-3') Authors: Bravo, J.P.K, Taylor, D.W. Deposit date: 2023-07-26 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Type III-B CRISPR-Cas cascade of proteolytic cleavages. Science, 383, 2024
8WDX	Crystal structure of human FABP4 complexed with C3 Descriptor: 1,2-ETHANEDIOL, 2-[(3-chloranyl-2-phenyl-phenyl)amino]-6-methyl-benzoic acid, Fatty acid-binding protein, ... Authors: Xie, H, Chen, G.F, Xu, Y.C. Deposit date: 2023-09-16 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3. Eur.J.Med.Chem., 264, 2023
9ICE	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF DATP (1 MILLIMOLAR) AND CUCL2 (0.1 MILLIMOLAR) Descriptor: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
8XLN	Structure of the SARS-CoV-2 EG.5.1 spike RBD in complex with ACE2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... Authors: Nomai, T, Anraku, Y, Kita, S, Hashiguchi, T, Maenaka, K. Deposit date: 2023-12-26 Release date: 2024-05-01 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.78 Å) Cite: Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant. Microbiol Immunol, 2024
8VQY	Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one, GAMMA-AMINO-BUTANOIC ACID, ... Authors: Chojnacka, W, Teng, J, Kim, J.J, Jensen, A.A, Hibbs, R.E. Deposit date: 2024-01-19 Release date: 2024-06-26 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Structural insights into GABA A receptor potentiation by Quaalude. Nat Commun, 15, 2024
8VE0	Human transthyretin covalently modified with A2-derived stilbene in the compressed conformation Descriptor: 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzoic acid, Transthyretin Authors: Basanta, B, Nugroho, K, Yan, N, Kline, G.M, Tsai, F.J, Wu, M, Kelly, J.W, Lander, G.C. Deposit date: 2023-12-18 Release date: 2024-01-31 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: The conformational landscape of human transthyretin revealed by cryo-EM To Be Published
8VZO	Cryo-EM structure of FLVCR2 in the outward-facing state with choline bound Descriptor: CHOLINE ION, Fab FLV23 heavy chain, Fab FLV23 light chain, ... Authors: Cater, R.J, Mancia, F. Deposit date: 2024-02-12 Release date: 2024-05-01 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.49 Å) Cite: Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature, 629, 2024
8TRN	Actin 1 from T. gondii in filaments bound to MgADP and jasplakinolide Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, Jasplakinolide, ... Authors: Hvorecny, K.L, Sladewski, T.E, Heaslip, A.T, Kollman, J.M. Deposit date: 2023-08-09 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3 Å) Cite: Toxoplasma gondii actin filaments are tuned for rapid disassembly and turnover. Nat Commun, 15, 2024
9ICA	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-O-(1-THIOTRIPHOSPHATE), SOAKED IN THE PRESENCE OF DATP(ALPHA)S AND MNCL2 Descriptor: 2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1995-12-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
9ICL	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX, SOAKED IN THE PRESENCE OF PYROPHOSPHATE AND MNCL2 Descriptor: DNA (5'-D(*CP*AP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*TP*GP*T)-3'), MANGANESE (II) ION, ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1996-01-04 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis Biochemistry, 35, 1996
9ICC	DNA POLYMERASE BETA (E.C.2.7.7.7)/DNA COMPLEX + 2'-DEOXYADENOSINE-5'-TRIPHOSPHATE, SOAKED IN THE PRESENCE OF DATP AND CRCL3 Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CHROMIUM ION, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1995-12-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
8UWU	EmrE structure in the proton-bound state (WT/L51I heterodimer) Descriptor: SMR family multidrug efflux protein EmrE Authors: Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. Deposit date: 2023-11-08 Release date: 2024-05-29 Last modified: 2024-07-03 Method: SOLID-STATE NMR, SOLUTION NMR Cite: Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE. Nat Commun, 15, 2024
9C0O	Crystal structure of DmCfp1 PHD finger bound to H3K4me3 Descriptor: CXXC-type zinc finger protein 1, DIMETHYL SULFOXIDE, Histone H3.3C, ... Authors: Gregoire, S, Couture, J.F. Deposit date: 2024-05-27 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Structural insights into an atypical histone binding mechanism by a PHD finger. to be published
8XGC	Structure of yeast replisome associated with FACT and histone hexamer, Composite map Descriptor: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... Authors: Li, N, Gao, Y, Yu, D, Gao, N, Zhai, Y. Deposit date: 2023-12-15 Release date: 2024-02-14 Last modified: 2024-04-10 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Parental histone transfer caught at the replication fork. Nature, 627, 2024
8WOM	Structure of the wild-type Arabidopsis ABCB19 in the brassinolide-bound state Descriptor: ABC transporter B family member 19, Brassinolide Authors: Ying, W, Wei, H, Liu, X, Sun, L. Deposit date: 2023-10-07 Release date: 2024-03-13 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
8WZK	Human erythrocyte catalase Descriptor: Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE Authors: Yadav, S, Vinothkumar, K.R. Deposit date: 2023-11-01 Release date: 2024-07-10 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Factors affecting macromolecule orientations in thin films formed in cryo-EM. Acta Crystallogr D Struct Biol, 80, 2024
8VBT	Structure of the monofunctional Staphylococcus aureus PBP1 in its apo form Descriptor: Penicillin-binding protein 1 Authors: Bon, C.G, Lee, J, Caveney, N.A, Strynadka, N.C.J. Deposit date: 2023-12-12 Release date: 2024-05-01 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216, 2024
8V1L	Crystal structure of the NTF2L domain of human G3BP1 in complex with small molecule Descriptor: N-[(2S)-2-fluoro-4,4-dimethylpentanoyl]-3-hydroxy-L-valyl-(betaS)-beta-methyl-L-phenylalanyl-D-alanyl-N-benzyl-N,O-dimethyl-L-homoserinamide, Ras GTPase-activating protein-binding protein 1 Authors: Hughes, M.P, Taylor, J.P. Deposit date: 2023-11-20 Release date: 2024-02-14 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Identification of small molecule inhibitors of G3BP-driven stress granule formation. J.Cell Biol., 223, 2024
8WOI	Structure of the wild-type Arabidopsis ABCB19 in the apo state Descriptor: ABC transporter B family member 19 Authors: Ying, W, Wei, H, Liu, X, Sun, L. Deposit date: 2023-10-07 Release date: 2024-03-13 Last modified: 2024-04-03 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
8TLC	Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor Descriptor: N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid, Serine hydroxymethyltransferase, mitochondrial Authors: Katinas, J.M, Dann III, C.E. Deposit date: 2023-07-26 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2. Biochemistry, 2024
8V56	UIC-1 mutant - UIC-1-B5W Descriptor: UIC-1-B5W Authors: Heinz-Kunert, S.L. Deposit date: 2023-11-30 Release date: 2024-03-06 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (0.98 Å) Cite: Pore Restructuring of Peptide Frameworks by Mutations at Distal Packing Residues. Biomacromolecules, 25, 2024
8VE9	IsPETase - ACCCETN mutant - CombiPETase Descriptor: CHLORIDE ION, GLYCEROL, Poly(ethylene terephthalate) hydrolase Authors: Joho, Y, Royan, S, Newton, S, Caputo, A.T, Ardevol Grau, A, Jackson, C. Deposit date: 2023-12-18 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Enhancing PET Degrading Enzymes: A Combinatory Approach. Chembiochem, 25, 2024
9ICJ	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA Descriptor: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), PROTEIN (DNA POLYMERASE BETA (E.C.2.7.7.7)), ... Authors: Pelletier, H, Sawaya, M.R. Deposit date: 1995-12-15 Release date: 1996-11-15 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis Biochemistry, 35, 1996

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