7DLX
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![BU of 7dlx by Molmil](/molmil-images/mine/7dlx) | crystal structure of H2AM4>Z-H2B | Descriptor: | Histone H2B,Histone H2A | Authors: | Dai, L.C, Zhou, Z. | Deposit date: | 2020-11-30 | Release date: | 2021-06-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.395 Å) | Cite: | Recognition of the inherently unstable H2A nucleosome by Swc2 is a major determinant for unidirectional H2A.Z exchange. Cell Rep, 35, 2021
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5A7I
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![BU of 5a7i by Molmil](/molmil-images/mine/5a7i) | Crystal structure of INPP5B in complex with biphenyl 3,3',4,4',5,5'- hexakisphosphate | Descriptor: | Biphenyl 3,3',4,4',5,5'-hexakisphosphate, CHLORIDE ION, GLYCEROL, ... | Authors: | Tresaugues, L, Mills, S.J, Silvander, C, Cozier, G, Potter, B.V.L, Norldund, P. | Deposit date: | 2015-07-06 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family. Biochemistry, 55, 2016
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4ZSQ
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![BU of 4zsq by Molmil](/molmil-images/mine/4zsq) | BACE crystal structure with tricyclic aminothiazine inhibitor | Descriptor: | Beta-secretase 1, GLYCEROL, N-[(4S,4aS,6S,8aR)-10-aminohexahydro-3H-4,8a-(epithiomethenoazeno)isochromen-6(1H)-yl]-3-chlorobenzamide | Authors: | Timm, D.E. | Deposit date: | 2015-05-13 | Release date: | 2015-06-10 | Last modified: | 2015-06-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Preparation and biological evaluation of conformationally constrained BACE1 inhibitors. Bioorg.Med.Chem., 23, 2015
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6E9U
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![BU of 6e9u by Molmil](/molmil-images/mine/6e9u) | The crystal structure of bovine ultralong antibody BOV-7 | Descriptor: | Bovine ultralong antibody BOV-7 heavy chain, Bovine ultralong antibody BOV-7 light chain | Authors: | Dong, J, Crowe, J.E. | Deposit date: | 2018-08-01 | Release date: | 2019-05-01 | Method: | X-RAY DIFFRACTION (2.295 Å) | Cite: | Structural Diversity of Ultralong CDRH3s in Seven Bovine Antibody Heavy Chains. Front Immunol, 10, 2019
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8EZB
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![BU of 8ezb by Molmil](/molmil-images/mine/8ezb) | NHEJ Long-range complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | Authors: | Chen, S, He, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (8.9 Å) | Cite: | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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8EZA
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![BU of 8eza by Molmil](/molmil-images/mine/8eza) | NHEJ Long-range complex with PAXX | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (30-MER), DNA (31-MER), ... | Authors: | Chen, S, He, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (4.39 Å) | Cite: | Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Sci Adv, 9, 2023
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4ZYB
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![BU of 4zyb by Molmil](/molmil-images/mine/4zyb) | High resolution structure of M23 peptidase LytM with substrate analogue | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Grabowska, M, Jagielska, E, Czapinska, H, Bochtler, M, Sabala, I. | Deposit date: | 2015-05-21 | Release date: | 2015-10-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | High resolution structure of an M23 peptidase with a substrate analogue. Sci Rep, 5, 2015
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4ZZ8
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![BU of 4zz8 by Molmil](/molmil-images/mine/4zz8) | X-ray crystal structure of chitosan-binding module 2 in complex with chitotriose derived from chitosanase/glucanase from Paenibacillus sp. IK-5 | Descriptor: | 1,2-ETHANEDIOL, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, Glucanase/chitosanase, ... | Authors: | Shinya, S, Oi, H, Kitaoku, Y, Ohnuma, T, Numata, T, Fukamizo, T. | Deposit date: | 2015-05-22 | Release date: | 2016-04-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Mechanism of chitosan recognition by CBM32 carbohydrate-binding modules from a Paenibacillus sp. IK-5 chitosanase/glucanase Biochem.J., 473, 2016
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4CTD
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![BU of 4ctd by Molmil](/molmil-images/mine/4ctd) | X-ray structure of an engineered OmpG loop6-deletion | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, CHLORIDE ION, OUTER MEMBRANE PROTEIN G | Authors: | Grosse, W, Essen, L.-O. | Deposit date: | 2014-03-13 | Release date: | 2014-08-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure-Based Engineering of a Minimal Porin Reveals Loop- Independent Channel Closure. Biochemistry, 53, 2014
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7DBN
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![BU of 7dbn by Molmil](/molmil-images/mine/7dbn) | HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/M184V/F160M:DNA:dCTP ternary complex | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ... | Authors: | Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. | Deposit date: | 2020-10-21 | Release date: | 2021-08-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations. J.Virol., 95, 2021
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7DFC
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![BU of 7dfc by Molmil](/molmil-images/mine/7dfc) | Crystal of Arrestin2-V2Rpp-3-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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4D7Y
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![BU of 4d7y by Molmil](/molmil-images/mine/4d7y) | Crystal structure of mouse C1QL1 globular domain | Descriptor: | C1Q-RELATED FACTOR, CADMIUM ION, CHLORIDE ION, ... | Authors: | Kakegawa, W, Mitakidis, N, Miura, E, Abe, M, Matsuda, K, Takeo, Y, Kohda, K, Motohashi, J, Takahashi, A, Nagao, S, Muramatsu, S, Watanabe, M, Sakimura, K, Aricescu, A.R, Yuzaki, M. | Deposit date: | 2014-12-01 | Release date: | 2015-01-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Anterograde C1Ql1 Signaling is Required in Order to Determine and Maintain a Single-Winner Climbing Fiber in the Mouse Cerebellum Neuron, 85, 2015
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5AA3
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![BU of 5aa3 by Molmil](/molmil-images/mine/5aa3) | |
4D60
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![BU of 4d60 by Molmil](/molmil-images/mine/4d60) | Structure of a dimeric Plasmodium falciparum profilin mutant | Descriptor: | PROFILIN, SULFATE ION | Authors: | Bhargav, S.P, Vahokoski, J, Kallio, J.P, Torda, A, Kursula, P, Kursula, I. | Deposit date: | 2014-11-07 | Release date: | 2015-06-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Two Independently Folding Units of Plasmodium Profilin Suggest Evolution Via Gene Fusion. Cell.Mol.Life Sci., 72, 2015
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7DBM
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![BU of 7dbm by Molmil](/molmil-images/mine/7dbm) | HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/M184V:DNA:dGTP ternary complex | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ... | Authors: | Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. | Deposit date: | 2020-10-21 | Release date: | 2021-08-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations. J.Virol., 95, 2021
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5A80
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![BU of 5a80 by Molmil](/molmil-images/mine/5a80) | Crystal structure of human JMJD2A in complex with compound 40 | Descriptor: | 1,2-ETHANEDIOL, 2-[5-[2-(3-methoxyphenyl)ethanoylamino]-2-oxidanyl-phenyl]pyridine-4-carboxylic acid, LYSINE-SPECIFIC DEMETHYLASE 4A, ... | Authors: | Nowak, R, Velupillai, S, Krojer, T, Gileadi, C, Johansson, C, Korczynska, M, Le, D.D, Younger, N, Gregori-Puigjane, E, Tumber, A, Iwasa, E, Pollock, S.B, Ortiz Torres, I, Kopec, J, Tallant, C, Froese, S, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Shoichet, B.K, Fujimori, D.G, Oppermann, U. | Deposit date: | 2015-07-11 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Docking and Linking of Fragments to Discover Jumonji Histone Demethylase Inhibitors. J.Med.Chem., 59, 2016
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8F3C
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![BU of 8f3c by Molmil](/molmil-images/mine/8f3c) | Cryo-EM consensus structure of Escherichia coli que-PEC (paused elongation complex) RNA Polymerase minus preQ1 ligand | Descriptor: | DNA (38-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Porta, J.C, Chauvier, A, Deb, I, Ellinger, E, Frank, A.T, Meze, K, Ohi, M.D, Walter, N.G. | Deposit date: | 2022-11-09 | Release date: | 2023-06-21 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand. Nat.Struct.Mol.Biol., 30, 2023
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5AC8
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![BU of 5ac8 by Molmil](/molmil-images/mine/5ac8) | S. enterica HisA with mutations D10G, dup13-15, G102A | Descriptor: | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, SULFATE ION | Authors: | Newton, M, Guo, X, Soderholm, A, Nasvall, J, Andersson, D, Patrick, W, Selmer, M. | Deposit date: | 2015-08-12 | Release date: | 2016-09-28 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.699 Å) | Cite: | Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5A2M
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![BU of 5a2m by Molmil](/molmil-images/mine/5a2m) | Thrombin Inhibitor | Descriptor: | (2S)-1-[(2R)-5-carbamimidamido-2-[(phenylmethyl)sulfonylamino]pentanoyl]-N-[[5-chloranyl-2-(hydroxymethyl)phenyl]methyl]pyrrolidine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Ruehmann, E, Heine, A, Klebe, G. | Deposit date: | 2015-05-20 | Release date: | 2016-06-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Thrombin Inhibition To be Published
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5A2T
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![BU of 5a2t by Molmil](/molmil-images/mine/5a2t) | The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses | Descriptor: | BAMBOO MOSAIC VIRUS, COAT PROTEIN | Authors: | DiMaio, F, Chen, C.C, Yu, X, Frenz, B, Hsu, Y.H, Lin, N.S, Egelman, E.H. | Deposit date: | 2015-05-23 | Release date: | 2015-07-22 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | The Molecular Basis for Flexibility in the Flexible Filamentous Plant Viruses. Nat.Struct.Mol.Biol., 22, 2015
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4CX8
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![BU of 4cx8 by Molmil](/molmil-images/mine/4cx8) | Monomeric pseudorabies virus protease pUL26N at 2.5 A resolution | Descriptor: | PSEUDORABIES VIRUS PROTEASE | Authors: | Zuehlsdorf, M, Werten, S, Palm, G.J, Hinrichs, W. | Deposit date: | 2014-04-04 | Release date: | 2015-05-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin Pul26N, a Herpesvirus Serine Protease. Plos Pathog., 11, 2015
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8EEV
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![BU of 8eev by Molmil](/molmil-images/mine/8eev) | Venezuelan equine encephalitis virus-like particle in complex with Fab SKT-20 | Descriptor: | Coat protein, Fab SKT20 heavy chain, Fab SKT20 light chain | Authors: | Tsybovsky, Y, Pletnev, S, Verardi, R, Roederer, M, Kwong, P.D. | Deposit date: | 2022-09-07 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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6E7D
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![BU of 6e7d by Molmil](/molmil-images/mine/6e7d) | Structure of the inhibitory NKR-P1B receptor bound to the host-encoded ligand, Clr-b | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D, Killer cell lectin-like receptor subfamily B member 1B allele B, ... | Authors: | Balaji, G.R, Rossjohn, J, Berry, R. | Deposit date: | 2018-07-26 | Release date: | 2018-10-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition. Nat Commun, 9, 2018
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5ACW
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![BU of 5acw by Molmil](/molmil-images/mine/5acw) | VIM-2-1, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening | Descriptor: | 4-methyl-5-(trifluoromethyl)-1,2,4-triazole-3-thiol, BETA-LACTAMASE, CHLORIDE ION, ... | Authors: | Christopeit, T, Carlsen, T.J.O, Helland, R, Leiros, H.K.S. | Deposit date: | 2015-08-18 | Release date: | 2015-11-04 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening J.Med.Chem., 58, 2015
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3W07
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![BU of 3w07 by Molmil](/molmil-images/mine/3w07) | |