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3MMZ	CRYSTAL STRUCTURE OF putative HAD family hydrolase from Streptomyces avermitilis MA-4680 Descriptor: CALCIUM ION, CHLORIDE ION, putative HAD family hydrolase Authors: Malashkevich, V.N, Ramagopal, U.A, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2010-04-20 Release date: 2010-04-28 Last modified: 2021-02-10 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis. Biochemistry, 52, 2013
3MI1	Axial Ligand Swapping In Double Mutant Maintains Intradiol-cleavage Chemistry in Protocatechuate 3,4-Dioxygenase Descriptor: BETA-MERCAPTOETHANOL, CHLORIDE ION, FE (III) ION, ... Authors: Purpero, V.M, Lipscomb, J.D. Deposit date: 2010-04-09 Release date: 2011-04-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Axial Ligand Swapping In Double Mutant Maintains Intradiol-cleavage Chemistry in Protocatechuate 3,4-Dioxygenase To be Published
5LJF	Crystal structure of the endo-1,4-glucanase RBcel1 E135A with cellotriose Descriptor: Endoglucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose Authors: Dutoit, R, Collet, L, Galleni, M, Bauvois, C. Deposit date: 2016-07-18 Release date: 2017-08-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.734396 Å) Cite: Glycoside hydrolase family 5: structural snapshots highlighting the involvement of two conserved residues in catalysis. Acta Crystallogr D Struct Biol, 77, 2021
7USF	Mouse mammary tumor virus strand transfer complex intasome Descriptor: CALCIUM ION, Integrase, ZINC ION, ... Authors: Jozwik, I, Lyumkis, D. Deposit date: 2022-04-25 Release date: 2022-08-24 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: B-to-A transition in target DNA during retroviral integration. Nucleic Acids Res., 50, 2022
8UNL	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class A) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNN	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class C) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNR	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class G) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNS	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class H) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNW	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class L) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
7UM3	Crystal structure of a Fab in complex with a peptide derived from the LAG-3 D1 domain loop insertion Descriptor: D1 domain loop peptide from Lymphocyte activation gene 3 protein, Fab heavy chain, Fab light chain Authors: Zorn, J.A, Lee, P.S, Rajpal, A, Strop, P. Deposit date: 2022-04-06 Release date: 2022-09-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.3983 Å) Cite: Preclinical Characterization of Relatlimab, a Human LAG-3-Blocking Antibody, Alone or in Combination with Nivolumab. Cancer Immunol Res, 10, 2022
8UNX	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class M) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UO1	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class Q) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8U1C	A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neuraminidase, mAb-400 heavy chain, ... Authors: Ferguson, J.A, Oeverdieck, S, Ward, A.B. Deposit date: 2023-08-31 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: A mechanistic understanding of protective influenza B neuraminidase mAbs at the airway interface To Be Published
8UNO	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class D) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
5LGE	Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032 Descriptor: 1,2-ETHANEDIOL, 2-[(4-propan-2-ylphenyl)amino]-1-[(1~{S},5~{S})-3,3,5-trimethylcyclohexyl]benzimidazole-5-carboxylic acid, ACETATE ION, ... Authors: Hillig, R.C, Hars, U, Korndoerfer, I.P. Deposit date: 2016-07-07 Release date: 2017-02-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo. Acta Neuropathol., 133, 2017
8UNT	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class I) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNY	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class N) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
5AHF	Crystal structure of Salmonella enterica HisA D7N with ProFAR Descriptor: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, GLYCEROL, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate Authors: Soderholm, A, Guo, X, Newton, M.S, Evans, G.B, Nasvall, J, Patrick, W.M, Selmer, M. Deposit date: 2015-02-05 Release date: 2015-09-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa J.Biol.Chem., 290, 2015
1OY6	Structural Basis of the Multiple Binding Capacity of the AcrB Multidrug Efflux Pump Descriptor: Acriflavine resistance protein B Authors: Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. Deposit date: 2003-04-03 Release date: 2003-05-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.68 Å) Cite: Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
8UNM	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class B) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
7UG9	Crystal structure of RNase AM PHP domain Descriptor: 5'-3' exoribonuclease, MANGANESE (II) ION, SULFATE ION Authors: Doamekpor, S.K, Tong, L. Deposit date: 2022-03-24 Release date: 2022-08-31 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases. Nucleic Acids Res., 50, 2022
1OY8	Structural Basis of Multiple Drug Binding Capacity of the AcrB Multidrug Efflux Pump Descriptor: Acriflavine resistance protein B, RHODAMINE 6G Authors: Yu, E.W, McDermott, G, Zgurskaya, H.I, Nikaido, H, Koshland Jr, D.E. Deposit date: 2003-04-03 Release date: 2003-05-13 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.63 Å) Cite: Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science, 300, 2003
8UNQ	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class F) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNV	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class K) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024
8UNZ	CryoEM structure of beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (Class O) Descriptor: (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol, Beta-2 adrenergic receptor, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Papasergi-Scott, M.M, Skiniotis, G. Deposit date: 2023-10-19 Release date: 2024-03-06 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Time-resolved cryo-EM of G-protein activation by a GPCR. Nature, 629, 2024

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