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4BB2
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BU of 4bb2 by Molmil
Crystal structure of cleaved corticosteroid-binding globulin in complex with progesterone
Descriptor: 1,2-ETHANEDIOL, CORTICOSTEROID-BINDING GLOBULIN, CYSTEINE, ...
Authors:Gardill, B.R, Vogl, M.R, Lin, H, Hammond, G.L, Muller, Y.A.
Deposit date:2012-09-19
Release date:2012-12-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Corticosteroid-Binding Globulin: Structure-Function Implications from Species Differences
Plos One, 7, 2012
2PEE
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BU of 2pee by Molmil
Crystal Structure of a Thermophilic Serpin, Tengpin, in the Native State
Descriptor: GLYCEROL, SULFATE ION, Serine protease inhibitor
Authors:Zhang, Q.W, Buckle, A.M, Whisstock, J.C.
Deposit date:2007-04-02
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The N terminus of the serpin, tengpin, functions to trap the metastable native state.
Embo Rep., 8, 2007
3ZHA
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BU of 3zha by Molmil
Molecular basis for the action of the collagen-specific chaperone Hsp47 SERPINH1 and its structure-specific client recognition.
Descriptor: COLLAGEN MODEL PEPTIDE 18-T8R11, HSP47, SUCCINIC ACID
Authors:Widmer, C, Gebauer, J.M, Baumann, U.
Deposit date:2012-12-20
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Molecular Basis for the Action of the Collagen-Specific Chaperone Hsp47/Serpinh1 and its Structure-Specific Client Recognition.
Proc.Natl.Acad.Sci.USA, 109, 2012
2QUG
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BU of 2qug by Molmil
Crystal structure of alpha-1-antitrypsin, crystal form A
Descriptor: Alpha-1-antitrypsin
Authors:Hansen, G, Morton, C.J, Pearce, M.C, Feil, S.C, Adams, J.J, Parker, M.W, Bottomley, S.P.
Deposit date:2007-08-05
Release date:2008-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
2OL2
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BU of 2ol2 by Molmil
High Resolution Structure of Native PCI in Space Group P21
Descriptor: GLYCEROL, Plasma serine protease inhibitor
Authors:Li, W, Huntington, J.A.
Deposit date:2007-01-18
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of native protein C inhibitor provides insight into its multiple functions.
J.Biol.Chem., 282, 2007
4AQH
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BU of 4aqh by Molmil
Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR 1, TERT-BUTYL 3-[(4-OXO-3H-PYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]AZETIDINE-1-CARBOXYLATE
Authors:Fjellstrom, O, Deinum, J, Sjogren, T, Johansson, C, Geschwindner, S, Nerme, V, Legnehed, A, McPheat, J, Olsson, K, Bodin, C, Gustafsson, D.
Deposit date:2012-04-17
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation
J.Biol.Chem., 288, 2013
2VDX
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BU of 2vdx by Molmil
Crystal Structure of the reactive loop Cleaved Corticosteroid Binding Globulin
Descriptor: CORTICOSTEROID-BINDING GLOBULIN, SODIUM ION
Authors:Zhou, A, Wei, Z, Read, R.J.
Deposit date:2007-10-13
Release date:2008-05-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The S-to-R Transition of Corticosteroid-Binding Globulin and the Mechanism of Hormone Release.
J.Mol.Biol., 380, 2008
2VDY
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BU of 2vdy by Molmil
Crystal structure of the reactive loop cleaved Corticosteroid Binding Globulin complexed with Cortisol
Descriptor: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, CORTICOSTEROID-BINDING GLOBULIN
Authors:Zhou, A, Wei, Z, Read, R.J.
Deposit date:2007-10-13
Release date:2008-05-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The S-to-R Transition of Corticosteroid-Binding Globulin and the Mechanism of Hormone Release.
J.Mol.Biol., 380, 2008
2R9Y
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BU of 2r9y by Molmil
Structure of antiplasmin
Descriptor: Alpha-2-antiplasmin
Authors:Law, R.H.P, Sofian, T, Kan, W.T, Horvath, A.J, Hitchen, C.R, Langendorf, C.G, Buckle, A.M, Whisstock, J.C, Coughlin, P.B.
Deposit date:2007-09-14
Release date:2007-12-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:X-ray crystal structure of the fibrinolysis inhibitor {alpha}2-antiplasmin
Blood, 111, 2008
2RIV
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BU of 2riv by Molmil
Crystal structure of the reactive loop cleaved human Thyroxine Binding Globulin
Descriptor: GLYCEROL, SULFATE ION, Thyroxine-binding globulin
Authors:Zhou, A, Wei, Z, Stanley, P.L.D, Read, R.J, Stein, P.E, Carrell, R.W.
Deposit date:2007-10-12
Release date:2008-10-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins
J.Biol.Chem., 286, 2011
2V95
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BU of 2v95 by Molmil
Structure of Corticosteroid-Binding Globulin in complex with Cortisol
Descriptor: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, CORTICOSTEROID-BINDING GLOBULIN
Authors:Klieber, M.A, Muller, Y.A.
Deposit date:2007-08-21
Release date:2007-09-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Corticosteroid-Binding Globulin: Structural Basis for Steroid Transport and Proteinase-Triggered Release
J.Biol.Chem., 282, 2007
2VH4
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BU of 2vh4 by Molmil
Structure of a loop C-sheet serpin polymer
Descriptor: TENGPIN
Authors:Zhang, Q, Law, R.H.P, Bottomley, S.P, Whisstock, J.C, Buckle, A.M.
Deposit date:2007-11-19
Release date:2008-01-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A Structural Basis for Loop C-Sheet Polymerization in Serpins.
J.Mol.Biol., 376, 2008
5NCU
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BU of 5ncu by Molmil
Structure of the subtilisin induced serpin-type proteinase inhibitor, miropin.
Descriptor: CHLORIDE ION, GLYCEROL, IODIDE ION, ...
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NCT
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BU of 5nct by Molmil
Structure of the trypsin induced serpin-type proteinase inhibitor, miropin.
Descriptor: ASPARTIC ACID, GLYCEROL, SERINE, ...
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5OM6
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BU of 5om6 by Molmil
Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo2: a MMP9-cleavable drug-binding serpin for doxycycline
Descriptor: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CHLORIDE ION, ...
Authors:Schmidt, K, Muller, Y.A.
Deposit date:2017-07-28
Release date:2018-05-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.849 Å)
Cite:Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NCW
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BU of 5ncw by Molmil
Structure of the trypsin induced serpin-type proteinase inhibitor, miropin (V367K/K368A mutant).
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5OM5
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BU of 5om5 by Molmil
Crystal structure of Alpha1-antichymotrypsin variant DBS-I-allo1: an allosterically triggered drug-binding serpin for doxycycline
Descriptor: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CHLORIDE ION
Authors:Schmidt, K, Muller, Y.A.
Deposit date:2017-07-28
Release date:2018-05-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.595 Å)
Cite:Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM2
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BU of 5om2 by Molmil
Crystal structure of Alpha1-antichymotrypsin variant DBS-I1: a drug-binding serpin for doxycycline
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin
Authors:Schmidt, K, Muller, Y.A.
Deposit date:2017-07-28
Release date:2018-05-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM8
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BU of 5om8 by Molmil
Crystal form 2 of Alpha1-antichymotrypsin variant DBS-II-allo: an allosterically modulated drug-binding serpin for doxorubicin
Descriptor: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CHLORIDE ION, ...
Authors:Schmidt, K, Muller, Y.A.
Deposit date:2017-07-28
Release date:2018-05-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM7
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BU of 5om7 by Molmil
Crystal structure of Alpha1-antichymotrypsin variant DBS-II: a drug-binding serpin for doxorubicin
Descriptor: Alpha-1-antichymotrypsin, DOXORUBICIN
Authors:Schmidt, K, Kern, A, Muller, Y.A.
Deposit date:2017-07-28
Release date:2018-05-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.727 Å)
Cite:Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5OM3
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BU of 5om3 by Molmil
Crystal structure of Alpha1-antichymotrypsin variant DBS-I5: a MMP14-cleavable drug-binding serpin for doxycycline
Descriptor: (4S,4AR,5S,5AR,6R,12AS)-4-(DIMETHYLAMINO)-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE, Alpha-1-antichymotrypsin, DI(HYDROXYETHYL)ETHER
Authors:Schmidt, K, Muller, Y.A.
Deposit date:2017-07-28
Release date:2018-05-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5NBU
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BU of 5nbu by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
5NCS
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BU of 5ncs by Molmil
Structure of the native serpin-type proteinase inhibitor, miropin.
Descriptor: Serpin
Authors:Goulas, T, Ksiazek, M, Garcia-Ferrer, I, Mizgalska, D, Potempa, J, Gomis-Ruth, X.
Deposit date:2017-03-06
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:A structure-derived snap-trap mechanism of a multispecific serpin from the dysbiotic human oral microbiome.
J. Biol. Chem., 292, 2017
5NBV
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BU of 5nbv by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
2WY1
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BU of 2wy1 by Molmil
Crystal structure of rat angiotensinogen in P321 space group
Descriptor: ANGIOTENSINOGEN
Authors:Zhou, A, Wei, Z, Carrell, R.W, Read, R.J.
Deposit date:2009-11-11
Release date:2010-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A Redox Switch in Angiotensinogen Modulates Angiotensin Release.
Nature, 468, 2010

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