8THG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8thg by Molmil](/molmil-images/mine/8thg) | Cryo-EM structure of Nav1.7 with RLZ | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Fan, X, Huang, J, Yan, N. | Deposit date: | 2023-07-16 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7NE0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ne0 by Molmil](/molmil-images/mine/7ne0) | Structure of the ternary complex between Netrin-1, Repulsive-Guidance Molecule-B (RGMB) and Neogenin | Descriptor: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Robinson, R.A, Griffiths, S.C, van de Haar, L.L, Malinauskas, T, van Battum, E.Y, Zelina, P, Schwab, R.A, Karia, D, Malinauskaite, L, Brignani, S, van den Munkhof, M, Dudukcu, O, De Ruiter, A.A, Van den Heuvel, D.M.A, Bishop, B, Elegheert, J, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2021-02-02 | Release date: | 2021-03-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling. Cell, 184, 2021
|
|
7Z8U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7z8u by Molmil](/molmil-images/mine/7z8u) | Catalytic subunit HisG R56A mutant from Psychrobacter arcticus ATPPRT (HisGZ) in complex with ATP and PRPP | Descriptor: | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-TRIPHOSPHATE, ATP phosphoribosyltransferase, ... | Authors: | Alphey, M.S, Fisher, G, da Silva, R.G. | Deposit date: | 2022-03-18 | Release date: | 2022-03-30 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation. Nat Commun, 13, 2022
|
|
8OTX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8otx by Molmil](/molmil-images/mine/8otx) | Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in nanodisc | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Yeo, H, Mehta, V, Gulati, A, Drew, D. | Deposit date: | 2023-04-21 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger. Nature, 623, 2023
|
|
8OTW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8otw by Molmil](/molmil-images/mine/8otw) | Cryo-EM structure of Strongylocentrotus purpuratus SLC9C1 in presence of cAMP | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Sperm-specific sodium proton exchanger | Authors: | Yeo, H, Mehta, V, Gulati, A, Drew, D. | Deposit date: | 2023-04-21 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger. Nature, 623, 2023
|
|
8OTQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8otq by Molmil](/molmil-images/mine/8otq) | Cryo-EM structure of Strongylocentrotus purpuratus sperm-specific Na+/H+ exchanger SLC9C1 in GDN | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, PALMITIC ACID, Sperm-specific sodium proton exchanger | Authors: | Yeo, H, Mehta, V, Gulati, A, Drew, D. | Deposit date: | 2023-04-21 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger. Nature, 623, 2023
|
|
8PD8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pd8 by Molmil](/molmil-images/mine/8pd8) | cAMP-bound SpSLC9C1 in lipid nanodiscs, dimer | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-12 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
|
|
8PD3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8pd3 by Molmil](/molmil-images/mine/8pd3) | Ligand-free SpSLC9C1 in lipid nanodiscs, protomer state 2 | Descriptor: | Sperm-specific sodium proton exchanger | Authors: | Kalienkova, V, Peter, M, Rheinberger, J, Paulino, C. | Deposit date: | 2023-06-11 | Release date: | 2023-11-08 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structures of a sperm-specific solute carrier gated by voltage and cAMP. Nature, 623, 2023
|
|
8OMR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8omr by Molmil](/molmil-images/mine/8omr) | Human tRNA guanine transglycosylase (TGT) bound to tRNAAsp | Descriptor: | 9-DEAZAGUANINE, Queuine tRNA-ribosyltransferase accessory subunit 2, Queuine tRNA-ribosyltransferase catalytic subunit 1, ... | Authors: | Sievers, K, Neumann, P, Susac, L, Trowitzsch, S, Tampe, R, Ficner, R. | Deposit date: | 2023-03-31 | Release date: | 2023-12-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase. Structure, 32, 2024
|
|
8OM2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8om2 by Molmil](/molmil-images/mine/8om2) | Small subunit of yeast mitochondrial ribosome in complex with METTL17/Rsm22. | Descriptor: | 15S mitochondrial rRNA, 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial, ... | Authors: | Itoh, Y, Chicherin, I, Kamenski, P, Amunts, A. | Deposit date: | 2023-03-31 | Release date: | 2024-01-10 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | METTL17 is an Fe-S cluster checkpoint for mitochondrial translation. Mol.Cell, 84, 2024
|
|
7NKS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nks by Molmil](/molmil-images/mine/7nks) | Structure of the Hantaan virus Gn glycoprotein ectodomain in complex with Fab HTN-Gn1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein, Fab HTN-Gn1 heavy chain, ... | Authors: | Rissanen, I, Bowden, T.A, Huiskonen, J.T, Stass, R. | Deposit date: | 2021-02-18 | Release date: | 2021-06-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural Basis for a Neutralizing Antibody Response Elicited by a Recombinant Hantaan Virus Gn Immunogen. Mbio, 12, 2021
|
|
5IJQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ijq by Molmil](/molmil-images/mine/5ijq) | Crystal structure of autotaxin (ENPP2) re-refined | Descriptor: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | Authors: | Hausmann, J, Joosten, R.P, Perrakis, A. | Deposit date: | 2016-03-02 | Release date: | 2016-06-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin. J.Struct.Biol., 195, 2016
|
|
1F31
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1f31 by Molmil](/molmil-images/mine/1f31) | |
7MXI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mxi by Molmil](/molmil-images/mine/7mxi) | IgE-Fc in complex with DARPins E2_79 and E3_53 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-IgE Inhibitor E2_79, DARPin E3_53, ... | Authors: | Pennington, L.F, Jardetzky, T.J. | Deposit date: | 2021-05-19 | Release date: | 2021-07-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. J.Allergy Clin.Immunol., 148, 2021
|
|
8EOO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8eoo by Molmil](/molmil-images/mine/8eoo) | Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibodies WRAIR-2063 and WRAIR-2151 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Spike protein S1, ... | Authors: | Jensen, J.L, Sankhala, R.S, Joyce, M.G. | Deposit date: | 2022-10-03 | Release date: | 2023-06-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity. J.Virol., 97, 2023
|
|
8ELO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8elo by Molmil](/molmil-images/mine/8elo) | |
8ELQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8elq by Molmil](/molmil-images/mine/8elq) | |
6XPQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xpq by Molmil](/molmil-images/mine/6xpq) | |
8ELP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8elp by Molmil](/molmil-images/mine/8elp) | |
6XQ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xq4 by Molmil](/molmil-images/mine/6xq4) | |
6XPR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xpr by Molmil](/molmil-images/mine/6xpr) | Human antibody D2 H1-1/H3-1 H3 in complex with the influenza hemagglutinin head domain of A/Texas/50/2012(H3N2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | McCarthy, K.R, Harrison, S.C, Lee, J. | Deposit date: | 2020-07-08 | Release date: | 2021-05-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (4.092 Å) | Cite: | A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. Mbio, 12, 2021
|
|
6XPZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xpz by Molmil](/molmil-images/mine/6xpz) | |
6XQ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xq0 by Molmil](/molmil-images/mine/6xq0) | |
6XQ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xq2 by Molmil](/molmil-images/mine/6xq2) | |
8EO2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8eo2 by Molmil](/molmil-images/mine/8eo2) | Lufaxin a bifunctional inhibitor of complement and coagulation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | Authors: | Andersen, J.F, Strayer, E.C. | Deposit date: | 2022-10-01 | Release date: | 2023-08-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
|
|