PDB: 13252 resultsInfo pagesStatus searchChemie searchBIRD

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5ZLC	Binary complex of human DNA Polymerase Mu with MndGTP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA-directed DNA/RNA polymerase mu, MANGANESE (II) ION, ... Authors: Chang, Y.K, Wu, W.J, Tsai, M.D. Deposit date: 2018-03-27 Release date: 2019-05-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Human DNA Polymerase mu Can Use a Noncanonical Mechanism for Multiple Mn2+-Mediated Functions. J.Am.Chem.Soc., 141, 2019
8RE4	Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 5nt pre-translocated complex Descriptor: DNA (47-MER), DNA (50-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Gao, F, Zhang, X. Deposit date: 2023-12-10 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural basis of sigma 54 displacement and promoter escape in bacterial transcription. Proc.Natl.Acad.Sci.USA, 121, 2024
8RED	Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 8nt complex Descriptor: DNA (46-MER), DNA (51-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Gao, F, Zhang, X. Deposit date: 2023-12-10 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis of sigma 54 displacement and promoter escape in bacterial transcription. Proc.Natl.Acad.Sci.USA, 121, 2024
8REE	Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 9nt complex Descriptor: DNA (45-MER), DNA (49-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Gao, F, Zhang, X. Deposit date: 2023-12-10 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis of sigma 54 displacement and promoter escape in bacterial transcription. Proc.Natl.Acad.Sci.USA, 121, 2024
8REC	Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 7nt complex Descriptor: DNA (46-MER), DNA (51-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Gao, F, Zhang, X. Deposit date: 2023-12-10 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural basis of sigma 54 displacement and promoter escape in bacterial transcription. Proc.Natl.Acad.Sci.USA, 121, 2024
8REB	Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 6nt complex Descriptor: DNA (43-MER), DNA (52-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Gao, F, Zhang, X. Deposit date: 2023-12-10 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of sigma 54 displacement and promoter escape in bacterial transcription. Proc.Natl.Acad.Sci.USA, 121, 2024
8REA	Cryo-EM structure of bacterial RNA polymerase-sigma54 initial transcribing complex - 5nt post-translocated complex Descriptor: DNA (44-MER), DNA (51-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Gao, F, Zhang, X. Deposit date: 2023-12-10 Release date: 2024-01-17 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of sigma 54 displacement and promoter escape in bacterial transcription. Proc.Natl.Acad.Sci.USA, 121, 2024
6GO5	TdT chimera (Loop1 of pol mu) - Ternary complex with 1-nt gapped DNA substrate Descriptor: 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (5'-D(*AP*CP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*GP*GP*CP*AP*AP*AP*CP*A)-3'), ... Authors: Loc'h, J, Gerodimos, C.A, Rosario, S, Lieber, M.R, Delarue, M. Deposit date: 2018-06-01 Release date: 2019-06-05 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction. J.Biol.Chem., 294, 2019
6GO6	TdT chimera (Loop1 of pol mu) - ternary complex with downstream dsDNA Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*AP*AP*AP*C)-3'), DNA (5'-D(*TP*TP*TP*TP*TP*GP*GP*C)-3'), ... Authors: Loc'h, J, Gerodimos, C.A, Rosario, S, Lieber, M.R, Delarue, M. Deposit date: 2018-06-01 Release date: 2019-06-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Structural evidence for an intransbase selection mechanism involving Loop1 in polymerase mu at an NHEJ double-strand break junction. J.Biol.Chem., 294, 2019
6EVK	Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ... Authors: Pflug, A, Cusack, S. Deposit date: 2017-11-01 Release date: 2017-12-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018
5W1S	X-ray crystal structure of Escherichia coli RNA polymerase and TraR complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S, Molodtsov, V. Deposit date: 2017-06-04 Release date: 2017-06-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.805 Å) Cite: Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA. Mol. Cell, 69, 2018
7AHO	RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34 Descriptor: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 Authors: Lopez-Perrote, A, Rodriguez, C.F, Llorca, O. Deposit date: 2020-09-25 Release date: 2020-11-25 Method: ELECTRON MICROSCOPY (4.18 Å) Cite: Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. Elife, 9, 2020
6FBV	Single particle cryo em structure of Mycobacterium tuberculosis RNA polymerase in complex with Fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Das, K, Lin, W, Ebright, E. Deposit date: 2017-12-19 Release date: 2018-02-28 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
5AIM	Crystal structure of T138 central eWH domain Descriptor: GLYCEROL, TRANSCRIPTION FACTOR TAU 138 KDA SUBUNIT Authors: Male, G, Glatt, S, Mueller, C.W. Deposit date: 2015-02-16 Release date: 2015-06-24 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.401 Å) Cite: Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly. Nat Commun, 6, 2015
7YOT	Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus Descriptor: NDV P protein, RNA-directed RNA polymerase L Authors: Chen, Y, Jingyuan, C. Deposit date: 2022-08-02 Release date: 2023-02-15 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein. Nat Commun, 14, 2023
7YOU	Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus Descriptor: NDV P protein, RNA-directed RNA polymerase L Authors: Chen, Y, Jingyuan, C, Xiaoying, F. Deposit date: 2022-08-02 Release date: 2023-02-15 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein. Nat Commun, 14, 2023
7YOV	Cryo-EM structure of RNA polymerase in complex with P protein tetramer of Newcastle disease virus Descriptor: NDV P protein, RNA-directed RNA polymerase L Authors: Chen, Y, Jingyuan, C, Xiaoying, F. Deposit date: 2022-08-02 Release date: 2023-02-15 Last modified: 2023-08-30 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Structure of the Newcastle Disease Virus L protein in complex with tetrameric phosphoprotein. Nat Commun, 14, 2023
2A6H	Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-07-02 Release date: 2005-09-20 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis of transcription inhibition by antibiotic streptolydigin. Mol.Cell, 19, 2005
6P1T	Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and bound CMPCPP Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... Authors: Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. Deposit date: 2019-05-20 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
6P1W	Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-nt gapped substrate containing undamaged template dG and bound incoming CMPCPP Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ... Authors: Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. Deposit date: 2019-05-20 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.751 Å) Cite: Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
6P1N	Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and bound incoming dAMPNPP Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. Deposit date: 2019-05-20 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
6P1P	Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and bound incoming dCMPNPP Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. Deposit date: 2019-05-20 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
6P1V	Pre-catalytic ternary complex of human DNA Polymerase Mu with 1-nt gapped substrate containing undamaged template dG and bound incoming dCMPNPP Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. Deposit date: 2019-05-20 Release date: 2019-09-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine. Nucleic Acids Res., 47, 2019
5VO8	X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*CP*TP*GP*AP*TP*GP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Murakami, K.S, Shin, Y, Turnbough Jr, C.L, Molodtsov, V. Deposit date: 2017-05-02 Release date: 2017-05-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.3 Å) Cite: X-ray crystal structure of a reiterative transcription complex reveals an atypical RNA extension pathway. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4EP7	Functional implications from the Cid1 poly(U) polymerase crystal structure Descriptor: MAGNESIUM ION, Poly(A) RNA polymerase protein cid1, URIDINE 5'-TRIPHOSPHATE Authors: Munoz-Tello, P, Gabus, C, Thore, S. Deposit date: 2012-04-17 Release date: 2012-06-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2805 Å) Cite: Functional implications from the cid1 poly(u) polymerase crystal structure. Structure, 20, 2012

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