4JIB
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![BU of 4jib by Molmil](/molmil-images/mine/4jib) | Crystal structure of of PDE2-inhibitor complex | Descriptor: | 1-(2-hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8(1H)-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Pandit, J. | Deposit date: | 2013-03-05 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, Part I: Transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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2A1W
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![BU of 2a1w by Molmil](/molmil-images/mine/2a1w) | Anti-cocaine antibody 7.5.21, crystal form I | Descriptor: | SULFATE ION, immunoglobulin heavy chain, immunoglobulin light chain kappa | Authors: | Pozharski, E, Hewagama, A, Shanafelt, A, Ringe, D, Petsko, G.A. | Deposit date: | 2005-06-21 | Release date: | 2005-06-28 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Flexibility Of Packing:
Four Crystal Forms Of An Anti-Cocaine Antibody 7.5.21 To be Published
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2A83
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![BU of 2a83 by Molmil](/molmil-images/mine/2a83) | Crystal structure of hla-b*2705 complexed with the glucagon receptor (gr) peptide (residues 412-420) | Descriptor: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | Authors: | Ruckert, C, Fiorillo, M.T, Loll, B, Moretti, R, Biesiadka, J, Saenger, W, Ziegler, A, Sorrentino, R, Uchanska-Ziegler, B. | Deposit date: | 2005-07-07 | Release date: | 2005-12-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Conformational dimorphism of self-peptides and molecular mimicry in a disease-associated HLA-B27 subtype. J.Biol.Chem., 281, 2006
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2A4K
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![BU of 2a4k by Molmil](/molmil-images/mine/2a4k) | 3-Oxoacyl-[acyl carrier protein] reductase from Thermus thermophilus TT0137 | Descriptor: | 3-oxoacyl-[acyl carrier protein] reductase, UNKNOWN ATOM OR ION | Authors: | Zhou, W, Ebihara, A, Tempel, W, Yokoyama, S, Chen, L, Kuramitsu, S, Nguyen, J, Chang, S.-H, Liu, Z.-J, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-06-29 | Release date: | 2006-01-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | 3-Oxoacyl-[acyl carrier protein] reductase from Thermus thermophilus TT0137 To be Published
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4IYB
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![BU of 4iyb by Molmil](/molmil-images/mine/4iyb) | Macrolepiota procera ricin B-like lectin (MPL) in complex with galactose | Descriptor: | GLYCEROL, Ricin B-like lectin, beta-D-galactopyranose | Authors: | Renko, M, Zurga, S, Sabotic, J, Pohleven, J, Kos, J, Turk, D. | Deposit date: | 2013-01-28 | Release date: | 2013-11-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Macrolepiota procera ricin B-like lectin (MPL) in complex with galactose To be Published
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4J3W
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![BU of 4j3w by Molmil](/molmil-images/mine/4j3w) | Crystal structure of barley limit dextrinase (E510A mutant) in complex with a branched maltohexasaccharide | Descriptor: | CALCIUM ION, IODIDE ION, Limit dextrinase, ... | Authors: | Sim, L, Windahl, M.S, Moeller, M.S, Henriksen, A. | Deposit date: | 2013-02-06 | Release date: | 2014-02-12 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Oligosaccharide and substrate binding in the starch debranching enzyme barley limit dextrinase J.Mol.Biol., 427, 2015
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4IX2
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![BU of 4ix2 by Molmil](/molmil-images/mine/4ix2) | Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP | Descriptor: | INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase, POTASSIUM ION | Authors: | Osipiuk, J, Maltseva, N, Makowska-Grzyska, M, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-01-24 | Release date: | 2013-02-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.146 Å) | Cite: | Inosine 5'-monophosphate dehydrogenase from Vibrio cholerae, deletion mutant, complexed with IMP. To be Published
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4IZG
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![BU of 4izg by Molmil](/molmil-images/mine/4izg) | Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product) | Descriptor: | (2S,4S)-2-carboxy-4-hydroxy-1,1-dimethylpyrrolidinium, IODIDE ION, MAGNESIUM ION, ... | Authors: | Vetting, M.W, Toro, R, Bhosle, R, Wasserman, S.R, Morisco, L.L, Sojitra, S, Chamala, S, Kar, A, LaFleur, J, Villigas, G, Evans, B, Hammonds, J, Gizzi, A, Stead, M, Hillerich, B, Love, J, Seidel, R.D, Bonanno, J.B, Gerlt, J.A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-01-29 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine. MBio, 5, 2014
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2ABJ
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![BU of 2abj by Molmil](/molmil-images/mine/2abj) | Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate. | Descriptor: | Branched-chain-amino-acid aminotransferase, cytosolic, N'-(5-CHLOROBENZOFURAN-2-CARBONYL)-2-(TRIFLUOROMETHYL)BENZENESULFONOHYDRAZIDE, ... | Authors: | Ohren, J.F, Moreland, D.W, Rubin, J.R, Hu, H.L, McConnell, P.C, Mistry, A, Mueller, W.T, Scholten, J.D, Hasemann, C.H. | Deposit date: | 2005-07-15 | Release date: | 2006-06-27 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg.Med.Chem.Lett., 16, 2006
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1YYP
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![BU of 1yyp by Molmil](/molmil-images/mine/1yyp) | Crystal structure of cytomegalovirus UL44 bound to C-terminal peptide from CMV UL54 | Descriptor: | 1,2-ETHANEDIOL, DNA polymerase, DNA polymerase processivity factor, ... | Authors: | Appleton, B.A, Brooks, J, Loregian, A, Filman, D.J, Coen, D.M, Hogle, J.M. | Deposit date: | 2005-02-25 | Release date: | 2005-12-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44. J.Biol.Chem., 281, 2006
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1Z27
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![BU of 1z27 by Molmil](/molmil-images/mine/1z27) | Crystal structure of Native Pvs25, an ookinete protein from Plasmodium vivax. | Descriptor: | ookinete surface protein Pvs25 | Authors: | Saxena, A.K, Singh, K, Su, H.P, Klein, M.M, Stowers, A.W, Saul, A.J, Long, C.A, Garboczi, D.N. | Deposit date: | 2005-03-07 | Release date: | 2005-12-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms Nat.Struct.Mol.Biol., 13, 2006
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1Z3E
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![BU of 1z3e by Molmil](/molmil-images/mine/1z3e) | Crystal Structure of Spx in Complex with the C-terminal Domain of the RNA Polymerase Alpha Subunit | Descriptor: | DNA-directed RNA polymerase alpha chain, Regulatory protein spx, SULFATE ION | Authors: | Newberry, K.J, Nakano, S, Zuber, P, Brennan, R.G. | Deposit date: | 2005-03-11 | Release date: | 2005-10-11 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the {alpha} C-terminal domain of RNA polymerase Proc.Natl.Acad.Sci.Usa, 102, 2005
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1Z4X
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![BU of 1z4x by Molmil](/molmil-images/mine/1z4x) | Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) with ligand Sialyllactose (soaked with Sialyllactose, pH8.0) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Yuan, P, Thompson, T.B, Wurzburg, B.A, Paterson, R.G, Lamb, R.A, Jardetzky, T.S. | Deposit date: | 2005-03-16 | Release date: | 2005-05-24 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose. Structure, 13, 2005
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4IWY
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![BU of 4iwy by Molmil](/molmil-images/mine/4iwy) | SeMet-substituted RimK structure | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, GLUTAMIC ACID, Ribosomal protein S6 modification protein, ... | Authors: | Shi, D, Zhao, G, Jin, Z, Allewell, N.M, Tuchman, M. | Deposit date: | 2013-01-24 | Release date: | 2013-05-08 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure and function of Escherichia coli RimK, an ATP-grasp fold, l-glutamyl ligase enzyme. Proteins, 81, 2013
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1Z9T
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![BU of 1z9t by Molmil](/molmil-images/mine/1z9t) | |
1YXT
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![BU of 1yxt by Molmil](/molmil-images/mine/1yxt) | Crystal Structure of Kinase Pim1 in complex with AMPPNP | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Proto-oncogene serine/threonine-protein kinase Pim-1 | Authors: | Kumar, A, Mandiyan, V, Suzuki, Y, Zhang, C, Rice, J, Tsai, J, Artis, D.R, Ibrahim, P, Bremer, R. | Deposit date: | 2005-02-22 | Release date: | 2005-04-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma. J.Mol.Biol., 348, 2005
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1ZBT
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4J28
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![BU of 4j28 by Molmil](/molmil-images/mine/4j28) | Crystal structure of a gh29 alpha-l-fucosidase gh29 from bacteroides thetaiotaomicron in complex with a 5-membered iminocyclitol inhibitor | Descriptor: | (2S,3S,4R,5S)-2-(1H-benzimidazol-2-yl)-5-methylpyrrolidine-3,4-diol, Alpha-L-fucosidase, GLYCEROL, ... | Authors: | Wright, D.W. | Deposit date: | 2013-02-04 | Release date: | 2013-05-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Three dimensional structure of a bacterial alpha-l-fucosidase with a 5-membered iminocyclitol inhibitor. Bioorg.Med.Chem., 21, 2013
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1ZDF
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![BU of 1zdf by Molmil](/molmil-images/mine/1zdf) | Ser162 mutant of glycogenin complexed with UDP-glucose and manganese | Descriptor: | Glycogenin-1, MANGANESE (II) ION, SULFATE ION, ... | Authors: | Hurley, T.D, Stout, S.L, Miner, E, Zhou, J, Roach, P.J. | Deposit date: | 2005-04-14 | Release date: | 2005-04-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Requirements for catalysis in mammalian glycogenin. J.Biol.Chem., 280, 2005
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4J2W
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![BU of 4j2w by Molmil](/molmil-images/mine/4j2w) | Crystal Structure of kynurenine 3-monooxygenase (KMO-396Prot-Se) | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Kynurenine 3-monooxygenase | Authors: | Amaral, M, Levy, C, Heyes, D.J, Lafite, P, Outeiro, T.F, Giorgini, F, Leys, D, Scrutton, N.S. | Deposit date: | 2013-02-05 | Release date: | 2013-04-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of kynurenine 3-monooxygenase inhibition. Nature, 496, 2013
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4J4J
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4ISO
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![BU of 4iso by Molmil](/molmil-images/mine/4iso) | Crystal Structure of Matriptase in complex with its inhibitor HAI-1 | Descriptor: | DI(HYDROXYETHYL)ETHER, GLUTATHIONE, GLYCEROL, ... | Authors: | Huang, M.D, Zhao, B.Y, Yuan, C, Li, R. | Deposit date: | 2013-01-16 | Release date: | 2013-03-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem., 288, 2013
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4IRW
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![BU of 4irw by Molmil](/molmil-images/mine/4irw) | Co-crystallization of streptavidin-biotin complex with a lanthanide-ligand complex gives rise to a novel crystal form | Descriptor: | BIOTIN, PYRIDINE-2,6-DICARBOXYLIC ACID, SODIUM ION, ... | Authors: | Bandara, R.A.M.S.S, Liu, D.Q, Hindupur, A, Tesh, K.F, Fox, R.O. | Deposit date: | 2013-01-15 | Release date: | 2014-01-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.396 Å) | Cite: | Co-crystallization of streptavidin-biotin complex with a lanthanide-ligand complex gives rise to a novel crystal form To be Published
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1ZHL
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![BU of 1zhl by Molmil](/molmil-images/mine/1zhl) | Crystal structure of HLA-B*3508 presenting 13-mer EBV antigen LPEPLPQGQLTAY | Descriptor: | Beta-2-microglobulin, EBV-peptide LPEPLPQGQLTAY, HLA class I histocompatibility antigen, ... | Authors: | Tynan, F.E, Borg, N.A, Miles, J.J, Beddoe, T, El-Hassen, D, Silins, S.L, van Zuylen, W.J, Purcell, A.W, Kjer-Nielsen, L, McCluskey, J, Burrows, S.R, Rossjohn, J. | Deposit date: | 2005-04-26 | Release date: | 2005-05-17 | Last modified: | 2014-04-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The high resolution structures of highly bulged viral epitopes bound to the major histocompatability class I: Implications for T-cell receptor engagement and T-cell immunodominance J.Biol.Chem., 280, 2005
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4ISV
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![BU of 4isv by Molmil](/molmil-images/mine/4isv) | Crystal structure of the Fab FRAGMENT OF 1C2, A MONOCLONAL ANTIBODY SPECIFIC FOR POLY-GLUTAMINE | Descriptor: | 1C2 FAB HEAVY CHAIN, 1C2 FAB LIGHT CHAIN | Authors: | Klein, F.A.C, Zeder-Lutz, G, Cousido-Siah, A, Mitschler, A, Katz, A, Eberling, P, Mandel, J.L, Podjarny, A, Trottier, Y. | Deposit date: | 2013-01-17 | Release date: | 2013-07-03 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.497 Å) | Cite: | Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10. Hum.Mol.Genet., 22, 2013
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