1Z27

Crystal structure of Native Pvs25, an ookinete protein from Plasmodium vivax.

Summary for 1Z27

Entry DOI	10.2210/pdb1z27/pdb
Descriptor	ookinete surface protein Pvs25 (2 entities in total)
Functional Keywords	four egf-like domains, cell adhesion
Biological source	Plasmodium vivax (malaria parasite P. vivax)
Total number of polymer chains	1
Total formula weight	20548.25
Authors	Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N. (deposition date: 2005-03-07, release date: 2005-12-06, Last modification date: 2024-10-09)
Primary citation	Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N. The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms Nat.Struct.Mol.Biol., 13:90-91, 2006 Cited by PubMed Abstract: P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle. PubMed: 16327807 DOI: 10.1038/nsmb1024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation