1WW3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ww3 by Molmil](/molmil-images/mine/1ww3) | Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase | Descriptor: | Glycogen phosphorylase, muscle form, N-(trifluoroacetyl)-beta-D-glucopyranosylamine, ... | Authors: | Anagnostou, E, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Hadjiloi, T, Tiraidis, C, Zographos, S.E, Gyorgydeak, Z, Somsak, L, Docsa, T, Gergely, P, Kolisis, F.N, Oikonomakos, N.G. | Deposit date: | 2004-12-31 | Release date: | 2005-12-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-d-glucopyranosylamine and N-trifluoroacetyl-beta-d-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase Bioorg.Med.Chem., 14, 2006
|
|
1WXZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1wxz by Molmil](/molmil-images/mine/1wxz) | Crystal structure of adenosine deaminase ligated with a potent inhibitor | Descriptor: | 1-((1R,2S)-1-{2-[2-(4-CHLOROPHENYL)-1,3-BENZOXAZOL-7-YL]ETHYL}-2-HYDROXYPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | Authors: | Kinoshita, T. | Deposit date: | 2005-02-02 | Release date: | 2005-08-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism J.Med.Chem., 48, 2005
|
|
1PGQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1pgq by Molmil](/molmil-images/mine/1pgq) | CRYSTALLOGRAPHIC STUDY OF COENZYME, COENZYME ANALOGUE AND SUBSTRATE BINDING IN 6-PHOSPHOGLUCONATE DEHYDROGENASE: IMPLICATIONS FOR NADP SPECIFICITY AND THE ENZYME MECHANISM | Descriptor: | 6-PHOSPHOGLUCONATE DEHYDROGENASE, ADENOSINE-2'-MONOPHOSPHATE, SULFATE ION | Authors: | Adams, M.J, Phillips, C, Gover, S. | Deposit date: | 1994-07-18 | Release date: | 1995-02-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism. Structure, 2, 1994
|
|
3VAS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3vas by Molmil](/molmil-images/mine/3vas) | Adenosine kinase from Schistosoma mansoni in complex with adenosine in occluded loop conformation | Descriptor: | ADENOSINE, CHLORIDE ION, Putative adenosine kinase | Authors: | Romanello, L, Bachega, F.R, Garatt, R.C, DeMarco, R, Brandao-neto, J, Pereira, H.M. | Deposit date: | 2011-12-29 | Release date: | 2012-11-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Adenosine kinase from Schistosoma mansoni: structural basis for the differential incorporation of nucleoside analogues. Acta Crystallogr.,Sect.D, 69, 2013
|
|
1NUT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nut by Molmil](/molmil-images/mine/1nut) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH ATP ANALOG | Descriptor: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, FKSG76, SULFATE ION | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
|
|
1XC7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xc7 by Molmil](/molmil-images/mine/1xc7) | Binding of beta-D-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: Kinetic and crystallographic studies | Descriptor: | Glycogen phosphorylase, muscle form, N-(dimethoxyphosphoryl)-beta-D-glucopyranosylamine, ... | Authors: | Chrysina, E.D, Kosmopoulou, M.N, Kardakaris, R, Bischler, N, Leonidas, D.D, Kannan, T, Loganathan, D, Oikonomakos, N.G. | Deposit date: | 2004-09-01 | Release date: | 2005-02-08 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Binding of beta-d-glucopyranosyl bismethoxyphosphoramidate to glycogen phosphorylase b: kinetic and crystallographic studies Bioorg.Med.Chem., 13, 2005
|
|
4I93
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4i93 by Molmil](/molmil-images/mine/4i93) | Structure of the BSK8 kinase domain (SeMet labeled) | Descriptor: | Probable serine/threonine-protein kinase At5g41260 | Authors: | Gruetter, C, Rauh, D. | Deposit date: | 2012-12-04 | Release date: | 2013-08-14 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture J.Mol.Biol., 425, 2013
|
|
1NUU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nuu by Molmil](/molmil-images/mine/1nuu) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH NAD | Descriptor: | FKSG76, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
|
|
1NYQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nyq by Molmil](/molmil-images/mine/1nyq) | Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with an analogue of threonyl adenylate | Descriptor: | 5'-O-(N-(L-THREONYL)-SULFAMOYL)ADENOSINE, ZINC ION, threonyl-tRNA synthetase 1 | Authors: | Torres-Larios, A, Sankaranarayanan, R, Rees, B, Dock-Bregeon, A.C, Moras, D. | Deposit date: | 2003-02-13 | Release date: | 2003-10-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Conformational movements and cooperativity upon amino acid, ATP and tRNA binding in threonyl-tRNA synthetase J.Mol.Biol., 331, 2003
|
|
1NUQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nuq by Molmil](/molmil-images/mine/1nuq) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NMN/NaMN ADENYLYLTRANSFERASE COMPLEXED WITH NaAD | Descriptor: | FKSG76, NICOTINIC ACID ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Zhang, X, Kurnasov, O.V, Karthikeyan, S, Grishin, N.V, Osterman, A.L, Zhang, H. | Deposit date: | 2003-02-01 | Release date: | 2003-06-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | STRUCTURAL CHARACTERIZATION OF A HUMAN CYTOSOLIC NMN/NaMN
ADENYLYLTRANSFERASE AND IMPLICATION IN HUMAN NAD BIOSYNTHESIS J.Biol.Chem., 278, 2003
|
|
4I92
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4i92 by Molmil](/molmil-images/mine/4i92) | Structure of the BSK8 kinase domain | Descriptor: | CHLORIDE ION, Probable serine/threonine-protein kinase At5g41260 | Authors: | Gruetter, C, Rauh, D. | Deposit date: | 2012-12-04 | Release date: | 2013-08-14 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture J.Mol.Biol., 425, 2013
|
|
4GTY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gty by Molmil](/molmil-images/mine/4gty) | Crystal structure of mouse Enpp1 in complex with GMP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Kato, K, Nishimasu, H, Ishitani, R, Nureki, O. | Deposit date: | 2012-08-29 | Release date: | 2012-11-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling. Proc.Natl.Acad.Sci.USA, 109, 2012
|
|
1PKX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1pkx by Molmil](/molmil-images/mine/1pkx) | Crystal Structure of human ATIC in complex with XMP | Descriptor: | Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, XANTHOSINE-5'-MONOPHOSPHATE | Authors: | Wolan, D.W, Cheong, C.G, Greasley, S.E, Wilson, I.A. | Deposit date: | 2003-06-06 | Release date: | 2004-02-17 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Insights into the Human and Avian IMP Cyclohydrolase Mechanism via Crystal Structures with the Bound XMP Inhibitor. Biochemistry, 43, 2004
|
|
1U9Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1u9y by Molmil](/molmil-images/mine/1u9y) | Crystal Structure of Phosphoribosyl Diphosphate Synthase from Methanocaldococcus jannaschii | Descriptor: | Ribose-phosphate pyrophosphokinase | Authors: | Kadziola, A, Johansson, E, Jepsen, C.H, McGuire, J, Larsen, S, Hove-Jensen, B. | Deposit date: | 2004-08-11 | Release date: | 2005-08-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii J.Mol.Biol., 354, 2005
|
|
3MDD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3mdd by Molmil](/molmil-images/mine/3mdd) | |
1YUN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yun by Molmil](/molmil-images/mine/1yun) | Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Pseudomonas aeruginosa | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Probable nicotinate-nucleotide adenylyltransferase | Authors: | Yoon, H.J, Kim, H.L, Mikami, B, Suh, S.W. | Deposit date: | 2005-02-14 | Release date: | 2005-11-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Pseudomonas aeruginosa in its Apo and substrate-complexed forms reveals a fully open conformation J.Mol.Biol., 351, 2005
|
|
1YUM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yum by Molmil](/molmil-images/mine/1yum) | Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Pseudomonas aeruginosa | Descriptor: | 'Probable nicotinate-nucleotide adenylyltransferase, CITRIC ACID, NICOTINATE MONONUCLEOTIDE | Authors: | Yoon, H.J, Kim, H.L, Mikami, B, Suh, S.W. | Deposit date: | 2005-02-14 | Release date: | 2005-11-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Pseudomonas aeruginosa in its Apo and substrate-complexed forms reveals a fully open conformation J.Mol.Biol., 351, 2005
|
|
3X0N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3x0n by Molmil](/molmil-images/mine/3x0n) | ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESM-state at reaction time of 6 min | Descriptor: | ADP-ribose pyrophosphatase, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Furuike, Y, Akita, Y, Miyahara, I, Kamiya, N. | Deposit date: | 2014-10-17 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | ADP-Ribose Pyrophosphatase Reaction in Crystalline State Conducted by Consecutive Binding of Two Manganese(II) Ions as Cofactors Biochemistry, 55, 2016
|
|
1P4G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1p4g by Molmil](/molmil-images/mine/1p4g) | Crystal structure of glycogen phosphorylase b in complex with C-(1-azido-alpha-D-glucopyranosyl)formamide | Descriptor: | C-(1-AZIDO-ALPHA-D-GLUCOPYRANOSYL) FORMAMIDE, Glycogen phosphorylase, muscle form, ... | Authors: | Chrysina, E.D, Oikonomakos, N.G, Zographos, S.E, Kosmopoulou, M.N, Bischler, N, Leonidas, D.D, Nagy, V, Somsak, L, Gergely, P, Praly, J.-P. | Deposit date: | 2003-04-23 | Release date: | 2004-05-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crsytallographic Studies on alpha- and beta-D-glucopyranosyl Formamide Analogues, Inhibitors of Glycogen Phosphorylase Biocatal.Biotransfor., 21, 2003
|
|
3X0P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3x0p by Molmil](/molmil-images/mine/3x0p) | ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESMM-state at reaction time of 15 min | Descriptor: | ADP-ribose pyrophosphatase, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Furuike, Y, Akita, Y, Miyahara, I, Kamiya, N. | Deposit date: | 2014-10-17 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | ADP-Ribose Pyrophosphatase Reaction in Crystalline State Conducted by Consecutive Binding of Two Manganese(II) Ions as Cofactors Biochemistry, 55, 2016
|
|
3X0R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3x0r by Molmil](/molmil-images/mine/3x0r) | DP ribose pyrophosphatase from Thermus thermophilus HB8 in E'-state at reaction time of 30 min | Descriptor: | ADP-ribose pyrophosphatase, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Furuike, Y, Akita, Y, Miyahara, I, Kamiya, N. | Deposit date: | 2014-10-17 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | ADP-Ribose Pyrophosphatase Reaction in Crystalline State Conducted by Consecutive Binding of Two Manganese(II) Ions as Cofactors Biochemistry, 55, 2016
|
|
1YUL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yul by Molmil](/molmil-images/mine/1yul) | Crystal Structure of Nicotinic Acid Mononucleotide Adenylyltransferase from Pseudomonas aeruginosa | Descriptor: | CITRIC ACID, Probable nicotinate-nucleotide adenylyltransferase | Authors: | Yoon, H.J, Kim, H.L, Mikami, B, Suh, S.W. | Deposit date: | 2005-02-14 | Release date: | 2005-11-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Pseudomonas aeruginosa in its Apo and substrate-complexed forms reveals a fully open conformation J.Mol.Biol., 351, 2005
|
|
3X0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3x0o by Molmil](/molmil-images/mine/3x0o) | ADP ribose pyrophosphatase from Thermus thermophilus HB8 in ESMM-state at reaction time of 10 min | Descriptor: | ADP-ribose pyrophosphatase, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Furuike, Y, Akita, Y, Miyahara, I, Kamiya, N. | Deposit date: | 2014-10-17 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | ADP-Ribose Pyrophosphatase Reaction in Crystalline State Conducted by Consecutive Binding of Two Manganese(II) Ions as Cofactors Biochemistry, 55, 2016
|
|
1XJD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xjd by Molmil](/molmil-images/mine/1xjd) | |
1O5R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1o5r by Molmil](/molmil-images/mine/1o5r) | Crystal structure of adenosine deaminase complexed with a potent inhibitor | Descriptor: | 1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | Authors: | Kinoshita, T. | Deposit date: | 2003-10-05 | Release date: | 2004-09-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors J.Med.Chem., 47, 2004
|
|