PDB: 46200 resultsInfo pagesStatus searchChemie searchBIRD

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2BE5	Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with inhibitor tagetitoxin Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ... Authors: Vassylyev, D.G, Svetlov, V, Vassylyeva, M.N, Perederina, A, Igarashi, N, Matsugaki, N, Wakatsuki, S, Artsimovitch, I, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-10-22 Release date: 2005-11-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for transcription inhibition by tagetitoxin Nat.Struct.Mol.Biol., 12, 2005
5WLZ	Crystal Structure of Amino Acids 1677-1758 of Human Beta Cardiac Myosin Fused to Xrcc4 Descriptor: DNA repair protein XRCC4,Myosin-7 Authors: Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. Deposit date: 2017-07-28 Release date: 2017-08-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
8XMC	Post-translocated Pol IV transcription elongation complex Descriptor: DNA-directed RNA polymerase IV subunit 1, DNA-directed RNA polymerase IV subunit 7, DNA-directed RNA polymerases II and IV subunit 5A, ... Authors: Huang, K, Fang, C.L, Zhang, Y. Deposit date: 2023-12-27 Release date: 2024-07-24 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Transcription of the Plant RNA polymerase IV is prone to backtracking To Be Published
9COJ	SH3-like tandem domain of human KIN protein Descriptor: DNA/RNA-binding protein KIN17 Authors: de Lourenco, I.O, Fossey, M.A, Souza, F.P, Seixas, F.A.V, Fernandez, M.A, Almeida, F.C.L, Caruso, I.P. Deposit date: 2024-07-16 Release date: 2024-07-31 Method: SOLUTION NMR Cite: Solution structure of SH3-like tandem domain of human KIN protein and its interaction with RNA homo-oligonucleotides To Be Published
7OUG	STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir Descriptor: DNA (5'-D(*AP*CP*TP*GP*TP*GP*TP*TP*TP*GP*GP*CP*GP*CP*TP*TP*CP*TP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*AP*GP*AP*AP*GP*CP*GP*CP*CP*AP*AP*AP*CP*AP*CP*A)-3'), Integrase, ... Authors: Barski, M.S, Ballandras-Colas, A, Cronin, N.B, Pye, V.E, Cherepanov, P, Maertens, G.N. Deposit date: 2021-06-11 Release date: 2021-08-18 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures. Nat Commun, 12, 2021
8P0N	Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex shallow conformation Descriptor: DNA-directed RNA polymerase 133 kDa polypeptide, DNA-directed RNA polymerase 147 kDa polypeptide, DNA-directed RNA polymerase 18 kDa subunit, ... Authors: Grimm, C, Jungwirth, S, Fischer, U. Deposit date: 2023-05-10 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (2.58 Å) Cite: Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex (CASP target) To Be Published
8P0J	Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex Descriptor: DNA-directed RNA polymerase 133 kDa polypeptide, DNA-directed RNA polymerase 147 kDa polypeptide, DNA-directed RNA polymerase 18 kDa subunit, ... Authors: Grimm, C, Jungwirth, S, Fischer, U. Deposit date: 2023-05-10 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (2.39 Å) Cite: Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex (CASP target) To Be Published
4P3V	Crystal structure of the E. coli HU beta2 protein Descriptor: DNA-binding protein HU-beta, LITHIUM ION Authors: Le Meur, R, Coste, F, Castaing, B. Deposit date: 2014-03-10 Release date: 2015-04-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystal structure of the E. coli HU beta2 protein To Be Published
6EYD	Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Kouba, T, Barvik, I, Krasny, L. Deposit date: 2017-11-11 Release date: 2018-12-12 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.22 Å) Cite: The Core and Holoenzyme Forms of RNA Polymerase fromMycobacterium smegmatis. J. Bacteriol., 201, 2019
6Z11	Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State III, primary channel dis-engaged and active site interfering Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Kouba, T, Koval, T, Krasny, L, Dohnalek, J. Deposit date: 2020-05-11 Release date: 2020-11-04 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.36 Å) Cite: HelD, a helicase-like protein from gram-positive bacteria in complex with RNA polymerase To Be Published
7DY6	A refined cryo-EM structure of an Escherichia coli RNAP-promoter open complex (RPo) with SspA Descriptor: DNA (63-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Lin, W. Deposit date: 2021-01-20 Release date: 2021-11-17 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: A unique binding between SspA and RNAP beta' NTH across low-GC Gram-negative bacteria facilitates SspA-mediated transcription regulation. Biochem.Biophys.Res.Commun., 583, 2021
8U17	The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide Descriptor: DNA damage-binding protein 1, Protein cereblon, S-Pomalidomide, ... Authors: Clifton, M.C, Ma, X, Ornelas, E. Deposit date: 2023-08-30 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon. Sci Rep, 13, 2023
4EXT	Structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase zeta Descriptor: DNA repair protein REV1, Mitotic spindle assembly checkpoint protein MAD2B, peptide from DNA polymerase zeta catalytic subunit Authors: Liu, D.N, Ryu, K.S, Ko, J.S, Choi, B.S. Deposit date: 2012-05-01 Release date: 2013-05-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Insights into the scaffold mechanism of human Rev1 in translesional synthesis revealed by structural studies on its polymerase-interacting domain To be Published
9C7A	Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, SODIUM ION, ... Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2024-06-10 Release date: 2024-10-02 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published
3LU0	Molecular model of Escherichia coli core RNA polymerase Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Darst, S.A. Deposit date: 2010-02-16 Release date: 2010-09-29 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (11.2 Å) Cite: Complete structural model of Escherichia coli RNA polymerase from a hybrid approach. Plos Biol., 8, 2010
6MGN	mouse Id1 (51-104) - human hE47 (348-399) complex Descriptor: DNA-binding protein inhibitor ID-1, Transcription factor E2-alpha Authors: Benezra, R, Pavletich, N.P, Gall, A.-L, Goldgur, Y. Deposit date: 2018-09-14 Release date: 2019-09-18 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.901 Å) Cite: A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Rep, 29, 2019
3H0G	RNA Polymerase II from Schizosaccharomyces pombe Descriptor: DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Spahr, H, Calero, G, Bushnell, D.A, Kornberg, R.D. Deposit date: 2009-04-09 Release date: 2009-08-25 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.65 Å) Cite: Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution. Proc.Natl.Acad.Sci.USA, 106, 2009
7DN3	Structure of Human RNA Polymerase III elongation complex Descriptor: DNA (5'-D(P*TP*CP*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*TP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase III subunit RPC1, ... Authors: Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. Deposit date: 2020-12-08 Release date: 2021-03-17 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structure of human RNA polymerase III elongation complex. Cell Res., 31, 2021
7DU2	RNA polymerase III EC complex in post-translocation state Descriptor: DNA (5'-D(P*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*T)-3'), DNA-directed RNA polymerase III subunit RPC1, ... Authors: Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. Deposit date: 2021-01-07 Release date: 2021-03-17 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structure of human RNA polymerase III elongation complex. Cell Res., 31, 2021
8DKC	P. gingivalis RNA Polymerase Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Bu, F. Deposit date: 2022-07-05 Release date: 2023-06-21 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Cryo-EM Structure of Porphyromonas gingivalis RNA Polymerase. J.Mol.Biol., 436, 2024
7YCX	The structure of INTAC-PEC complex Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... Authors: Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. Deposit date: 2022-07-02 Release date: 2023-03-15 Last modified: 2023-09-27 Method: ELECTRON MICROSCOPY (4.18 Å) Cite: Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
3BO4	A relaxed active site following exon ligation by a group I intron Descriptor: DNA/RNA (5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*A)-D(P*DG)-3'), DNA/RNA (5'-R(*CP*A)-D(P*DU)-R(P*AP*CP*GP*GP*CP*C)-3'), Group I intron P9, ... Authors: Lipchock, S.V, Strobel, S.A. Deposit date: 2007-12-17 Release date: 2008-04-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.33 Å) Cite: A relaxed active site after exon ligation by the group I intron Proc.Natl.Acad.Sci.Usa, 105, 2008
8CEN	Yeast RNA polymerase II transcription pre-initiation complex with core Mediator Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... Authors: Wang, H, Schilbach, S, Cramer, P. Deposit date: 2023-02-02 Release date: 2023-03-22 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain. Proc.Natl.Acad.Sci.USA, 120, 2023
6ASG	Crystal structure of Thermus thermophilus RNA polymerase core enzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, Y, Lin, W, Ying, R, Ebright, R.H. Deposit date: 2017-08-24 Release date: 2018-04-11 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Mol. Cell, 70, 2018
6WJV	Structure of the Saccharomyces cerevisiae polymerase epsilon holoenzyme Descriptor: DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, DNA polymerase epsilon subunit C, ... Authors: Yuan, Z, Georgescu, R, Schauer, G.D, O'Donnell, M, Li, H. Deposit date: 2020-04-14 Release date: 2020-07-08 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structure of the polymerase epsilon holoenzyme and atomic model of the leading strand replisome. Nat Commun, 11, 2020

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