5DQK
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![BU of 5dqk by Molmil](/molmil-images/mine/5dqk) | Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mg2+ | Descriptor: | MAGNESIUM ION, POTASSIUM ION, RNA (48-MER), ... | Authors: | Mir, A, Chen, J, Neau, D, Golden, B.L. | Deposit date: | 2015-09-14 | Release date: | 2015-10-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.707 Å) | Cite: | Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction. Biochemistry, 54, 2015
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5IPF
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![BU of 5ipf by Molmil](/molmil-images/mine/5ipf) | Crystal structure of Hypoxanthine-guanine phosphoribosyltransferase from Schistosoma mansoni in complex with IMP | Descriptor: | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT), INOSINIC ACID | Authors: | Romanello, L, Torini, J.R.S, Bird, L.E, Nettleship, J.E, Owens, R.J, DeMarco, R, Pereira, H.M, Brandao-Neto, J. | Deposit date: | 2016-03-09 | Release date: | 2017-03-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases. Mol. Biochem. Parasitol., 229, 2019
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3I8W
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![BU of 3i8w by Molmil](/molmil-images/mine/3i8w) | |
6YJ6
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![BU of 6yj6 by Molmil](/molmil-images/mine/6yj6) | Structure of the TFIIIC subcomplex tauA | Descriptor: | Transcription factor tau 131 kDa subunit, Transcription factor tau 55 kDa subunit, Transcription factor tau 95 kDa subunit,Transcription factor tau 95 kDa subunit | Authors: | Vorlaender, M.K, Muller, C.W. | Deposit date: | 2020-04-02 | Release date: | 2020-09-16 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the TFIIIC subcomplex tau A provides insights into RNA polymerase III pre-initiation complex formation. Nat Commun, 11, 2020
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1P8K
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![BU of 1p8k by Molmil](/molmil-images/mine/1p8k) | |
2IJK
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![BU of 2ijk by Molmil](/molmil-images/mine/2ijk) | Structure of a Rom protein dimer at 1.55 angstrom resolution | Descriptor: | Regulatory protein rop | Authors: | Struble, E.B. | Deposit date: | 2006-09-29 | Release date: | 2007-10-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | New crystal structures of ColE1 Rom and variants resulting from mutation of a surface exposed residue: Implications for RNA-recognition. Proteins, 72, 2008
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2IJI
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![BU of 2iji by Molmil](/molmil-images/mine/2iji) | Structure of F14H mutant of ColE1 Rom protein | Descriptor: | Regulatory protein rop | Authors: | Struble, E.B. | Deposit date: | 2006-09-29 | Release date: | 2007-10-16 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | New crystal structures of ColE1 Rom and variants resulting from mutation of a surface exposed residue: Implications for RNA-recognition. Proteins, 72, 2008
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3OYP
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![BU of 3oyp by Molmil](/molmil-images/mine/3oyp) | HCV NS3/4A in complex with ligand 3 | Descriptor: | Non-structural protein 4A, Peptidomimetic inhibitor, Serine protease NS3, ... | Authors: | Hagel, M, Niu, D, St.Martin, T, Sheets, M.P, Qiao, L, Bernard, H, Karp, R.M, Zhu, Z, Labenski, M.T, Chaturvedi, P.C, Nacht, M, Westlin, W.F, Petter, R.C, Singh, J. | Deposit date: | 2010-09-23 | Release date: | 2010-12-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine. Nat.Chem.Biol., 7, 2011
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2W4B
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![BU of 2w4b by Molmil](/molmil-images/mine/2w4b) | Epstein-Barr virus alkaline nuclease D203S mutant | Descriptor: | ALKALINE EXONUCLEASE | Authors: | Buisson, M, Geoui, T, Flot, D, Tarbouriech, N, Burmeister, W.P. | Deposit date: | 2008-11-24 | Release date: | 2009-06-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | A Bridge Crosses the Active Site Canyon of the Epstein-Barr Virus Nuclease with DNase and Rnase Activity. J.Mol.Biol., 391, 2009
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1ROQ
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7XRW
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![BU of 7xrw by Molmil](/molmil-images/mine/7xrw) | Solution structure of T. brucei RAP1 | Descriptor: | Repressor activator protein 1 | Authors: | Yang, X, Pan, X.H, Ji, Z.Y, Wong, K.B, Zhang, M.J, Zhao, Y.X. | Deposit date: | 2022-05-12 | Release date: | 2023-03-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The RRM-mediated RNA binding activity in T. brucei RAP1 is essential for VSG monoallelic expression. Nat Commun, 14, 2023
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1R4K
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![BU of 1r4k by Molmil](/molmil-images/mine/1r4k) | Solution Structure of the Drosophila Argonaute 1 PAZ Domain | Descriptor: | Argonaute 1 | Authors: | Yan, K.S, Yan, S, Farooq, A, Han, A, Zeng, L, Zhou, M.-M. | Deposit date: | 2003-10-07 | Release date: | 2003-12-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and conserved RNA binding of the PAZ domain Nature, 426, 2003
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5K1S
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![BU of 5k1s by Molmil](/molmil-images/mine/5k1s) | crystal structure of AibC | Descriptor: | Oxidoreductase, zinc-binding dehydrogenase family, ZINC ION | Authors: | Bock, T, Mueller, R, Blankenfeldt, W. | Deposit date: | 2016-05-18 | Release date: | 2016-08-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus. Acta Crystallogr.,Sect.F, 72, 2016
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7X73
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![BU of 7x73 by Molmil](/molmil-images/mine/7x73) | Structure of G9a in complex with RK-701 | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase EHMT2, ... | Authors: | Niwa, H, Shirai, F, Sato, S, Nishigaya, Y, Shirouzu, M, Umehara, T. | Deposit date: | 2022-03-09 | Release date: | 2022-12-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nat Commun, 14, 2023
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3TY9
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![BU of 3ty9 by Molmil](/molmil-images/mine/3ty9) | Crystal Structure of C. Thermocellum PNKP Ligase Domain AMP-Adenylate | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE MONOPHOSPHATE, ... | Authors: | Smith, P, Wang, L, Shuman, S. | Deposit date: | 2011-09-24 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family. Proc.Natl.Acad.Sci.USA, 109, 2012
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2W45
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![BU of 2w45 by Molmil](/molmil-images/mine/2w45) | Epstein-Barr virus alkaline nuclease | Descriptor: | ALKALINE EXONUCLEASE | Authors: | Buisson, M, Geoui, T, Flot, D, Tarbouriech, N, Burmeister, W.P. | Deposit date: | 2008-11-21 | Release date: | 2009-06-30 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | A Bridge Crosses the Active Site Canyon of the Epstein-Barr Virus Nuclease with DNase and Rnase Activity. J.Mol.Biol., 391, 2009
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3TY8
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![BU of 3ty8 by Molmil](/molmil-images/mine/3ty8) | Crystal Structure of C. Thermocellum PNKP Ligase Domain Apo Form | Descriptor: | D(-)-TARTARIC ACID, GLYCEROL, Polynucleotide 2',3'-cyclic phosphate phosphodiesterase / polynucleotide 5'-hydroxyl-kinase / polynucleotide 3'-phosphatase | Authors: | Smith, P, Wang, L, Shuman, S. | Deposit date: | 2011-09-23 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family. Proc.Natl.Acad.Sci.USA, 109, 2012
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2FM2
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![BU of 2fm2 by Molmil](/molmil-images/mine/2fm2) | HCV NS3-4A protease domain complexed with a ketoamide inhibitor, SCH446211 | Descriptor: | BETA-MERCAPTOETHANOL, NS3 protease/helicase, NS4a protein, ... | Authors: | Yi, M, Tong, X, Skelton, A, Chase, R, Chen, T, Prongay, A, Bogen, S.L, Saksena, A.K, Njoroge, F.G, Veselenak, R.L, Pyles, R.B, Bourne, N, Malcolm, B.A, Lemon, S.M. | Deposit date: | 2006-01-06 | Release date: | 2006-02-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations J.Biol.Chem., 281, 2006
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2XXA
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![BU of 2xxa by Molmil](/molmil-images/mine/2xxa) | The Crystal Structure of the Signal Recognition Particle (SRP) in Complex with its Receptor(SR) | Descriptor: | 4.5S RNA, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Ataide, S.F, Schmitz, N, Shen, K, Ke, A, Shan, S, Doudna, J.A, Ban, N. | Deposit date: | 2010-11-09 | Release date: | 2011-03-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.94 Å) | Cite: | The Crystal Structure of the Signal Recognition Particle in Complex with its Receptor. Science, 331, 2011
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3TY5
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![BU of 3ty5 by Molmil](/molmil-images/mine/3ty5) | Crystal Structure of C. thermocellum PNKP Ligase domain in complex with ATP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Polynucleotide 2',3'-cyclic phosphate phosphodiesterase / polynucleotide 5'-hydroxyl-kinase / polynucleotide 3'-phosphatase, ... | Authors: | Smith, P, Wang, L, Shuman, S. | Deposit date: | 2011-09-23 | Release date: | 2012-01-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family. Proc.Natl.Acad.Sci.USA, 109, 2012
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2B3X
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![BU of 2b3x by Molmil](/molmil-images/mine/2b3x) | Structure of an orthorhombic crystal form of human cytosolic aconitase (IRP1) | Descriptor: | 1,2-ETHANEDIOL, IRON/SULFUR CLUSTER, Iron-responsive element binding protein 1, ... | Authors: | Dupuy, J, Fontecilla-Camps, J.C, Volbeda, A. | Deposit date: | 2005-09-22 | Release date: | 2006-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Crystal structure of human iron regulatory protein 1 as cytosolic aconitase Structure, 14, 2006
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1MBM
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![BU of 1mbm by Molmil](/molmil-images/mine/1mbm) | NSP4 proteinase from Equine Arteritis Virus | Descriptor: | chymotrypsin-like serine protease | Authors: | Barrette-Ng, I.H, Ng, K.K.-S, Mark, B.L, van Aken, D, Cherney, M.M, Garen, C, Kolodenko, Y, Gorbalenya, A.E, Snijder, E.J, James, M.N.G. | Deposit date: | 2002-08-03 | Release date: | 2002-10-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Arterivirus nsp4: the smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole J.Biol.Chem., 277, 2002
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2LTS
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![BU of 2lts by Molmil](/molmil-images/mine/2lts) | Solution structure of RDE-4(150-235) | Descriptor: | Protein RDE-4 | Authors: | Deshmukh, M, Chiliveri, S. | Deposit date: | 2012-05-31 | Release date: | 2013-12-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of RDE-4 dsRBDs and mutational studies provide insights into dsRNA recognition in the Caenorhabditis elegans RNAi pathway. Biochem.J., 458, 2014
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2LTR
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![BU of 2ltr by Molmil](/molmil-images/mine/2ltr) | Solution structure of RDE-4(32-136) | Descriptor: | Protein RDE-4 | Authors: | Deshmukh, M, Chiliveri, S. | Deposit date: | 2012-05-31 | Release date: | 2013-12-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of RDE-4 dsRBDs and mutational studies provide insights into dsRNA recognition in the Caenorhabditis elegans RNAi pathway. Biochem.J., 458, 2014
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8XT2
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![BU of 8xt2 by Molmil](/molmil-images/mine/8xt2) | Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline | Descriptor: | 12s rRNA, 16s rRNA, 39S ribosomal protein L22, ... | Authors: | Li, X, Wang, M, Cheng, J. | Deposit date: | 2024-01-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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