7X73

Structure of G9a in complex with RK-701

Summary for 7X73

• Entry DOI: 10.2210/pdb7x73/pdb
• Descriptor: Histone-lysine N-methyltransferase EHMT2, ZINC ION, SINEFUNGIN, ... (7 entities in total)
• Functional Keywords: histone lysine methyltransferase, inhibitor, protein-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 67697.32

Authors

Niwa, H.,Shirai, F.,Sato, S.,Nishigaya, Y.,Shirouzu, M.,Umehara, T. (deposition date: 2022-03-09, release date: 2022-12-21, Last modification date: 2023-11-29)

• Primary citation: Takase, S.,Hiroyama, T.,Shirai, F.,Maemoto, Y.,Nakata, A.,Arata, M.,Matsuoka, S.,Sonoda, T.,Niwa, H.,Sato, S.,Umehara, T.,Shirouzu, M.,Nishigaya, Y.,Sumiya, T.,Hashimoto, N.,Namie, R.,Usui, M.,Ohishi, T.,Ohba, S.I.,Kawada, M.,Hayashi, Y.,Harada, H.,Yamaguchi, T.,Shinkai, Y.,Nakamura, Y.,Yoshida, M.,Ito, A.; A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression.; Nat Commun, 14:23-23, 2023; PubMed: 36635268; DOI: 10.1038/s41467-022-35404-0

Experimental method

X-RAY DIFFRACTION (1.49 Å)