Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6H5O
DownloadVisualize
BU of 6h5o by Molmil
Crystal structure of PBP2a from MRSA in complex with piperacillin at active site.
Descriptor: CADMIUM ION, Penicillin binding protein 2 prime, Piperacillin (Open Form)
Authors:Batuecas, M.T, Martinez-Caballero, S, Hermoso, J.A.
Deposit date:2018-07-25
Release date:2019-08-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus.
Antimicrob.Agents Chemother., 63, 2019
6G9P
DownloadVisualize
BU of 6g9p by Molmil
Structural basis for the inhibition of E. coli PBP2
Descriptor: Peptidoglycan D,D-transpeptidase MrdA
Authors:Ruff, M, Levy, N.
Deposit date:2018-04-11
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
J.Med.Chem., 62, 2019
6HR6
DownloadVisualize
BU of 6hr6 by Molmil
Nitrocefin reacted with catalytic serine (Ser294) of penicillin-binding protein 3 from Pseudomonas aeruginosa
Descriptor: Nitrocefin - open form, Peptidoglycan D,D-transpeptidase FtsI
Authors:Bellini, D, Dowson, C.G.
Deposit date:2018-09-26
Release date:2019-10-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Nitrocefin acylation of single catalytic serine of penicillin-binding protein 3 from P. aeruginosa
To Be Published
6HR4
DownloadVisualize
BU of 6hr4 by Molmil
Apo form of penicillin-binding protein 3 from P. aeruginosa
Descriptor: Peptidoglycan D,D-transpeptidase FtsI
Authors:Bellini, D, Dowson, C.G.
Deposit date:2018-09-26
Release date:2019-10-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Apo form of penicillin-binding protein 3 from P. aeruginosa
To Be Published
6G0K
DownloadVisualize
BU of 6g0k by Molmil
Crystal structure of Enterococcus faecium D63r Penicillin-Binding protein 5 (PBP5fm)
Descriptor: Low affinity penicillin-binding protein 5 (PBP5), SULFATE ION
Authors:Sauvage, E, El Gachi, M, Herman, R, Kerff, F, Charlier, P.
Deposit date:2018-03-19
Release date:2019-04-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of inactivation of Enterococcus faecium penicillin binding protein 5 by ceftobiprole.
To Be Published
6G9F
DownloadVisualize
BU of 6g9f by Molmil
Structural basis for the inhibition of E. coli PBP2
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Peptidoglycan D,D-transpeptidase MrdA
Authors:Ruff, M, Levy, N.
Deposit date:2018-04-10
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
J.Med.Chem., 62, 2019
6I1E
DownloadVisualize
BU of 6i1e by Molmil
Crystal structure of Pseudomonas aeruginosa Penicillin-Binding Protein 3 in complex with amoxicillin
Descriptor: 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Peptidoglycan D,D-transpeptidase FtsI
Authors:Bellini, D, Dowson, C.G.
Deposit date:2018-10-28
Release date:2019-11-20
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of beta-Lactam Target-Mediated Resistance.
J.Mol.Biol., 431, 2019
7BN9
DownloadVisualize
BU of 7bn9 by Molmil
Crystal Structure of Bacillus subtilis Penicillin Binding Protein 3
Descriptor: Penicillin-binding protein 3
Authors:Rao, V.A, Lewis, R.J.
Deposit date:2021-01-21
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Cooperation between peptidoglycan transpeptidases and SEDS proteins in Bacillus subtilis cell division
To Be Published
7ATM
DownloadVisualize
BU of 7atm by Molmil
Structure of P. aeruginosa PBP3 in complex with a phenyl boronic acid (Compound 1)
Descriptor: (3-(1H-tetrazol-5-yl)phenyl)boronic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-10-30
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.582 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7ATO
DownloadVisualize
BU of 7ato by Molmil
Structure of P. aeruginosa PBP3 in complex with an aryl boronic acid (Compound 2)
Descriptor: (5-methyl-1H-indazol-6-yl)boronic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-10-30
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.587 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7AU0
DownloadVisualize
BU of 7au0 by Molmil
Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 7)
Descriptor: Peptidoglycan D,D-transpeptidase FtsI, methyl (R)-2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxamido)-2-phenylacetate
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-02
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7ATX
DownloadVisualize
BU of 7atx by Molmil
Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 4)
Descriptor: 4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonyl)-1,3,3-trimethylpiperazin-2-one, Peptidoglycan D,D-transpeptidase FtsI
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-01
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7AU8
DownloadVisualize
BU of 7au8 by Molmil
Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 13)
Descriptor: 2-(1-hydroxy-6-((2-(4-methyl-3-oxopiperazin-1-yl)-2-oxoethyl)carbamoyl)-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetic acid, Peptidoglycan D,D-transpeptidase FtsI
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-02
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7AU9
DownloadVisualize
BU of 7au9 by Molmil
Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 14)
Descriptor: GLYCEROL, N,N-dibenzyl-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborole-6-carboxamide, Peptidoglycan D,D-transpeptidase FtsI
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-02
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.137 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7ATW
DownloadVisualize
BU of 7atw by Molmil
Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 3)
Descriptor: 1-Hydroxy-1,3-dihydro-2,1-benzoxaborole-6-carboxylic acid, GLYCEROL, Peptidoglycan D,D-transpeptidase FtsI
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-01
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7AUB
DownloadVisualize
BU of 7aub by Molmil
Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 15)
Descriptor: 2-(5-(benzyloxy)-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetic acid, Peptidoglycan D,D-transpeptidase FtsI
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-02
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.907 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7AUH
DownloadVisualize
BU of 7auh by Molmil
Structure of P. aeruginosa PBP3 in complex with vaborbactam
Descriptor: GLYCEROL, Peptidoglycan D,D-transpeptidase FtsI, Vaborbactam
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-03
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.012 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
7AU1
DownloadVisualize
BU of 7au1 by Molmil
Structure of P. aeruginosa PBP3 in complex with a benzoxaborole (Compound 12)
Descriptor: 2-(6-(((R)-2-amino-2-oxo-1-phenylethyl)carbamoyl)-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acetic acid, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Newman, H, Bellini, B, Dowson, C.G.
Deposit date:2020-11-02
Release date:2021-08-11
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
J.Med.Chem., 64, 2021
6KGU
DownloadVisualize
BU of 6kgu by Molmil
Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with aztreonam
Descriptor: 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, COBALT (II) ION, Penicillin-binding protein PbpB
Authors:Lu, Z.K, Zhang, A.L, Liu, X, Guddat, L, Yang, H.T, Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.106 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGV
DownloadVisualize
BU of 6kgv by Molmil
Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with amoxicillin
Descriptor: 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, COBALT (II) ION, Penicillin-binding protein PbpB
Authors:Lu, Z.K, Zhang, A.L, Liu, X, Guddat, L, Yang, H.T, Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGH
DownloadVisualize
BU of 6kgh by Molmil
Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis (apo-form)
Descriptor: COBALT (II) ION, Penicillin-binding protein PbpB, SODIUM ION
Authors:Lu, Z.K, Zhang, A.L, Liu, X, Guddat, L, Yang, H.T, Rao, Z.H.
Deposit date:2019-07-11
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.108 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGS
DownloadVisualize
BU of 6kgs by Molmil
Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with meropenem
Descriptor: (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, COBALT (II) ION, Penicillin-binding protein PbpB
Authors:Lu, Z.K, Zhang, A.L, Liu, X, Guddat, L, Yang, H.T, Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.309 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6KGW
DownloadVisualize
BU of 6kgw by Molmil
Crystal structure of Penicillin binding protein 3 (PBP3) from Mycobacterium tuerculosis, complexed with ampicillin
Descriptor: (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, COBALT (II) ION, Penicillin-binding protein PbpB
Authors:Lu, Z.K, Zhang, A.L, Liu, X, Guddat, L, Yang, H.T, Rao, Z.H.
Deposit date:2019-07-12
Release date:2020-03-11
Method:X-RAY DIFFRACTION (2.407 Å)
Cite:Structures ofMycobacterium tuberculosisPenicillin-Binding Protein 3 in Complex with Fivebeta-Lactam Antibiotics Reveal Mechanism of Inactivation.
Mol.Pharmacol., 97, 2020
6MKF
DownloadVisualize
BU of 6mkf by Molmil
Crystal structure of penicillin binding protein 5 (PBP5) from Enterococcus faecium in the imipenem-bound form
Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, SULFATE ION, penicillin binding protein 5 (PBP5)
Authors:Moon, T.M, Lee, C, D'Andrea, E.D, Peti, W, Page, R.
Deposit date:2018-09-25
Release date:2018-10-31
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance.
J. Biol. Chem., 293, 2018
6MKH
DownloadVisualize
BU of 6mkh by Molmil
Crystal structure of pencillin binding protein 4 (PBP4) from Enterococcus faecalis in the imipenem-bound form
Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, PHOSPHATE ION, pencillin binding protein 4 (PBP4)
Authors:D'Andrea, E.D, Moon, T.M, Peti, W, Page, R.
Deposit date:2018-09-25
Release date:2018-10-31
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:The structures of penicillin-binding protein 4 (PBP4) and PBP5 fromEnterococciprovide structural insights into beta-lactam resistance.
J. Biol. Chem., 293, 2018

221371

건을2024-06-19부터공개중

PDB statisticsPDBj update infoContact PDBjnumon