PDB: 26618 resultsInfo pagesStatus searchChemie searchBIRD

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6PAO	Structure of a bacterial Atm1-family ABC exporter with ATP bound Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATM1-type heavy metal exporter Authors: Fan, C, Kaiser, J.T, Rees, D.C. Deposit date: 2019-06-11 Release date: 2020-06-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.65 Å) Cite: A structural framework for unidirectional transport by a bacterial ABC exporter. Proc.Natl.Acad.Sci.USA, 117, 2020
5YLU	Crystal structure of the gastric proton pump complexed with vonoprazan Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Abe, K, Irie, K, Nakanishi, H, Fujiyoshi, Y. Deposit date: 2017-10-19 Release date: 2018-04-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.79988956 Å) Cite: Crystal structures of the gastric proton pump Nature, 556, 2018
6PCM	Crystal Structure of Mycobacterium smegmatis Topoisomerase I with ssDNA bound to both N- and C-terminal domains Descriptor: DNA (5'-D(P*AP*GP*TP*GP*AP*GP*CP*GP*AP*GP*CP*TP*TP*CP*CP*GP*CP*TP*TP*GP*AP*CP*TP*T)-3'), DNA topoisomerase 1, SULFATE ION Authors: Tan, K, Cao, N, Tse-Dinh, Y.C. Deposit date: 2019-06-17 Release date: 2020-03-25 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.107 Å) Cite: Mechanistic insights from structure of Mycobacterium smegmatis topoisomerase I with ssDNA bound to both N- and C-terminal domains. Nucleic Acids Res., 48, 2020
6PD8	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 39 Descriptor: 5-ethoxy-2-fluoro-3-methyl-N'-(phenylsulfonyl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... Authors: Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. Deposit date: 2019-06-18 Release date: 2020-04-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.738 Å) Cite: Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDC	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 42 Descriptor: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(prop-2-en-1-yl)oxy]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... Authors: Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. Deposit date: 2019-06-18 Release date: 2020-04-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PLE	Crystal structure of MhuD R26S mutant in complex with biliverdin Descriptor: BILIVERDINE IX ALPHA, Heme oxygenase (mycobilin-producing) Authors: Chao, A, Goulding, C.W. Deposit date: 2019-06-30 Release date: 2019-11-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of aMycobacterium tuberculosisHeme-Degrading Protein, MhuD, Variant in Complex with Its Product. Biochemistry, 58, 2019
5YDY	NMR structure of YAP1-2 WW2 domain with LATS1 PPxY motif complex Descriptor: WW2 domain and PPxY motif complex Authors: Fan, J.S, Sivaraman, J. Deposit date: 2017-09-15 Release date: 2018-05-02 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Biophysical studies and NMR structure of YAP2 WW domain - LATS1 PPxY motif complexes reveal the basis of their interaction. Oncotarget, 9, 2018
6PMX	Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(3-(2-Aminoethyl)phenyl)-4-methylquinolin-2-amine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-[3-(aminomethyl)phenyl]-4-methylquinolin-2-amine, ACETATE ION, ... Authors: Li, H, Poulos, T.L. Deposit date: 2019-07-02 Release date: 2020-04-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.05 Å) Cite: First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63, 2020
6PN7	Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(3-(Aminomethyl)-4-(thiazol-4-ylmethoxy)phenyl)-4-methylquinolin-2-amine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 7-{3-(aminomethyl)-4-[(1,3-thiazol-4-yl)methoxy]phenyl}-4-methylquinolin-2-amine, ACETATE ION, ... Authors: Li, H, Poulos, T.L. Deposit date: 2019-07-02 Release date: 2020-04-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.878 Å) Cite: First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63, 2020
5G0A	The crystal structure of a S-selective transaminase from Bacillus megaterium Descriptor: DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, PYRIDOXAL-5'-PHOSPHATE, ... Authors: van Oosterwijk, N, Willies, S, Hekelaar, J, Terwisscha van Scheltinga, A.C, Turner, N.J, Dijkstra, B.W. Deposit date: 2016-03-17 Release date: 2016-07-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Basis of Substrate Range and Enantioselectivity of Two S-Selective Omega- Transaminases Biochemistry, 55, 2016
5YQZ	Structure of the glucagon receptor in complex with a glucagon analogue Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glucagon analogue, ... Authors: Zhang, H, Qiao, A, Yang, L, VAN EPS, N, Frederiksen, K, Yang, D, Dai, A, Cai, X, Zhang, H, Yi, C, Can, C, He, L, Yang, H, Lau, J, Ernst, O, Hanson, M, Stevens, R, Wang, M, Seedtz-Runge, S, Jiang, H, Zhao, Q, Wu, B. Deposit date: 2017-11-08 Release date: 2018-01-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of the glucagon receptor in complex with a glucagon analogue. Nature, 553, 2018
5FNE	CRYSTAL STRUCTURE OF FUNGAL VERSATILE PEROXIDASE FROM PLEUROTUS ERYNGII TRIPLE MUTANT E37K, H39R & G330R Descriptor: CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ... Authors: Medrano, F.J, Romero, A. Deposit date: 2015-11-13 Release date: 2016-07-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.499 Å) Cite: Unveiling the Basis of Alkaline Stability of an Evolved Versatile Peroxidase. Biochem.J., 473, 2016
6POZ	Structure of human endothelial nitric oxide synthase heme domain in complex with 7-(3-(Aminomethyl)-4-isopropoxyphenyl)-4-methylquinolin-2-amine Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, 7-{3-(aminomethyl)-4-[(propan-2-yl)oxy]phenyl}-4-methylquinolin-2-amine, ... Authors: Chreifi, G, Li, H, Poulos, T.L. Deposit date: 2019-07-05 Release date: 2020-04-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.2 Å) Cite: First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate. J.Med.Chem., 63, 2020
8CTK	Cryo-EM structure of SARS-CoV-2 M protein in a lipid nanodisc Descriptor: Membrane protein Authors: Dolan, K.A, Brohawn, S.G. Deposit date: 2022-05-15 Release date: 2022-06-22 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structure of SARS-CoV-2 M protein in lipid nanodiscs. Elife, 11, 2022
5FVO	Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(2-(5-(3-methoxypropylamino)pyridin-3-yl)ethyl)-4- methylpyridin-2-amine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-(2-(5-(3-methoxypropylamino)pyridin-3-yl)ethyl)-4-methylpyridin-2-amine, NITRIC OXIDE SYNTHASE, ... Authors: Li, H, Poulos, T.L. Deposit date: 2016-02-10 Release date: 2016-04-20 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker. J.Med.Chem., 59, 2016
6P93	Human APE1 K98A AP-endonuclease product complex Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Whitaker, A.W, Stark, W.J, Freudenthal, B.D. Deposit date: 2019-06-09 Release date: 2020-01-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance. Mutagenesis, 35, 2020
5YO5	Crystal Structure of B562RIL with engineered disulfide bond A20C-Q25C Descriptor: Soluble cytochrome b562 Authors: Pu, M, Xu, Z, Song, G, Liu, Z.J. Deposit date: 2017-10-26 Release date: 2018-03-14 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Protein crystal quality oriented disulfide bond engineering. Protein Cell, 9, 2018
8D14	Helical ADP-Pi-F-actin Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Reynolds, M.J, Alushin, G.M. Deposit date: 2022-05-26 Release date: 2022-09-07 Last modified: 2022-11-23 Method: ELECTRON MICROSCOPY (2.51 Å) Cite: Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
6PAR	Structure of a bacterial Atm1-family ABC exporter with MgAMPPNP bound Descriptor: ATM1-type heavy metal exporter, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Fan, C, Kaiser, J.T, Rees, D.C. Deposit date: 2019-06-11 Release date: 2020-06-24 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.35 Å) Cite: A structural framework for unidirectional transport by a bacterial ABC exporter. Proc.Natl.Acad.Sci.USA, 117, 2020
6PAU	Structure of Human NMT2 with myristoyl-lysine peptide and CoA products Descriptor: 4'-diphospho pantetheine, Arf6 peptide, GLYCEROL, ... Authors: Price, I.R, Lin, H. Deposit date: 2019-06-11 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.93 Å) Cite: NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun, 11, 2020
8D18	Straight ADP-F-actin 2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Reynolds, M.J, Alushin, G.M. Deposit date: 2022-05-26 Release date: 2022-09-07 Last modified: 2022-11-23 Method: ELECTRON MICROSCOPY (3.66 Å) Cite: Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
5YK7	Crystal Structure of Mdm12-Mmm1 complex Descriptor: Maintenance of mitochondrial morphology protein 1, Mitochondrial distribution and morphology protein 12, PHOSPHATE ION Authors: Jeong, H, Park, J, Lee, C. Deposit date: 2017-10-12 Release date: 2018-01-10 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.799 Å) Cite: Crystal structures of Mmm1 and Mdm12-Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8D15	Bent ADP-F-actin Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Reynolds, M.J, Alushin, G.M. Deposit date: 2022-05-26 Release date: 2022-09-07 Last modified: 2022-11-23 Method: ELECTRON MICROSCOPY (3.61 Å) Cite: Bending forces and nucleotide state jointly regulate F-actin structure. Nature, 611, 2022
6PDB	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 80 Descriptor: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyrimidin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... Authors: Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. Deposit date: 2019-06-18 Release date: 2020-04-01 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
8CYA	SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-67 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Huang, W, Taylor, D. Deposit date: 2022-05-23 Release date: 2022-07-06 Last modified: 2022-07-13 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Superimmunity by pan-sarbecovirus nanobodies. Cell Rep, 39, 2022

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