5V5P
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6P6A
| Structure of Mouse Importin alpha - NIT2 NLS peptide complex | Descriptor: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | Authors: | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | Deposit date: | 2019-06-03 | Release date: | 2020-01-29 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha. Sci Rep, 10, 2020
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6WBA
| Structure of Mouse Importin alpha MLH1- R470A NLS Peptide Complex | Descriptor: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | Authors: | de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | Deposit date: | 2020-03-26 | Release date: | 2021-07-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha. Biochem.J., 478, 2021
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3KND
| TPX2:importin-alpha complex | Descriptor: | Importin subunit alpha-2, SULFATE ION, Targeting protein for Xklp2 | Authors: | Stewart, M. | Deposit date: | 2009-11-12 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.151 Å) | Cite: | Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha. J.Biol.Chem., 285, 2010
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5U5P
| Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | Authors: | Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. | Deposit date: | 2016-12-07 | Release date: | 2018-03-14 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.171 Å) | Cite: | DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway. Biochimie, 146, 2018
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5W4E
| Importin binding to Tdt NLS peptide | Descriptor: | GLYCEROL, Importin subunit alpha-1,Importin subunit alpha-1, human DNA repair polymerase Tdt | Authors: | Pedersen, L.C, London, R. | Deposit date: | 2017-06-10 | Release date: | 2018-06-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Variations in nuclear localization strategies among pol X family enzymes. Traffic, 2018
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6D7M
| Crystal structure of the W184R/W231R Importin alpha mutant | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Peroxidase,Importin subunit alpha-1, ... | Authors: | Pedersen, L.C, London, R.E, Gabel, S.A. | Deposit date: | 2018-04-25 | Release date: | 2019-03-06 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.187 Å) | Cite: | Variations in nuclear localization strategies among pol X family enzymes. Traffic, 2018
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3UKX
| Mouse importin alpha: Bimax2 peptide complex | Descriptor: | Bimax2 peptide, Importin subunit alpha-2 | Authors: | Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. | Deposit date: | 2011-11-10 | Release date: | 2012-10-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha Traffic, 13, 2012
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1QZ7
| Beta-catenin binding domain of Axin in complex with beta-catenin | Descriptor: | Axin, Beta-catenin | Authors: | Xing, Y, Clements, W.K, Kimelman, D, Xu, W. | Deposit date: | 2003-09-15 | Release date: | 2003-11-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a beta-catenin/Axin complex suggests a mechanism for the {beta}-catenin destruction complex GENES DEV., 17, 2003
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2JDQ
| C-terminal domain of influenza A virus polymerase PB2 subunit in complex with human importin alpha5 | Descriptor: | IMPORTIN ALPHA-1 SUBUNIT, POLYMERASE BASIC PROTEIN 2 | Authors: | Tarendeau, F, Guilligay, D, Mas, P, Boulo, S, Baudin, F, Ruigrok, R.W.H, Hart, D.J, Cusack, S. | Deposit date: | 2007-01-11 | Release date: | 2007-02-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit Nat.Struct.Mol.Biol., 14, 2007
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2C1M
| Nup50:importin-alpha complex | Descriptor: | IMPORTIN-ALPHA2 SUBUNIT, NUCLEOPORIN 50 KDA | Authors: | Matsuura, Y, Stewart, M. | Deposit date: | 2005-09-16 | Release date: | 2005-11-23 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Nup50/Npap60 Function in Nuclear Protein Import Complex Disassembly and Importin Recycling. Embo J., 24, 2005
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8SV0
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7JVO
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7N9H
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5HHG
| Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex | Descriptor: | Importin subunit alpha-1, RNA-directed RNA polymerase NS5 | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-01-11 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production. PLoS Pathog., 12, 2016
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1BK5
| KARYOPHERIN ALPHA FROM SACCHAROMYCES CEREVISIAE | Descriptor: | COBALT (II) ION, KARYOPHERIN ALPHA | Authors: | Conti, E, Uy, M, Leighton, L, Blobel, G, Kuriyan, J. | Deposit date: | 1998-07-14 | Release date: | 1999-01-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell(Cambridge,Mass.), 94, 1998
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3FEY
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6BW1
| Hendra virus W protein C-terminus in complex with Importin alpha 1 | Descriptor: | Importin subunit alpha-1, Protein W | Authors: | Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-14 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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5KLR
| Prototypical P4[R]cNLS | Descriptor: | Importin subunit alpha-1, Prototypical P4[R]cNLS | Authors: | Smith, K.M, Forwood, J.K. | Deposit date: | 2016-06-25 | Release date: | 2016-07-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting. Biochim Biophys Acta Mol Cell Res, 1865, 2018
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2Z6H
| Crystal Structure of Beta-Catenin Armadillo Repeat Region and Its C-Terminal domain | Descriptor: | Catenin beta-1 | Authors: | Xing, Y, Takemaru, K, Liu, J, Zheng, J, Moon, R, Xu, W. | Deposit date: | 2007-08-01 | Release date: | 2008-02-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of a Full-Length beta-Catenin Structure, 16, 2008
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6BWA
| Hendra virus W protein C-terminus in complex with Importin alpha 3 crystal form 2 | Descriptor: | Importin subunit alpha-3, Protein W | Authors: | Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | Deposit date: | 2017-12-14 | Release date: | 2018-07-04 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses. Nat Commun, 9, 2018
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5WUN
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5H2X
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5W41
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1Y2A
| Structure of mammalian importin bound to the non-classical PLSCR1-NLS | Descriptor: | Importin alpha-2 Subunit, decamer fragment of Phospholipid scramblase 1 | Authors: | Chen, M.-H, Ben-Efraim, I, Mitrousis, G, Walker-Kopp, N, Sims, P.J, Cingolani, G. | Deposit date: | 2004-11-22 | Release date: | 2005-02-01 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Phospholipid Scramblase 1 Contains a Nonclassical Nuclear Localization Signal with Unique Binding Site in Importin alpha J.Biol.Chem., 280, 2005
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