4ODO
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![BU of 4odo by Molmil](/molmil-images/mine/4odo) | Structure of SlyD from Thermus thermophilus in complex with FK506 | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CHLORIDE ION, ... | Authors: | Quistgaard, E.M, Low, C, Nordlund, P. | Deposit date: | 2014-01-10 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.599 Å) | Cite: | Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol., 14, 2016
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4ODM
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![BU of 4odm by Molmil](/molmil-images/mine/4odm) | Structure of SlyD from Thermus thermophilus in complex with S2-W23A peptide | Descriptor: | 30S ribosomal protein S2, ACETATE ION, CHLORIDE ION, ... | Authors: | Quistgaard, E.M, Low, C, Nordlund, P. | Deposit date: | 2014-01-10 | Release date: | 2015-01-14 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol., 14, 2016
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4ODN
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![BU of 4odn by Molmil](/molmil-images/mine/4odn) | Structure of SlyD from Thermus thermophilus in complex with S2-plus peptide | Descriptor: | 30S ribosomal protein S2, CHLORIDE ION, GLYCEROL, ... | Authors: | Quistgaard, E.M, Low, C, Nordlund, P. | Deposit date: | 2014-01-10 | Release date: | 2015-01-14 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (1.598 Å) | Cite: | Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol., 14, 2016
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4ODK
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4ODR
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![BU of 4odr by Molmil](/molmil-images/mine/4odr) | Structure of SlyD delta-IF from Thermus thermophilus in complex with FK506 | Descriptor: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, ACETATE ION, CHLORIDE ION, ... | Authors: | Quistgaard, E.M, Low, C, Nordlund, P. | Deposit date: | 2014-01-10 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.929 Å) | Cite: | Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol., 14, 2016
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4MGV
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![BU of 4mgv by Molmil](/molmil-images/mine/4mgv) | |
4NNR
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![BU of 4nnr by Molmil](/molmil-images/mine/4nnr) | FKBP13-FK506 Complex | Descriptor: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, Peptidyl-prolyl cis-trans isomerase FKBP2 | Authors: | Schultz, L.W, Martin, P.K, Liang, J, Schreiber, S.L, Clardy, J. | Deposit date: | 2013-11-18 | Release date: | 2014-02-05 | Last modified: | 2019-11-13 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Atomic structure of the Immunophilin FKBP13-FK506 Complex: Insights into the Composite Binding Surface for Calcineurin J.Am.Chem.Soc., 116, 1994
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4ODQ
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![BU of 4odq by Molmil](/molmil-images/mine/4odq) | Structure of SlyD delta-IF from Thermus thermophilus in complex with S3 peptide | Descriptor: | 30S ribosomal protein S3, CALCIUM ION, CHLORIDE ION, ... | Authors: | Quistgaard, E.M, Low, C, Nordlund, P. | Deposit date: | 2014-01-10 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol., 14, 2016
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4ODP
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![BU of 4odp by Molmil](/molmil-images/mine/4odp) | Structure of SlyD delta-IF from Thermus thermophilus in complex with S2-W23A peptide | Descriptor: | 30S ribosomal protein S2, CALCIUM ION, CHLORIDE ION, ... | Authors: | Quistgaard, E.M, Low, C, Nordlund, P. | Deposit date: | 2014-01-10 | Release date: | 2015-01-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.747 Å) | Cite: | Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol., 14, 2016
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4N19
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![BU of 4n19 by Molmil](/molmil-images/mine/4n19) | Structural basis of conformational transitions in the active site and 80 s loop in the FK506 binding protein FKBP12 | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, SULFATE ION | Authors: | Mustafi, S.M, Brecher, M.B, Zhang, J, Li, H.M, Lemaster, D.M, Hernandez, G. | Deposit date: | 2013-10-03 | Release date: | 2014-02-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural basis of conformational transitions in the active site and 80's loop in the FK506-binding protein FKBP12. Biochem.J., 458, 2014
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1PBK
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![BU of 1pbk by Molmil](/molmil-images/mine/1pbk) | HOMOLOGOUS DOMAIN OF HUMAN FKBP25 | Descriptor: | FKBP25, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | Authors: | Liang, J, Hung, D.T, Schreiber, S.L, Clardy, J. | Deposit date: | 1995-09-01 | Release date: | 1996-10-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the human 25 kDa FK506 binding protein complexed with rapamycin. J.Am.Chem.Soc., 118, 1996
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8Z38
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![BU of 8z38 by Molmil](/molmil-images/mine/8z38) | FK506 binding protein 1B (including FK506) | Descriptor: | 6-CARBOXYPIPERIDINE, peptidylprolyl isomerase | Authors: | Liu, X.H, Zhao, W.H. | Deposit date: | 2024-04-14 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | High-resolution cocrystallized crystal structures of FK506 and FK506-binding proteins To Be Published
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9EU6
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![BU of 9eu6 by Molmil](/molmil-images/mine/9eu6) | The FK1 domain of FKBP51 in complex with SAFit-analog 23j | Descriptor: | (1,5-dimethylpyrazol-4-yl)methyl (2~{S})-1-[(2~{S})-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EUE
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![BU of 9eue by Molmil](/molmil-images/mine/9eue) | The FK1 domain of FKBP51 in complex with SAFit-analog 23a | Descriptor: | (1-methylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EU7
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![BU of 9eu7 by Molmil](/molmil-images/mine/9eu7) | The FK1 domain of FKBP51 in complex with SAFit-analog 15b | Descriptor: | (2-methyl-1,3-thiazol-5-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EUA
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![BU of 9eua by Molmil](/molmil-images/mine/9eua) | The FK1 domain of FKBP51 in complex with SAFit-analog 23d | Descriptor: | (1-propylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EUC
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![BU of 9euc by Molmil](/molmil-images/mine/9euc) | The FK1 domain of FKBP51 in complex with SAFit-analog 23b | Descriptor: | (1-ethylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EU9
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![BU of 9eu9 by Molmil](/molmil-images/mine/9eu9) | The FK1 domain of FKBP51 in complex with SAFit-analog 15i | Descriptor: | (4-chloranyl-1,3-thiazol-5-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EY4
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![BU of 9ey4 by Molmil](/molmil-images/mine/9ey4) | The FK1 domain of FKBP51 in complex with (3S,11S)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxamide | Descriptor: | (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxamide, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Krajczy, P, Hausch, F. | Deposit date: | 2024-04-09 | Release date: | 2024-06-12 | Last modified: | 2024-08-28 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins. Chemistry, 30, 2024
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9EUD
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![BU of 9eud by Molmil](/molmil-images/mine/9eud) | The FK1 domain of FKBP51 in complex with SAFit-analog 23c | Descriptor: | (1-propan-2-ylpyrazol-4-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.022 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EU8
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![BU of 9eu8 by Molmil](/molmil-images/mine/9eu8) | The FK1 domain of FKBP51 in complex with SAFit-analog 15h | Descriptor: | (4-methyl-1,3-thiazol-5-yl)methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EUB
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![BU of 9eub by Molmil](/molmil-images/mine/9eub) | The FK1 domain of FKBP51 in complex with SAFit-analog 24e | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP5, [1-(2-hydroxyethyl)pyrazol-4-yl]methyl (2S)-1-[(2S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)ethanoyl]piperidine-2-carboxylate | Authors: | Meyners, C, Buffa, V, Hausch, F. | Deposit date: | 2024-03-27 | Release date: | 2024-06-12 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | 1,4-Pyrazolyl-Containing SAFit-Analogues are Selective FKBP51 Inhibitors With Improved Ligand Efficiency and Drug-Like Profile. Chemmedchem, 19, 2024
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9EY3
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![BU of 9ey3 by Molmil](/molmil-images/mine/9ey3) | The FK1 domain of FKBP51 in complex with (3S,11S,11aS)-12-((3,5-dichlorophenyl)sulfonyl)-5-oxo-11-vinyldecahydro-1H-6,10-epiminopyrrolo[1,2-a]azonine-3-carboxylic acid | Descriptor: | (1~{S},4~{S},7~{S},8~{S},9~{R})-13-[3,5-bis(chloranyl)phenyl]sulfonyl-8-ethenyl-2-oxidanylidene-3,13-diazatricyclo[7.3.1.0^{3,7}]tridecane-4-carboxylic acid, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Meyners, C, Krajczy, P, Hausch, F. | Deposit date: | 2024-04-09 | Release date: | 2024-06-12 | Last modified: | 2024-08-28 | Method: | X-RAY DIFFRACTION (1.16 Å) | Cite: | Structure-Based Design of Ultrapotent Tricyclic Ligands for FK506-Binding Proteins. Chemistry, 30, 2024
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8Z28
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![BU of 8z28 by Molmil](/molmil-images/mine/8z28) | FK506-binding protein 1B | Descriptor: | peptidylprolyl isomerase | Authors: | Liu, X.H, Zhao, W.H. | Deposit date: | 2024-04-12 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | FK506-binding protein 1B To Be Published
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7A6X
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![BU of 7a6x by Molmil](/molmil-images/mine/7a6x) | Structure of the FKBP51FK1 domain in complex with the macrocyclic SAFit analogue 56 | Descriptor: | (2S,9S,12R)-2-cyclohexyl-12-[2-(3,4-dimethoxyphenyl)ethyl]-24,27-dimethoxy-11,18,22-trioxa-4-azatetracyclo[21.2.2.113,17.04,9]octacosa-1(25),13(28),14,16,23,26-hexaene-3,10-dione, Peptidyl-prolyl cis-trans isomerase FKBP5 | Authors: | Bauder, M, Meyners, C, Purder, P, Merz, S, Voll, A, Heymann, T, Hausch, F. | Deposit date: | 2020-08-27 | Release date: | 2021-03-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors. J.Med.Chem., 64, 2021
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