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3BD6	Glycogen Phosphorylase complex with 1(-D-ribofuranosyl) cyanuric acid Descriptor: 1-beta-D-ribofuranosyl-1,3,5-triazinane-2,4,6-trione, Glycogen phosphorylase, muscle form Authors: Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. Deposit date: 2007-11-14 Release date: 2008-11-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
2UUO	Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor Descriptor: N-{[6-(PENTYLOXY)NAPHTHALEN-2-YL]SULFONYL}-D-GLUTAMIC ACID, SULFATE ION, UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE Authors: Humljan, J, Kotnik, M, Contreras-Martel, C, Blanot, D, Urleb, U, Dessen, A, Solmajer, T, Gobec, S. Deposit date: 2007-03-06 Release date: 2008-03-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem., 51, 2008
5T68	Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine Descriptor: N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine, Tyrosine-protein kinase SYK Authors: Argiriadi, M.A, Hoemann, M, Wilson, N, Banach, D, Burchat, A, Calderwood, D, Clapham, B, Cox, P, Duignan, D.B, Konopacki, D, Somal, G, Vasudevan, A. Deposit date: 2016-09-01 Release date: 2016-10-26 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg. Med. Chem. Lett., 26, 2016
2UUP	Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor Descriptor: N-({6-[(4-CYANOBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)-D-GLUTAMIC ACID, SULFATE ION, UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE Authors: Humljan, J, Kotnik, M, Contreras-Martel, C, Blanot, D, Urleb, U, Dessen, A, Solmajer, T, Gobec, S. Deposit date: 2007-03-06 Release date: 2008-03-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem., 51, 2008
5DAA	E177K MUTANT OF D-AMINO ACID AMINOTRANSFERASE COMPLEXED WITH PYRIDOXAMINE-5'-PHOSPHATE Descriptor: D-AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE Authors: Peisach, D, Ringe, D. Deposit date: 1998-12-13 Release date: 1998-12-14 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Effects of the E177K mutation in D-amino acid transaminase. Studies on an essential coenzyme anchoring group that contributes to stereochemical fidelity. Biochemistry, 38, 1999
4MI3	Crystal structure of Gpb in complex with SUGAR (N-{(2R)-2-METHYL-3-[4-(PROPAN-2-YL)PHENYL]PROPANOYL}-BETA-D-GLUCOPYRANOSYLAMINE) (S21) Descriptor: Glycogen phosphorylase, muscle form, N-{(2R)-2-methyl-3-[4-(propan-2-yl)phenyl]propanoyl}-beta-D-glucopyranosylamine Authors: Kantsadi, L.A, Chatzileontiadou, S.M.D, Leonidas, D.D. Deposit date: 2013-08-30 Release date: 2014-07-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines. Bioorg.Med.Chem., 22, 2014
2W92	Structure of a Streptococcus pneumoniae family 85 glycoside hydrolase, Endo-D, in complex with NAG-thiazoline. Descriptor: 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, ENDO-BETA-N-ACETYLGLUCOSAMINIDASE D, PENTAETHYLENE GLYCOL Authors: Abbott, D.W, Macauley, M.S, Vocadlo, D.J, Boraston, A.B. Deposit date: 2009-01-21 Release date: 2009-01-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Streptococcus Pneumoniae Endohexosaminidase D, Structural and Mechanistic Insight Into Substrate-Assisted Catalysis in Family 85 Glycoside Hydrolases. J.Biol.Chem., 284, 2009
3KCO	Room temperature neutron structure of D-Xylose Isomerase in complex with two Ni2+ cations and d12-D-glucose in the linear form (refined jointly with X-ray structure 3KBN) Descriptor: D-glucose, NICKEL (II) ION, Xylose isomerase Authors: Kovalevsky, A.Y, Langan, P. Deposit date: 2009-10-21 Release date: 2010-06-16 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.8 Å), X-RAY DIFFRACTION Cite: Metal ion roles and the movement of hydrogen during reaction catalyzed by D-xylose isomerase: a joint x-ray and neutron diffraction study. Structure, 18, 2010
3KBN	Room temperature structure of D-Xylose Isomerase in complex with 2Ni(2+) co-factors and d12-D-glucose in the linear form Descriptor: D-glucose, NICKEL (II) ION, Xylose isomerase Authors: Kovalevsky, A.Y, Hanson, L, Langan, P. Deposit date: 2009-10-20 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Metal ion roles and the movement of hydrogen during reaction catalyzed by D-xylose isomerase: a joint x-ray and neutron diffraction study. Structure, 18, 2010
3BD8	Glucogen Phosphorylase complex with 1(-D-glucopyranosyl) cytosine Descriptor: 4-amino-1-beta-D-glucopyranosylpyrimidin-2(1H)-one, Glycogen phosphorylase, muscle form, ... Authors: Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. Deposit date: 2007-11-14 Release date: 2008-11-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
1L2G	Structure of a C-terminally truncated form of glycoprotein D from HSV-1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein D Authors: Carfi, A, Willis, S.H, Whitbeck, J.C, Krummenacher, C, Cohen, G.H, Eisenberg, R.J, Wiley, D.C. Deposit date: 2002-02-21 Release date: 2003-12-16 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Herpes simplex virus glycoprotein D bound to the human receptor HveA. Mol.Cell, 8, 2001
4MHS	Crystal structure of Gpb in complex with SUGAR (N-[(2E)-3-(BIPHENYL-4-YL)PROP-2-ENOYL]-BETA-D-GLUCOPYRANOSYLAMINE Descriptor: DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... Authors: Kantsadi, L.A, Chatzileontiadou, S.M.D, Leonidas, D.D. Deposit date: 2013-08-30 Release date: 2014-07-23 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines. Bioorg.Med.Chem., 22, 2014
3BDA	Glycogen Phosphorylase complex with 1(-D-glucopyranosyl) cyanuric acid Descriptor: 1-beta-D-glucopyranosyl-1,3,5-triazinane-2,4,6-trione, Glycogen phosphorylase, muscle form, ... Authors: Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. Deposit date: 2007-11-14 Release date: 2008-11-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
5HHD	Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21 Descriptor: D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ... Authors: Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S. Deposit date: 2016-01-10 Release date: 2016-03-09 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11, 2016
3BCS	Glycogen Phosphorylase complex with 1(-D-glucopyranosyl) uracil Descriptor: 1-beta-D-glucopyranosylpyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form Authors: Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. Deposit date: 2007-11-13 Release date: 2008-11-18 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
4AVS	Structure of N-Acetyl-L-Proline bound to Serum Amyloid P Component Descriptor: 1-ACETYL-L-PROLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Kolstoe, S, Wood, S.P. Deposit date: 2012-05-29 Release date: 2013-06-19 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.399 Å) Cite: Interaction of Serum Amyloid P Component with Hexanoyl Bis(D-Proline) (Cphpc) Acta Crystallogr.,Sect.D, 70, 2014
1XLG	MECHANISM FOR ALDOSE-KETOSE INTERCONVERSION BY D-XYLOSE ISOMERASE INVOLVING RING OPENING FOLLOWED BY A 1,2-HYDRIDE SHIFT Descriptor: ALUMINUM ION, D-XYLOSE ISOMERASE, MAGNESIUM ION, ... Authors: Collyer, C.A, Henrick, K, Blow, D.M. Deposit date: 1991-10-09 Release date: 1993-07-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Mechanism for aldose-ketose interconversion by D-xylose isomerase involving ring opening followed by a 1,2-hydride shift. J.Mol.Biol., 212, 1990
3BD7	Glycogen Phosphorylase complex with 1(-D-glucopyranosyl) thymine Descriptor: 1-beta-D-glucopyranosyl-5-methylpyrimidine-2,4(1H,3H)-dione, Glycogen phosphorylase, muscle form, ... Authors: Sovantzis, D.A, Hadjiloi, T, Hayes, J.M, Zographos, S.E, Chrysina, E.D, Oikonomakos, N.G. Deposit date: 2007-11-14 Release date: 2008-11-18 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: D-Glucopyranosyl pyrimidine nucleoside binding to muscle glycogen phosphorylase b To be Published
4CSC	STRUCTURE OF TERNARY COMPLEXES OF CITRATE SYNTHASE WITH D-AND L-MALATE: MECHANISTIC IMPLICATIONS Descriptor: ACETYL COENZYME *A, CITRATE SYNTHASE, D-MALATE Authors: Karpusas, M, Holland, D, Remington, S.J. Deposit date: 1990-05-07 Release date: 1991-04-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: 1.9-A structures of ternary complexes of citrate synthase with D- and L-malate: mechanistic implications. Biochemistry, 30, 1991
2PVP	Crystal structure of D-Alanine-D-Alanine Ligase from Helicobacter pylori Descriptor: D-alanine-D-alanine ligase Authors: Wu, D, Zhang, L, Jiang, H, Shen, X. Deposit date: 2007-05-10 Release date: 2008-04-01 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori. Proteins, 72, 2008
2VTE	Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor Descriptor: N-({7-[(4-cyanobenzyl)oxy]naphthalen-2-yl}sulfonyl)-D-glutamic acid, SULFATE ION, UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE Authors: Humljan, J, Kotnik, M, Contreras-Martel, C, Blanot, D, Urleb, U, Dessen, A, Solmajer, T, Gobec, S. Deposit date: 2008-05-14 Release date: 2008-11-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem., 51, 2008
2VTD	Crystal structure of MurD ligase in complex with D-Glu containing sulfonamide inhibitor Descriptor: N-({6-[(4-CYANO-2-FLUOROBENZYL)OXY]NAPHTHALEN-2-YL}SULFONYL)-D-GLUTAMIC ACID, SULFATE ION, UDP-N-ACETYLMURAMOYLALANINE--D-GLUTAMATE LIGASE Authors: Humljan, J, Kotnik, M, Contreras-Martel, C, Blanot, D, Urleb, U, Dessen, A, Solmajer, T, Gobec, S. Deposit date: 2008-05-14 Release date: 2008-11-25 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Novel naphthalene-N-sulfonyl-D-glutamic acid derivatives as inhibitors of MurD, a key peptidoglycan biosynthesis enzyme. J. Med. Chem., 51, 2008
3QKE	Crystal structure of D-mannonate dehydratase from Chromohalobacter Salexigens complexed with Mg and D-Gluconate Descriptor: D-gluconic acid, MAGNESIUM ION, Mandelate racemase/muconate lactonizing enzyme Authors: Fedorov, A.A, Fedorov, E.V, Wichelecki, D, Gerlt, J.A, Almo, S.C. Deposit date: 2011-02-01 Release date: 2012-02-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Cystal structure of D-mannonate dehydratase from Chromohalobacter salexigens complexed with Mg and D-Gluconate To be Published
2CSC	Structure of ternary complexes of CITRATE SYNTHASE WITH D-AND L-MALATE: mechanistic implications Descriptor: CARBOXYMETHYL COENZYME *A, CITRATE SYNTHASE, D-MALATE Authors: Karpusas, M, Holland, D, Remington, S.J. Deposit date: 1990-05-07 Release date: 1991-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: 1.9-A structures of ternary complexes of citrate synthase with D- and L-malate: mechanistic implications. Biochemistry, 30, 1991
1XIE	MODES OF BINDING SUBSTRATES AND THEIR ANALOGUES TO THE ENZYME D-XYLOSE ISOMERASE Descriptor: 1,5-anhydro-D-glucitol, D-XYLOSE ISOMERASE, MANGANESE (II) ION Authors: Carrell, H.L, Glusker, J.P. Deposit date: 1994-03-07 Release date: 1994-06-22 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Modes of binding substrates and their analogues to the enzyme D-xylose isomerase. Acta Crystallogr.,Sect.D, 50, 1994

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