4MI3
Crystal structure of Gpb in complex with SUGAR (N-{(2R)-2-METHYL-3-[4-(PROPAN-2-YL)PHENYL]PROPANOYL}-BETA-D-GLUCOPYRANOSYLAMINE) (S21)
Summary for 4MI3
Entry DOI | 10.2210/pdb4mi3/pdb |
Related | 4MHO 4MHS 4MI6 4MI9 4MIC |
Descriptor | Glycogen phosphorylase, muscle form, N-{(2R)-2-methyl-3-[4-(propan-2-yl)phenyl]propanoyl}-beta-D-glucopyranosylamine (3 entities in total) |
Functional Keywords | alpha and beta protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Total number of polymer chains | 1 |
Total formula weight | 95876.47 |
Authors | Kantsadi, L.A.,Chatzileontiadou, S.M.D.,Leonidas, D.D. (deposition date: 2013-08-30, release date: 2014-07-23, Last modification date: 2023-12-06) |
Primary citation | Parmenopoulou, V.,Kantsadi, A.L.,Tsirkone, V.G.,Chatzileontiadou, D.S.,Manta, S.,Zographos, S.E.,Molfeta, C.,Archontis, G.,Agius, L.,Hayes, J.M.,Leonidas, D.D.,Komiotis, D. Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines. Bioorg.Med.Chem., 22:4810-4825, 2014 Cited by PubMed: 25092521DOI: 10.1016/j.bmc.2014.06.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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