5HMZ
 
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 23 | | Descriptor: | 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4-methoxy-2-methyl-N-(methylsulfonyl)benzamide, RNA-directed RNA polymerase NS5, ZINC ION | | Authors: | Noble, C.G. | | Deposit date: | 2016-01-17 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design
J.Med.Chem., 59, 2016
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7SIR
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2R75
 | | Aquifex aeolicus FtsZ with 8-morpholino-GTP | | Descriptor: | 8-morpholin-4-ylguanosine 5'-(tetrahydrogen triphosphate), Cell division protein ftsZ, MAGNESIUM ION | | Authors: | Lappchen, T, Pinas, V.A, Hartog, A.F, Koomen, G.J, Schaffner-Barbero, C, Andreu, J.M, Trambaiolo, D, Lowe, J, Juhem, A, Popov, A.V, den Blaauwen, T. | | Deposit date: | 2007-09-07 | | Release date: | 2008-07-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.402 Å) | | Cite: | Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites
Chem.Biol., 15, 2008
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7DCL
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2FY9
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7SIQ
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6X8O
 | | BimBH3 peptide tetramer | | Descriptor: | Bcl-2-like protein 11, THIOCYANATE ION | | Authors: | Robin, A.Y, Westphal, D, Uson, I, Czabotar, P.E. | | Deposit date: | 2020-06-01 | | Release date: | 2020-09-09 | | Last modified: | 2021-02-17 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Biophysical Characterization of Pro-apoptotic BimBH3 Peptides Reveals an Unexpected Capacity for Self-Association.
Structure, 29, 2021
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2G15
 | | Structural Characterization of autoinhibited c-Met kinase | | Descriptor: | activated met oncogene | | Authors: | Wang, W, Marimuthu, A, Tsai, J, Kumar, A, Krupka, H.I, Zhang, C, Powell, B, Suzuki, Y, Nguyen, H, Tabrizizad, M, Luu, C, West, B.L. | | Deposit date: | 2006-02-13 | | Release date: | 2006-03-21 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
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2R8V
 | | Native structure of N-acetylglutamate synthase from Neisseria gonorrhoeae | | Descriptor: | ACETYL COENZYME *A, Putative acetylglutamate synthase | | Authors: | Shi, D, Sagar, V, Jin, Z, Yu, X, Caldovic, L, Morizono, H, Allewell, N.M, Tuchman, M. | | Deposit date: | 2007-09-11 | | Release date: | 2008-01-15 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of N-acetyl-L-glutamate synthase from Neisseria gonorrhoeae provides insights into mechanisms of catalysis and regulation.
J.Biol.Chem., 283, 2008
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5HPC
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2RAO
 | | X ray crystal structure of rabbit hemoglobin (oxy form) at 2.0 angstrom resolution | | Descriptor: | Hemoglobin subunit alpha-1/2, Hemoglobin subunit beta-1/2, OXYGEN MOLECULE, ... | | Authors: | Sundaresan, S, Packianathan, C, Neelagandan, K, Ponnuswamy, M.N. | | Deposit date: | 2007-09-17 | | Release date: | 2008-09-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | X-ray crystal structure determination of hemoglobin from rabbit at 2.0 angstrom resloution
To be Published
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5HZU
 | | Crystal structure of Dronpa-Ni2+ | | Descriptor: | Fluorescent protein Dronpa, NICKEL (II) ION | | Authors: | Hwang, K.Y, Nam, K.H. | | Deposit date: | 2016-02-03 | | Release date: | 2017-03-15 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystal structures of Dronpa complexed with quenchable metal ions provide insight into metal biosensor development
FEBS Lett., 590, 2016
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5HJX
 | | Structure function studies of R. palustris RubisCO (A47V mutant; CABP-bound) | | Descriptor: | 2-CARBOXYARABINITOL-1,5-DIPHOSPHATE, MAGNESIUM ION, Ribulose bisphosphate carboxylase | | Authors: | Arbing, M.A, Shin, A, Satagopan, S, North, J.A, Tabita, F.R. | | Deposit date: | 2016-01-13 | | Release date: | 2017-01-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.799 Å) | | Cite: | Structure function studies of R. palustris RubisCO.
To Be Published
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7RWK
 | | Structure of Cap5 from Asticcacaulis sp. | | Descriptor: | MAGNESIUM ION, SAVED domain-containing protein, ZINC ION | | Authors: | Huang, R.H, Fatma, S, Chakravarti, A. | | Deposit date: | 2021-08-20 | | Release date: | 2021-11-10 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger.
Nat Commun, 12, 2021
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2RDM
 | | Crystal structure of response regulator receiver protein from Sinorhizobium medicae WSM419 | | Descriptor: | GLYCEROL, Response regulator receiver protein | | Authors: | Patskovsky, Y, Yan, Q, Zhan, C, Toro, R, Meyer, A.J, Gilmore, M, Hu, S, Groshong, C, Rodgers, L, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2007-09-24 | | Release date: | 2007-10-09 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Crystal structure of response regulator receiver protein from Sinorhizobium medicae WSM419.
To be Published
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2G64
 | | Structure of Caenorhabditis elegans 6-pyruvoyl tetrahydropterin synthase | | Descriptor: | GLYCEROL, Putative 6-pyruvoyl tetrahydrobiopterin synthase, SODIUM ION, ... | | Authors: | Wengerter, B.C, Patskovsky, Y, Zhan, C, Ramagopal, U, Milstein, S, Vidal, M, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2006-02-24 | | Release date: | 2006-03-14 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of Caenorhabditis Elegans 6-Pyruvoyl Tetrahydropterin Synthase
To be Published
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2G1E
 | | Solution Structure of TA0895 | | Descriptor: | hypothetical protein Ta0895 | | Authors: | Yeo, I.Y, Hong, E, Jung, J, Lee, W, Yee, A, Arrowsmith, C.H. | | Deposit date: | 2006-02-14 | | Release date: | 2006-12-26 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of TA0895, a MoaD homologue from Thermoplasma acidophilum
Proteins, 65, 2006
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5HRP
 | | HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002 | | Descriptor: | (2S)-tert-butoxy[1-(3,4-difluorobenzyl)-6-methyl-4-(5-methyl-3,4-dihydro-2H-chromen-6-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]acetic acid, 1,2-ETHANEDIOL, CACODYLATE ION, ... | | Authors: | Nolte, R.T. | | Deposit date: | 2016-01-24 | | Release date: | 2016-12-14 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
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5HMK
 | | HDM2 in complex with a 3,3-Disubstituted Piperidine | | Descriptor: | E3 ubiquitin-protein ligase Mdm2, {4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-3-[4-(trifluoromethyl)phenoxy]-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}piperidin-3-yl]methanone | | Authors: | Scapin, G. | | Deposit date: | 2016-01-16 | | Release date: | 2016-04-06 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Acs Med.Chem.Lett., 7, 2016
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5HMM
 | | Crystal Structure of T5 D15 Protein Co-crystallized with Metal Ions | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Exodeoxyribonuclease, ... | | Authors: | Flemming, C.S, Sedelnikova, S.E, Rafferty, J.B, Sayers, J.R, Artymiuk, P.J. | | Deposit date: | 2016-01-16 | | Release date: | 2016-06-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Direct observation of DNA threading in flap endonuclease complexes.
Nat.Struct.Mol.Biol., 23, 2016
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2G6O
 | | Structure of bovine eNOS heme domain (BH4-free) complexed with CO | | Descriptor: | ACETATE ION, ARGININE, CACODYLATE ION, ... | | Authors: | Li, H, Igarashi, J, Jamal, J, Yang, W, Poulos, T.L. | | Deposit date: | 2006-02-24 | | Release date: | 2006-08-08 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
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7RWM
 | | Structure of Cap5 from Lactococcus lactis | | Descriptor: | SAVED domain-containing protein, ZINC ION | | Authors: | Huang, R.H, Fatma, S, Chakravarti, A. | | Deposit date: | 2021-08-20 | | Release date: | 2021-11-10 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3',2'-cGAMP as the second messenger.
Nat Commun, 12, 2021
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2G77
 | | Crystal Structure of Gyp1 TBC domain in complex with Rab33 GTPase bound to GDP and AlF3 | | Descriptor: | ALUMINUM FLUORIDE, GTPase-activating protein GYP1, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Pan, X, Eathiraj, S, Munson, M, Lambright, D.G. | | Deposit date: | 2006-02-27 | | Release date: | 2006-07-25 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger mechanism.
Nature, 442, 2006
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5HMY
 | | Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15 | | Descriptor: | 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, RNA-directed RNA polymerase NS5, ZINC ION | | Authors: | Noble, C.G. | | Deposit date: | 2016-01-17 | | Release date: | 2016-03-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.
J.Med.Chem., 59, 2016
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5HNA
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