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3FTY	Leukotriene A4 hydrolase in complex with fragment 3-(benzyloxy)pyridin-2-amine Descriptor: 3-(BENZYLOXY)PYRIDIN-2-AMINE, ACETATE ION, IMIDAZOLE, ... Authors: Davies, D.R. Deposit date: 2009-01-13 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUF	Leukotriene A4 hydrolase in complex with fragment 5-fluoroindole and bestatin Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 5-fluoro-1H-indole, IMIDAZOLE, ... Authors: Davies, D.R. Deposit date: 2009-01-14 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
4DFM	Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in ternary complex with 5-(aminopentinyl)-2-dCTP Descriptor: 1,2-ETHANEDIOL, 5'-d(AAAGCGCGCCGTGGTC)-3', 5'-d(GACCACGGCGC ddG)-3', ... Authors: Bergen, K, Steck, A, Struett, S, Baccaro, A, Welte, W, Diederichs, K, Marx, A. Deposit date: 2012-01-24 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.886 Å) Cite: Structures of KlenTaq DNA Polymerase Caught While Incorporating C5-Modified Pyrimidine and C7-Modified 7-Deazapurine Nucleoside Triphosphates. J.Am.Chem.Soc., 134, 2012
4DN0	PelD 156-455 from Pseudomonas aeruginosa PA14 in complex with c-di-GMP Descriptor: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Putative uncharacterized protein pelD, SODIUM ION, ... Authors: Whitney, J.C, Colvin, K.M, Marmont, L.S, Robinson, H, Parsek, M.R, Howell, P.L. Deposit date: 2012-02-08 Release date: 2012-05-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa. J.Biol.Chem., 287, 2012
3P5M	Crystal structure of an enoyl-CoA hydratase/isomerase from Mycobacterium avium Descriptor: 1,2-ETHANEDIOL, Enoyl-CoA hydratase/isomerase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-10-08 Release date: 2010-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3FU3	Leukotriene A4 hydrolase in complex with fragment 4-(2-amino-1,3-thiazol-4-yl)phenol Descriptor: 4-(2-amino-1,3-thiazol-4-yl)phenol, ACETATE ION, IMIDAZOLE, ... Authors: Davies, D.R. Deposit date: 2009-01-13 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUK	Leukotriene A4 hydrolase in complex with 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid Descriptor: 1-[2-(1H-indol-5-yloxy)ethyl]piperidine-4-carboxylic acid, ACETATE ION, IMIDAZOLE, ... Authors: Davies, D.R. Deposit date: 2009-01-14 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
5WB8	Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, Epigen, ... Authors: Bessman, N.J, Freed, D.M, Moore, J.O, Ferguson, K.M, Lemmon, M.A. Deposit date: 2017-06-28 Release date: 2017-10-18 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3 Å) Cite: EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell, 171, 2017
2OEL	Crystal structure of a rubisco-like protein from Geobacillus kaustophilus liganded with Mg2+ and HCO3- ions Descriptor: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, CARBONATE ION, MAGNESIUM ION Authors: Fedorov, A.A, Imker, H.J, Fedorov, E.V, Almo, S.C, Gerlt, J.A. Deposit date: 2006-12-30 Release date: 2007-03-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Mechanistic Diversity in the RuBisCO Superfamily: The "Enolase" in the Methionine Salvage Pathway in Geobacillus kaustophilus. Biochemistry, 46, 2007
3ONW	Structure of a G-alpha-i1 mutant with enhanced affinity for the RGS14 GoLoco motif. Descriptor: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, ... Authors: Bosch, D, Kimple, A.J, Sammond, D.W, Miley, M.J, Machius, M, Kuhlman, B, Willard, F.S, Siderovski, D.P. Deposit date: 2010-08-30 Release date: 2010-11-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.38 Å) Cite: Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants. J.Biol.Chem., 286, 2011
2O0L	Human spermidine synthase Descriptor: 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, Spermidine synthase Authors: Min, J, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) Deposit date: 2006-11-27 Release date: 2006-12-12 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structure and mechanism of spermidine synthases. Biochemistry, 46, 2007
4EMD	Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to CMP and SO4 Descriptor: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, CYTIDINE-5'-MONOPHOSPHATE, SULFATE ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-04-11 Release date: 2012-04-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4X4V	Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC and AMPcPP Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CCA-adding enzyme, D(-)-TARTARIC ACID, ... Authors: Kuhn, C.-D, Joshua-Tor, L. Deposit date: 2014-12-03 Release date: 2015-02-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme. Cell, 160, 2015
3FU0	Leukotriene A4 hydrolase in complex with fragment 4-(4-fluorobenzoyl)pyridine Descriptor: (4-fluorophenyl)(pyridin-4-yl)methanone, ACETATE ION, IMIDAZOLE, ... Authors: Davies, D.R. Deposit date: 2009-01-13 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUH	Leukotriene A4 hydrolase in complex with fragment 5-hydroxyindole and bestatin Descriptor: 1H-indol-5-ol, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, IMIDAZOLE, ... Authors: Davies, D.R. Deposit date: 2009-01-14 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
4EGE	Crystal Structure of Dipeptidase PepE from Mycobacterium ulcerans Descriptor: 1,2-ETHANEDIOL, Dipeptidase PepE, UNKNOWN ATOM OR ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-03-30 Release date: 2012-04-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3FTX	Leukotriene A4 hydrolase in complex with dihydroresveratrol and bestatin Descriptor: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol, ACETATE ION, ... Authors: Davies, D.R. Deposit date: 2009-01-13 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
5WSC	Crystal of pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, soaked with allosteric activators AMP and Glucose 6-Phosphate Descriptor: 6-O-phosphono-alpha-D-glucopyranose, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... Authors: Zhong, W, Cai, Q, El Sahili, A, Lescar, J, Dedon, P.C. Deposit date: 2016-12-06 Release date: 2017-11-15 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8, 2017
7AL7	The Crystal Structure of Human IL-18 in Complex With Human IL-18 Binding Protein Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutathione S-transferase class-mu 26 kDa isozyme,Interleukin-18, Interleukin-18-binding protein Authors: Detry, S, Andries, J, Bloch, Y, Clancy, D, Savvides, S.N. Deposit date: 2020-10-05 Release date: 2022-04-20 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.801 Å) Cite: Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity. J.Biol.Chem., 298, 2022
3FUI	Leukotriene A4 hydrolase in complex with N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline Descriptor: IMIDAZOLE, Leukotriene A-4 hydrolase, N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline, ... Authors: Davies, D.R. Deposit date: 2009-01-14 Release date: 2009-07-28 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
4X4R	Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACC and AMPcPP Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CCA-adding enzyme, D(-)-TARTARIC ACID, ... Authors: Kuhn, C.-D, Joshua-Tor, L. Deposit date: 2014-12-03 Release date: 2015-02-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.202 Å) Cite: On-Enzyme Refolding Permits Small RNA and tRNA Surveillance by the CCA-Adding Enzyme. Cell, 160, 2015
3P85	Crystal structure enoyl-coa hydratase from mycobacterium avium Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CACODYLATE ION, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2010-10-13 Release date: 2010-11-03 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
4WRQ	Crystal Structure of 14-3-3 zeta with Chibby peptide Descriptor: 14-3-3 protein zeta/delta, Chibby Authors: Killoran, R.C, Shilton, B.H, Choy, W.Y. Deposit date: 2014-10-24 Release date: 2015-05-06 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.409 Å) Cite: Structural Analysis of the 14-3-3 zeta /Chibby Interaction Involved in Wnt/ beta-Catenin Signaling. Plos One, 10, 2015
5WS9	Pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, ATP and allosteric activator AMP Descriptor: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Zhong, W, Cai, Q, El Sahili, A, Lescar, J, Dedon, P.C. Deposit date: 2016-12-06 Release date: 2017-11-15 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis. Nat Commun, 8, 2017
7B7A	ENDO-POLYGALACTURONASE FROM ARABIDOPSIS THALIANA Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Pectin lyase-like superfamily protein, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Safran, J, Tabi, W, Habrylo, O, Bouckaert, J, Lefebvre, V, Senechal, F, Pelloux, J. Deposit date: 2020-12-10 Release date: 2022-06-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Plant polygalacturonase structures specify enzyme dynamics and processivities to fine-tune cell wall pectins. Plant Cell, 2023

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