8K5B
 
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8KG8
 | | Yeast replisome in state II | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (4.23 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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6GX7
 | | Tubulin-CopN-alphaRep complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Gigant, B, Campanacci, V. | | Deposit date: | 2018-06-26 | | Release date: | 2019-04-24 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | Insight into microtubule nucleation from tubulin-capping proteins.
Proc.Natl.Acad.Sci.USA, 116, 2019
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6GJB
 | | Erk2 signalling protein | | Descriptor: | Mitogen-activated protein kinase 1, SULFATE ION, [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[4-[1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-2-oxidanylidene-pyridin-4-yl]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate | | Authors: | O'Reilly, M. | | Deposit date: | 2018-05-16 | | Release date: | 2019-01-02 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe.
Chem Sci, 9, 2018
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8KG9
 | | Yeast replisome in state III | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (4.52 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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2OGZ
 | | Crystal structure of DPP-IV complexed with Lilly aryl ketone inhibitor | | Descriptor: | 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE, Dipeptidyl peptidase | | Authors: | Timm, D.E. | | Deposit date: | 2007-01-09 | | Release date: | 2007-03-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.
Bioorg.Med.Chem.Lett., 17, 2007
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8K6X
 | | Crystal structure of E.coli Cyanase complex with cyanate and bicarbonate | | Descriptor: | CARBONATE ION, Cyanate hydratase, SULFATE ION, ... | | Authors: | Kim, J, Nam, K.H, Cho, Y. | | Deposit date: | 2023-07-25 | | Release date: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural mechanism of Escherichia coli cyanase.
Acta Crystallogr D Struct Biol, 79, 2023
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8K6U
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8KG6
 | | Yeast replisome in state I | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... | | Authors: | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | Deposit date: | 2023-08-17 | | Release date: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8K6S
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8K6G
 | | Crystal structure of E.coli Cyanase | | Descriptor: | Cyanate hydratase, SULFATE ION | | Authors: | Kim, J, Nam, K.H, Cho, Y. | | Deposit date: | 2023-07-25 | | Release date: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural mechanism of Escherichia coli cyanase.
Acta Crystallogr D Struct Biol, 79, 2023
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8K6H
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6GSD
 | | Plantago Major multifunctional oxidoreductase in complex with progesterone and NADP+ | | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROGESTERONE, Progesterone 5-beta-reductase | | Authors: | Fellows, R, Silva, C, Russo, C.M, Lee, S.G, Jez, J.M, Chisholm, J.D, Zubieta, C, Nanao, M. | | Deposit date: | 2018-06-14 | | Release date: | 2018-10-17 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamily.
Sci Rep, 8, 2018
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6GVT
 | | Hybrid structure of the pRN1 helix bundle domain in complex with DNA and 2 ATP molecules | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*TP*GP*TP*GP*CP*TP*CP*A)-3'), MAGNESIUM ION, ... | | Authors: | Boudet, J, Wiegand, T, Meier, B.H, Lipps, G, Allain, F.H.-T. | | Deposit date: | 2018-06-21 | | Release date: | 2018-12-26 | | Last modified: | 2019-08-21 | | Method: | SOLID-STATE NMR, SOLUTION NMR | | Cite: | A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template.
Cell, 176, 2019
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2O0I
 | | crystal structure of the R185A mutant of the N-terminal domain of the Group B Streptococcus Alpha C protein | | Descriptor: | C protein alpha-antigen | | Authors: | Hogle, J.M, Filman, D.J, Baron, M.J, Madoff, L.C, Iglesias, A. | | Deposit date: | 2006-11-27 | | Release date: | 2007-02-06 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Identification of a glycosaminoglycan binding region of the alpha C protein that mediates entry of group B streptococci into host cells.
J.Biol.Chem., 282, 2007
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6GXP
 | | Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP(RF3-only) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Graf, M, Huter, P, Maracci, C, Peterek, M, Rodnina, M.V, Wilson, D.N. | | Deposit date: | 2018-06-27 | | Release date: | 2018-08-15 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1.
Nat Commun, 9, 2018
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2O72
 | | Crystal Structure Analysis of human E-cadherin (1-213) | | Descriptor: | CALCIUM ION, Epithelial-cadherin | | Authors: | Parisini, E, Wang, J.-H. | | Deposit date: | 2006-12-09 | | Release date: | 2007-10-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Crystal Structure of Human E-cadherin Domains 1 and 2, and Comparison with other Cadherins in the Context of Adhesion Mechanism
J.Mol.Biol., 373, 2007
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8JSH
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8JSG
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5OK3
 | | Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp241 and Fasudil | | Descriptor: | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, UPF0418 protein FAM164A, cAMP-dependent protein kinase catalytic subunit alpha | | Authors: | Mueller, J.M, Heine, A, Klebe, G. | | Deposit date: | 2017-07-25 | | Release date: | 2018-08-08 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.588 Å) | | Cite: | Diamondoid Amino Acid-Based Peptide Kinase A Inhibitor Analogues.
Chemmedchem, 14, 2019
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6GXO
 | | Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and P/E-tRNA (State IV) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Graf, M, Huter, P, Maracci, C, Peterek, M, Rodnina, M.V, Wilson, D.N. | | Deposit date: | 2018-06-27 | | Release date: | 2018-08-15 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1.
Nat Commun, 9, 2018
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6GRN
 | | CELLOBIOHYDROLASE I (CEL7A) FROM Trichoderma reesei with S-dihydroxypropranolol in the active site | | Descriptor: | 2-[[(2~{S})-3-naphthalen-1-yloxy-2-oxidanyl-propyl]amino]propane-1,3-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, ... | | Authors: | Sandgren, M, Fagerstrom, A, Widmalm, G, Stahlberg, J. | | Deposit date: | 2018-06-11 | | Release date: | 2018-10-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Enantioselective Binding of Propranolol and Analogues Thereof to Cellobiohydrolase Cel7A.
Chemistry, 24, 2018
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6GWP
 | | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) | | Descriptor: | Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64 | | Authors: | Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | | Deposit date: | 2018-06-25 | | Release date: | 2020-01-01 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
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6GZR
 | | Solution NMR structure of the tetramethylrhodamine (TMR) aptamer 3 in complex with 5-TAMRA | | Descriptor: | 5-carboxy methylrhodamine, tetramethylrhodamine aptamer | | Authors: | Duchardt-Ferner, E, Ohlenschlager, O, Kreutz, C.R, Wohnert, J. | | Deposit date: | 2018-07-05 | | Release date: | 2019-07-17 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine.
Nucleic Acids Res., 48, 2020
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6GWT
 | | Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State I) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Graf, M, Huter, P, Maracci, C, Peterek, M, Rodnina, M.V, Wilson, D.N. | | Deposit date: | 2018-06-25 | | Release date: | 2018-08-15 | | Last modified: | 2019-02-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1.
Nat Commun, 9, 2018
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