6GJB
Erk2 signalling protein
Summary for 6GJB
Entry DOI | 10.2210/pdb6gjb/pdb |
Descriptor | Mitogen-activated protein kinase 1, SULFATE ION, [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[4-[1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-2-oxidanylidene-pyridin-4-yl]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate, ... (4 entities in total) |
Functional Keywords | erk2, inhibitor, reversible probe, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43689.37 |
Authors | |
Primary citation | Lebraud, H.,Surova, O.,Courtin, A.,O'Reilly, M.,Valenzano, C.R.,Nordlund, P.,Heightman, T.D. Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe. Chem Sci, 9:8608-8618, 2018 Cited by PubMed: 30568786DOI: 10.1039/c8sc02754d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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