PDB: 19255 resultsInfo pagesStatus searchChemie searchBIRD

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8GIP	Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.040mM Mn2+ Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, MAGNESIUM ION, ... Authors: Wu, S, Sohn, J. Deposit date: 2023-03-14 Release date: 2024-05-22 Last modified: 2024-05-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS. Nat Commun, 15, 2024
2NR0	Crystal structure of pseudoudirinde synthase TruA in complex with leucyl tRNA Descriptor: leucyl tRNA, tRNA pseudouridine synthase A Authors: Hur, S, Stroud, R.M. Deposit date: 2006-11-01 Release date: 2007-05-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.9 Å) Cite: How U38, 39, and 40 of Many tRNAs Become the Targets for Pseudouridylation by TruA. Mol.Cell, 26, 2007
8J6L	Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... Authors: Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. Deposit date: 2023-04-26 Release date: 2024-04-03 Method: ELECTRON MICROSCOPY (3.05 Å) Cite: Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
6GDQ	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: 4-[5-chloranyl-2-(propan-2-ylamino)pyridin-4-yl]-~{N}-[(1~{S})-1-(3-chlorophenyl)-2-oxidanyl-ethyl]-1~{H}-pyrrole-2-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... Authors: O'Reilly, M. Deposit date: 2018-04-24 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
8J74	Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation, dimeric state Descriptor: (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), CHOLESTEROL HEMISUCCINATE, HEXADECANE, ... Authors: Gao, Y, Qiu, Y, Zhao, Y. Deposit date: 2023-04-27 Release date: 2024-04-03 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Transport mechanism of presynaptic high-affinity choline uptake by CHT1. Nat.Struct.Mol.Biol., 31, 2024
2OJG	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide Descriptor: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION Authors: Xie, X, Jacobs, M.D. Deposit date: 2007-01-12 Release date: 2007-02-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
8J29	Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2A	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ Descriptor: GLYCEROL, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2D	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ Descriptor: GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2C	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R Descriptor: GLYCEROL, L(+)-TARTARIC ACID, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8J2E	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, mutant N940V/K1106W/S1114R in complex with NADP+ and malonate Descriptor: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
8EYQ	30S_delta_ksgA_h44_inactive_conformation Descriptor: 16S_rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... Authors: Ortega, J, Sun, J. Deposit date: 2022-10-28 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion. Nat.Struct.Mol.Biol., 30, 2023
8J2B	Structure of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus, in complex with NADP+ and malonate Descriptor: MALONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Short-chain dehydrogenase/reductase SDR Authors: Ma, Q, Liu, C. Deposit date: 2023-04-14 Release date: 2024-04-17 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Structures of the C-terminal subenzyme of the malonyl-CoA reductase from Chloroflexus aurantiacus To Be Published
6G9D	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]ethanamide Authors: O'Reilly, M. Deposit date: 2018-04-10 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
2NX7	Structure of NOWA cysteine rich domain 8 Descriptor: Nematocyst outer wall antigen Authors: Meier, S, Jensen, P.R, Adamczyk, P, Bachinger, H.P, Holstein, T.W, Engel, J, Ozbek, S, Grzesiek, S. Deposit date: 2006-11-17 Release date: 2007-10-02 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall. J.Mol.Biol., 368, 2007
6G9M	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-(2-phenylpropan-2-yl)ethanamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: O'Reilly, M. Deposit date: 2018-04-11 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
6GAK	Crystal structure of the T1L reovirus sigma1 coiled coil tail (chloride) Descriptor: CHLORIDE ION, Outer capsid protein sigma-1 Authors: Dietrich, M.H, Stehle, T. Deposit date: 2018-04-11 Release date: 2018-04-25 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.43 Å) Cite: Structural and Functional Features of the Reovirus sigma 1 Tail. J. Virol., 92, 2018
6FUF	Crystal structure of the rhodopsin-mini-Go complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(o) subunit alpha, RETINAL, ... Authors: Tsai, C.-J, Weinert, T, Muehle, J, Pamula, F, Nehme, R, Flock, T, Nogly, P, Edwards, P.C, Carpenter, B, Gruhl, T, Ma, P, Deupi, X, Standfuss, J, Tate, C.G, Schertler, G.F.X. Deposit date: 2018-02-27 Release date: 2018-10-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.117 Å) Cite: Crystal structure of rhodopsin in complex with a mini-Gosheds light on the principles of G protein selectivity. Sci Adv, 4, 2018
6GDM	Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2 Descriptor: (3~{R})-1-[2-oxidanylidene-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-~{N}-(3-pyridin-4-yl-1~{H}-indazol-5-yl)pyrrolidine-3-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... Authors: O'Reilly, M. Deposit date: 2018-04-24 Release date: 2018-05-30 Last modified: 2018-06-27 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J. Med. Chem., 61, 2018
8EYT	30S_delta_ksgA+KsgA complex Descriptor: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... Authors: Sun, J, Kinman, L.F, Jahagirdar, D, Ortega, J, Davis, J.H. Deposit date: 2022-10-28 Release date: 2023-09-06 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: KsgA facilitates ribosomal small subunit maturation by proofreading a key structural lesion. Nat.Struct.Mol.Biol., 30, 2023
8FI2	Structure of Lettuce C20T bound to DFHBI-1T Descriptor: (5Z)-5-(3,5-difluoro-4-hydroxybenzylidene)-2-methyl-3-(2,2,2-trifluoroethyl)-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2022-12-15 Release date: 2023-05-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3 Å) Cite: Intricate 3D architecture of a DNA mimic of GFP. Nature, 618, 2023
8F8Q	Cryo-EM structure of the CapZ-capped barbed end of F-actin Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... Authors: Carman, P.J, Barrie, K.R, Dominguez, R. Deposit date: 2022-11-22 Release date: 2023-06-07 Last modified: 2023-07-05 Method: ELECTRON MICROSCOPY (2.79 Å) Cite: Structures of the free and capped ends of the actin filament. Science, 380, 2023
8FI1	Structure of Lettuce C20G bound to DFHO Descriptor: (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2022-12-15 Release date: 2023-05-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Intricate 3D architecture of a DNA mimic of GFP. Nature, 618, 2023
8FI0	Structure of Lettuce aptamer bound to DFAME Descriptor: Lettuce DNA aptamer, MAGNESIUM ION, POTASSIUM ION, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2022-12-15 Release date: 2023-05-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (3 Å) Cite: Intricate 3D architecture of a DNA mimic of GFP. Nature, 618, 2023
8FI7	Structure of Lettuce C20T bound to DFHO Descriptor: (5Z)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-2-[(E)-(hydroxyimino)methyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one, Lettuce DNA aptamer, MAGNESIUM ION, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2022-12-15 Release date: 2023-05-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Intricate 3D architecture of a DNA mimic of GFP. Nature, 618, 2023

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