4AE9
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![BU of 4ae9 by Molmil](/molmil-images/mine/4ae9) | Structure and function of the Human Sperm-Specific Isoform of Protein Kinase A (PKA) Catalytic Subunit C alpha 2 | Descriptor: | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA | Authors: | Hereng, T.H, Backe, P.H, Kahmann, J, Scheich, C, Bjoras, M, Skalhegg, B.S, Rosendal, K.R. | Deposit date: | 2012-01-09 | Release date: | 2012-04-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and Function of the Human Sperm-Specific Isoform of Protein Kinase a (Pka) Catalytic Subunit Calpha2 J.Struct.Biol., 178, 2012
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7SPZ
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![BU of 7spz by Molmil](/molmil-images/mine/7spz) | Nucleotide-free Get3 in two open forms | Descriptor: | ATPase ASNA1 homolog, ZINC ION | Authors: | Fry, M.Y, Maggiolo, A.O, Clemons Jr, W.M. | Deposit date: | 2021-11-04 | Release date: | 2022-07-20 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structurally derived universal mechanism for the catalytic cycle of the tail-anchored targeting factor Get3. Nat.Struct.Mol.Biol., 29, 2022
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7T31
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![BU of 7t31 by Molmil](/molmil-images/mine/7t31) | X-ray Structure of Clostridiodies difficile PilW | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Putative pilin protein chimera | Authors: | Ronish, L.A, Piepenbrink, K.H. | Deposit date: | 2021-12-06 | Release date: | 2022-10-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Recognition of extracellular DNA by type IV pili promotes biofilm formation by Clostridioides difficile. J.Biol.Chem., 298, 2022
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6PSJ
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6PV4
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![BU of 6pv4 by Molmil](/molmil-images/mine/6pv4) | Structure of CpGH84A | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Glycoside Hydrolase | Authors: | Pluvinage, B, Boraston, A.B. | Deposit date: | 2019-07-19 | Release date: | 2019-09-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and functional analysis of four family 84 glycoside hydrolases from the opportunistic pathogen Clostridium perfringens. Glycobiology, 30, 2019
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7TT8
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![BU of 7tt8 by Molmil](/molmil-images/mine/7tt8) | Human LRH-1 LBD bound to agonist 6N-10CA and fragment of Tif2 coactivator | Descriptor: | 10-[(3aR,6S,6aR)-3-phenyl-3a-(1-phenylethenyl)-6-(sulfamoylamino)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid (non-preferred name), Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | Authors: | Cato, M.L, Ortlund, E.A. | Deposit date: | 2022-01-31 | Release date: | 2022-05-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. J.Med.Chem., 65, 2022
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5N7G
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![BU of 5n7g by Molmil](/molmil-images/mine/5n7g) | MAGI-1 complexed with a synthetic pRSK1 peptide | Descriptor: | CALCIUM ION, GLYCEROL, Membrane-associated guanylate kinase, ... | Authors: | Gogl, G, Nyitray, L. | Deposit date: | 2017-02-20 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Dynamic control of RSK complexes by phosphoswitch-based regulation. FEBS J., 285, 2018
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6Q1N
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![BU of 6q1n by Molmil](/molmil-images/mine/6q1n) | Glucocerebrosidase in complex with pharmacological chaperone IMX8 | Descriptor: | (2R,3S,4S,5R)-2-[2-(methylsulfanyl)ethyl]piperidine-3,4,5-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Vickers, C, Withers, S.G, Boraston, A.B. | Deposit date: | 2019-08-05 | Release date: | 2020-08-19 | Method: | X-RAY DIFFRACTION (2.526 Å) | Cite: | Pharmacological chaperones for GCase that switch conformation with pH enhance enzyme levels in Gaucher animal models. To Be Published
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6Q6K
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![BU of 6q6k by Molmil](/molmil-images/mine/6q6k) | Crystal structure of recombinant human beta-glucocerebrosidase in complex with cyclophellitol activity based probe with Cy5 tag (ME569) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[3,3-dimethyl-2-[(1~{E},3~{E},5~{E})-5-(1,3,3-trimethylindol-2-ylidene)penta-1,3-dienyl]indol-1-ium-1-yl]-~{N}-[[1-[[(1~{S},2~{R},3~{R},4~{S},6~{S})-2,3,4,6-tetrakis(oxidanyl)cyclohexyl]methyl]-1,2,3-triazol-4-yl]methyl]hexanamide, ... | Authors: | Rowland, R.J, Davies, G.J. | Deposit date: | 2018-12-11 | Release date: | 2019-03-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish. J.Am.Chem.Soc., 141, 2019
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7C83
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![BU of 7c83 by Molmil](/molmil-images/mine/7c83) | Crystal structure of an integral membrane steroid 5-alpha-reductase PbSRD5A | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-oxo-5-alpha-steroid 4-dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Ren, R.B, Han, Y.F, Xiao, Q.J, Deng, D. | Deposit date: | 2020-05-28 | Release date: | 2021-01-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism. Nat Commun, 12, 2021
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6XP7
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5LIW
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![BU of 5liw by Molmil](/molmil-images/mine/5liw) | Crystal structure of human AKR1B10 complexed with NADP+ and the inhibitor MK319 | Descriptor: | 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Fanfrlik, J, Kamlar, M, Vesely, J, Hobza, P, Podjarny, A. | Deposit date: | 2016-07-15 | Release date: | 2016-07-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. Acs Chem.Biol., 11, 2016
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4A1G
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![BU of 4a1g by Molmil](/molmil-images/mine/4a1g) | The crystal structure of the human Bub1 TPR domain in complex with the KI motif of Knl1 | Descriptor: | MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1, PROTEIN CASC5 | Authors: | Krenn, V, Wehenkel, A, Li, X, Santaguida, S, Musacchio, A. | Deposit date: | 2011-09-15 | Release date: | 2012-02-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Analysis Reveals Features of the Spindle Checkpoint Kinase Bub1-Kinetochore Subunit Knl1 Interaction. J.Cell Biol., 196, 2012
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7XFG
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![BU of 7xfg by Molmil](/molmil-images/mine/7xfg) | |
6WHJ
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![BU of 6whj by Molmil](/molmil-images/mine/6whj) | |
7XEZ
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![BU of 7xez by Molmil](/molmil-images/mine/7xez) | |
6XPU
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![BU of 6xpu by Molmil](/molmil-images/mine/6xpu) | |
6QIX
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![BU of 6qix by Molmil](/molmil-images/mine/6qix) | The crystal structure of Trichuris muris p43 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Levy, C.W. | Deposit date: | 2019-01-21 | Release date: | 2019-06-12 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function. Nat Commun, 10, 2019
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5A9I
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![BU of 5a9i by Molmil](/molmil-images/mine/5a9i) | Crystal structure of the extracellular domain of PepT2 | Descriptor: | CITRIC ACID, GLYCEROL, SOLUTE CARRIER FAMILY 15 MEMBER 2 | Authors: | Beale, J.H, Newstead, S. | Deposit date: | 2015-07-21 | Release date: | 2015-09-09 | Last modified: | 2019-10-09 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | Crystal Structures of the Extracellular Domain from Pept1 and Pept2 Provide Novel Insights Into Mammalian Peptide Transport Structure, 23, 2015
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7PWF
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![BU of 7pwf by Molmil](/molmil-images/mine/7pwf) | Cryo-EM structure of small subunit of Giardia lamblia ribosome at 2.9 A resolution | Descriptor: | 40S ribosomal protein S21, 40S ribosomal protein S25, 40S ribosomal protein S26, ... | Authors: | Hiregange, D.G, Rivalta, A, Bose, T, Breiner-Goldstein, E, Samiya, S, Cimicata, G, Kulakova, L, Zimmerman, E, Bashan, A, Herzberg, O, Yonath, A. | Deposit date: | 2021-10-06 | Release date: | 2022-05-25 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia. Nucleic Acids Res., 50, 2022
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7W6P
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![BU of 7w6p by Molmil](/molmil-images/mine/7w6p) | Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist | Descriptor: | Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | Deposit date: | 2021-12-02 | Release date: | 2022-09-28 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
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7W7E
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![BU of 7w7e by Molmil](/molmil-images/mine/7w7e) | Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist | Descriptor: | 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. | Deposit date: | 2021-12-04 | Release date: | 2022-09-28 | Last modified: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
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7C38
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![BU of 7c38 by Molmil](/molmil-images/mine/7c38) | Crystal structure of AofleA from Arthrobotrys oligospora in complex with L-fucose | Descriptor: | AofleA, GLYCEROL, alpha-L-fucopyranose, ... | Authors: | Liu, M, Cheng, X, Wang, J, Zhang, M, Wang, M. | Deposit date: | 2020-05-11 | Release date: | 2020-07-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural insights into the fungi-nematodes interaction mediated by fucose-specific lectin AofleA from Arthrobotrys oligospora. Int.J.Biol.Macromol., 164, 2020
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8HQY
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![BU of 8hqy by Molmil](/molmil-images/mine/8hqy) | Cryo-EM structure of SSX1 bound to the H2AK119Ub nucleosome at a resolution of 3.05 angstrom | Descriptor: | DNA (136-MER), DNA (137-MER), Histone H2A type 1-B/E, ... | Authors: | Zebin, T, Ai, H.S, Ziyu, X, GuoChao, C, Man, P, Liu, L. | Deposit date: | 2022-12-14 | Release date: | 2023-09-27 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes. Nat.Struct.Mol.Biol., 31, 2024
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6ZDE
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![BU of 6zde by Molmil](/molmil-images/mine/6zde) | 17beta-hydroxysteroid dehydrogenase type 14 variant S205 in complex with pentafluorophenol | Descriptor: | 17-beta-hydroxysteroid dehydrogenase 14, 2,3,4,5,6-pentakis(fluoranyl)phenol, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Badran, M.J, Heine, A, Klebe, G. | Deposit date: | 2020-06-14 | Release date: | 2021-01-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | 17beta-hydroxysteroid dehydrogenase type 14 variant S205 in complex with pentafluorophenol To Be Published
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