1SES
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3KFL
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![BU of 3kfl by Molmil](/molmil-images/mine/3kfl) | Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ... | Authors: | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | Deposit date: | 2009-10-27 | Release date: | 2010-10-27 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie, 93, 2011
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2HL1
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![BU of 2hl1 by Molmil](/molmil-images/mine/2hl1) | Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with seryl-3'-aminoadenosine | Descriptor: | SERINE-3'-AMINOADENOSINE, Threonyl-tRNA synthetase | Authors: | Hussain, T, Kruparani, S.P, Pal, B, Sankaranarayanan, R. | Deposit date: | 2006-07-06 | Release date: | 2006-08-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea Embo J., 25, 2006
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5V49
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2HL0
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![BU of 2hl0 by Molmil](/molmil-images/mine/2hl0) | Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with seryl-3'-aminoadenosine | Descriptor: | SERINE-3'-AMINOADENOSINE, Threonyl-tRNA synthetase | Authors: | Hussain, T, Kruparani, S.P, Pal, B, Sankaranarayanan, R. | Deposit date: | 2006-07-06 | Release date: | 2006-08-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea Embo J., 25, 2006
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2HL2
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![BU of 2hl2 by Molmil](/molmil-images/mine/2hl2) | Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus abyssi in complex with an analog of seryladenylate | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Threonyl-tRNA synthetase | Authors: | Hussain, T, Kruparani, S.P, Pal, B, Sankaranarayanan, R. | Deposit date: | 2006-07-06 | Release date: | 2006-08-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Post-transfer editing mechanism of a D-aminoacyl-tRNA deacylase-like domain in threonyl-tRNA synthetase from archaea Embo J., 25, 2006
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5USF
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5XIF
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![BU of 5xif by Molmil](/molmil-images/mine/5xif) | Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Toxoplasma gondii | Descriptor: | CHLORIDE ION, Prolyl-tRNA synthetase (ProRS) | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
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5XIQ
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![BU of 5xiq by Molmil](/molmil-images/mine/5xiq) | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Halofuginone | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
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5XII
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![BU of 5xii by Molmil](/molmil-images/mine/5xii) | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6 | Descriptor: | 1,2-ETHANEDIOL, 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
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5XIL
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![BU of 5xil by Molmil](/molmil-images/mine/5xil) | Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS) | Descriptor: | ACETATE ION, MAGNESIUM ION, Putative prolyl-tRNA synthetase, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
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5XIG
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![BU of 5xig by Molmil](/molmil-images/mine/5xig) | Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Inhibitor 1 | Descriptor: | 3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Jain, V, Manickam, Y, Sharma, A. | Deposit date: | 2017-04-26 | Release date: | 2018-03-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis Structure, 25, 2017
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3NEA
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![BU of 3nea by Molmil](/molmil-images/mine/3nea) | Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Peptidyl-tRNA hydrolase | Authors: | Lam, R, McGrath, T.E, Romanov, V, Gothe, S.A, Peddi, S.R, Razumova, E, Lipman, R.S, Branstrom, A.A, Chirgadze, N.Y. | Deposit date: | 2010-06-08 | Release date: | 2011-06-15 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of Francisella tularensis peptidyl-tRNA hydrolase. Acta Crystallogr.,Sect.F, 67, 2011
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2HKZ
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3P0I
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3P0H
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![BU of 3p0h by Molmil](/molmil-images/mine/3p0h) | Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form | Descriptor: | 3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase | Authors: | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | Deposit date: | 2010-09-28 | Release date: | 2011-03-23 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011
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3P0J
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3A31
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![BU of 3a31 by Molmil](/molmil-images/mine/3a31) | Crystal structure of putative threonyl-tRNA synthetase ThrRS-1 from Aeropyrum pernix (selenomethionine derivative) | Descriptor: | Probable threonyl-tRNA synthetase 1, SULFATE ION, ZINC ION | Authors: | Shimizu, S, Juan, E.C.M, Miyashita, Y, Sato, Y, Hoque, M.M, Suzuki, K, Yogiashi, M, Tsunoda, M, Dock-Bregeon, A.-C, Moras, D, Sekiguchi, T, Takenaka, A. | Deposit date: | 2009-06-07 | Release date: | 2009-10-27 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain J.Mol.Biol., 394, 2009
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3A32
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![BU of 3a32 by Molmil](/molmil-images/mine/3a32) | Crystal structure of putative threonyl-tRNA synthetase ThrRS-1 from Aeropyrum pernix | Descriptor: | Probable threonyl-tRNA synthetase 1, SULFATE ION, ZINC ION | Authors: | Shimizu, S, Juan, E.C.M, Miyashita, Y, Sato, Y, Hoque, M.M, Suzuki, K, Yogiashi, M, Tsunoda, M, Dock-Bregeon, A.-C, Moras, D, Sekiguchi, T, Takenaka, A. | Deposit date: | 2009-06-07 | Release date: | 2009-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain J.Mol.Biol., 394, 2009
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2ZCE
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![BU of 2zce by Molmil](/molmil-images/mine/2zce) | Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase in complex with pyrrolysine and an ATP analogue | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PYRROLYSINE, ... | Authors: | Yanagisawa, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-11-08 | Release date: | 2008-04-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystallographic Studies on Multiple Conformational States of Active-site Loops in Pyrrolysyl-tRNA Synthetase J.Mol.Biol., 378, 2008
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1TKY
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![BU of 1tky by Molmil](/molmil-images/mine/1tky) | Crystal structure of the editing domain of threonyl-tRNA synthetase complexed with seryl-3'-aminoadenosine | Descriptor: | SERINE-3'-AMINOADENOSINE, Threonyl-tRNA synthetase | Authors: | Dock-Bregeon, A.C, Rees, B, Torres-Larios, A, Bey, G, Caillet, J, Moras, D. | Deposit date: | 2004-06-09 | Release date: | 2004-11-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Achieving Error-Free Translation; The Mechanism of Proofreading of Threonyl-tRNA Synthetase at Atomic Resolution. Mol.Cell, 16, 2004
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3QTC
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![BU of 3qtc by Molmil](/molmil-images/mine/3qtc) | Crystal structure of the catalytic domain of MmOmeRS, an O-methyl tyrosyl-tRNA synthetase evolved from Methanosarcina mazei PylRS, complexed with O-methyl tyrosine and AMP-PNP | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, O-methyl-L-tyrosine, ... | Authors: | Dellas, N, Takimoto, J.K, Noel, J.P, Wang, L. | Deposit date: | 2011-02-22 | Release date: | 2011-05-25 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids. Acs Chem.Biol., 6, 2011
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1TKE
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![BU of 1tke by Molmil](/molmil-images/mine/1tke) | Crystal structure of the editing domain of threonyl-tRNA synthetase complexed with serine | Descriptor: | SERINE, Threonyl-tRNA synthetase | Authors: | Dock-Bregeon, A.C, Rees, B, Torres-Larios, A, Bey, G, Caillet, J, Moras, D. | Deposit date: | 2004-06-08 | Release date: | 2004-11-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Achieving Error-Free Translation; The Mechanism of Proofreading of Threonyl-tRNA Synthetase at Atomic Resolution. Mol.Cell, 16, 2004
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3BJU
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![BU of 3bju by Molmil](/molmil-images/mine/3bju) | Crystal Structure of tetrameric form of human lysyl-tRNA synthetase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, LYSINE, ... | Authors: | Guo, M, Yang, X.L, Schimmel, P. | Deposit date: | 2007-12-04 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation Proc.Natl.Acad.Sci.Usa, 105, 2008
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1WLE
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![BU of 1wle by Molmil](/molmil-images/mine/1wle) | Crystal Structure of mammalian mitochondrial seryl-tRNA synthetase complexed with seryl-adenylate | Descriptor: | SERYL ADENYLATE, Seryl-tRNA synthetase | Authors: | Chimnaronk, S, Jeppesen, M.G, Suzuki, T, Nyborg, J, Watanabe, K. | Deposit date: | 2004-06-25 | Release date: | 2005-09-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria Embo J., 24, 2005
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