PDB: 92137 resultsInfo pagesStatus searchChemie searchBIRD

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3SY2	Crystal structure of the Salmonella E3 ubiquitin ligase SopA in complex with the human E2 UbcH7 Descriptor: E3 ubiquitin-protein ligase SopA, SULFATE ION, Ubiquitin-conjugating enzyme E2 L3 Authors: Diao, J, Lin, D.Y, Chen, J. Deposit date: 2011-07-15 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.27 Å) Cite: Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions. Proc.Natl.Acad.Sci.USA, 109, 2012
6N67	Crystal structure of the ligase domain of fungal tRNA ligase Trl1 Descriptor: CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, GLYCEROL, ... Authors: Peschek, J, Walter, P. Deposit date: 2018-11-26 Release date: 2019-07-03 Last modified: 2019-07-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. Elife, 8, 2019
7EV3	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Y-10 and ATP Descriptor: (5S)-5-[(1R)-1-(4-fluoranyl-1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Xu, M, Chen, S. Deposit date: 2021-05-20 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
7EV2	Crystal structure of Mycobacterium tuberculosis tryptophanyl-tRNA synthetase complexed with Y-11 and ATP Descriptor: (5S)-5-[(1R)-1-(4-chloranyl-1H-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Xu, M, Chen, S. Deposit date: 2021-05-20 Release date: 2022-02-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. Acs Chem.Biol., 17, 2022
8ART	ABC transporter binding protein MalE from Streptomyces scabiei in complex with maltose Descriptor: Putative secreted maltose-binding protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose Authors: Jadot, C, Kerff, F, Rigali, S. Deposit date: 2022-08-17 Release date: 2023-08-30 Method: X-RAY DIFFRACTION (3.17 Å) Cite: Structure of ligand binding protein of ABC transporter from Streptomyces scabiei at 3.17 Angstroms resolution. To Be Published
4KBL	Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism Descriptor: E3 ubiquitin-protein ligase ARIH1, ZINC ION Authors: Duda, D.M, Olszewski, J.L, Schulman, B.A. Deposit date: 2013-04-23 Release date: 2013-05-29 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
4KC9	Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism Descriptor: E3 ubiquitin-protein ligase ARIH1, ZINC ION Authors: Duda, D.M, Olszewski, J.L, Schulman, B.A. Deposit date: 2013-04-24 Release date: 2013-05-29 Last modified: 2013-07-03 Method: X-RAY DIFFRACTION (3.603 Å) Cite: Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013
2OWO	Last Stop on the Road to Repair: Structure of E.coli DNA Ligase Bound to Nicked DNA-Adenylate Descriptor: 26-MER, 5'-D(*AP*CP*AP*AP*TP*TP*GP*CP*GP*AP*CP*(OMC)P*C)-3', 5'-D(*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*G)-3', ... Authors: Shuman, S, Nandakumar, J, Nair, P.A. Deposit date: 2007-02-16 Release date: 2007-05-15 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Last Stop on the Road to Repair: Structure of E. coli DNA Ligase Bound to Nicked DNA-Adenylate. Mol.Cell, 26, 2007
3PC7	X-ray crystal structure of the DNA ligase III-alpha BRCT domain. Descriptor: DNA ligase 3 Authors: Cuneo, M.J, Krahn, J.M, London, R.E. Deposit date: 2010-10-21 Release date: 2011-06-15 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: The structural basis for partitioning of the XRCC1/DNA ligase III-{alpha} BRCT-mediated dimer complexes. Nucleic Acids Res., 39, 2011
5WZZ	The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation Descriptor: Axin-1, E3 ubiquitin-protein ligase SIAH1, ZINC ION Authors: Ji, L, Jiang, B, Jiang, X, Charlat, O, Chen, A, Mickanin, C, Bauer, A, Xu, W, Yan, X.-X, Cong, F. Deposit date: 2017-01-19 Release date: 2017-08-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.103 Å) Cite: The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation Genes Dev., 31, 2017
5TT6	T4 RNA Ligase 1 (K99M) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, T4 RNA ligase 1 Authors: Goldgur, Y, Unciuleac, M.-C, Shuman, S.H. Deposit date: 2016-11-01 Release date: 2017-03-08 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.187 Å) Cite: Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4DQ2	Structure of staphylococcus aureus biotin protein ligase in complex with biotinol-5'-amp Descriptor: ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE, Biotin-[acetyl-CoA-carboxylase] ligase Authors: Wilce, M, Yap, M, Pendini, N, Soares de Costa, T, Polyak, S, Tieu, W, Booker, G, Wallace, J. Deposit date: 2012-02-14 Release date: 2012-04-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Selective inhibition of biotin protein ligase from Staphylococcus aureus. J.Biol.Chem., 287, 2012
8ADF	X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ39 Descriptor: (2R)-3-(4-bromophenyl)-2-(3-hydroxyphenyl)-4-oxidanyl-2H-furan-5-one, Peroxisome proliferator-activated receptor gamma Authors: Capelli, D, Montanari, R, Pochetti, G, Meneghetti, F, Villa, S. Deposit date: 2022-07-08 Release date: 2023-04-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13, 2023
5WR2	Thermolysin, SFX liganded form with oil-based carrier Descriptor: CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ... Authors: Kunishima, N, Naitow, H, Matsuura, Y. Deposit date: 2016-11-29 Release date: 2017-08-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
5WR4	Thermolysin, SFX unliganded form with oil-based carrier Descriptor: CALCIUM ION, Thermolysin, ZINC ION Authors: Kunishima, N, Naitow, H, Matsuura, Y. Deposit date: 2016-11-29 Release date: 2017-08-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
5WR5	Thermolysin, liganded form with cryo condition 1 Descriptor: CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, TETRAETHYLENE GLYCOL, ... Authors: Kunishima, N, Naitow, H, Matsuura, Y. Deposit date: 2016-11-29 Release date: 2017-08-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017
7M4O	Crystal structure of phosphorylated RBR E3 ligase RNF216 in complex with K63-linked di-ubiquitin Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, E3 ubiquitin-protein ligase RNF216, GLYCEROL, ... Authors: Cotton, T.R, Lechtenberg, B.C. Deposit date: 2021-03-21 Release date: 2022-01-05 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.21 Å) Cite: Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216. Mol.Cell, 82, 2022
7M4M	Crystal structure of RBR E3 ligase RNF216 with ubiquitin Descriptor: E3 ubiquitin-protein ligase RNF216, GLYCEROL, Ubiquitin, ... Authors: Cotton, T.R, Lechtenberg, B.C. Deposit date: 2021-03-21 Release date: 2022-01-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216. Mol.Cell, 82, 2022
7M4N	Crystal structure of RBR E3 ligase RNF216 in complex with K63-linked di-ubiquitin Descriptor: E3 ubiquitin-protein ligase RNF216, GLYCEROL, SULFATE ION, ... Authors: Cotton, T.R, Lechtenberg, B.C. Deposit date: 2021-03-21 Release date: 2022-01-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216. Mol.Cell, 82, 2022
3K3P	Crystal Structure of the Apo Form of D-Alanine:D-Alanine Ligase (DDl) from Streptococcus mutans Descriptor: D-alanine--D-alanine ligase Authors: Lu, Y. Deposit date: 2009-10-03 Release date: 2010-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans. Protein Pept.Lett., 17, 2010
4XM8	Anthrax toxin lethal factor with ligand-induced binding pocket Descriptor: Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION Authors: Maize, K.M, Finzel, B.C. Deposit date: 2015-01-14 Release date: 2015-11-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
4XM7	Anthrax toxin lethal factor with ligand-induced binding pocket Descriptor: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ... Authors: Maize, K.M, Finzel, B.C. Deposit date: 2015-01-14 Release date: 2015-11-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor. Febs Lett., 589, 2015
4PP5	Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 5-methyl UAB30 and the coactivator peptide GRIP-1 Descriptor: (2E,4E,6Z,8E)-3,7-dimethyl-8-(5-methyl-3,4-dihydronaphthalen-1(2H)-ylidene)octa-2,4,6-trienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha Authors: Xia, G, Smith, C.D, Muccio, D.D. Deposit date: 2014-02-26 Release date: 2014-06-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J.Med.Chem., 57, 2014
8C0C	X-ray crystal structure of PPAR gamma ligand binding domain in complex with CZ46 Descriptor: (2~{R})-2-[4-(naphthalen-1-ylmethoxy)phenyl]-4-oxidanyl-3-phenyl-2~{H}-furan-5-one, Peroxisome proliferator-activated receptor gamma Authors: Capelli, D, Montanari, R, Pochetti, G, Villa, S, Meneghetti, F. Deposit date: 2022-12-16 Release date: 2023-04-26 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Biological Screening and Crystallographic Studies of Hydroxy gamma-Lactone Derivatives to Investigate PPAR gamma Phosphorylation Inhibition. Biomolecules, 13, 2023
5WR6	Thermolysin, liganded form with cryo condition 2 Descriptor: CALCIUM ION, N-[(benzyloxy)carbonyl]-L-aspartic acid, Thermolysin, ... Authors: Kunishima, N, Naitow, H, Matsuura, Y. Deposit date: 2016-11-29 Release date: 2017-08-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Protein-ligand complex structure from serial femtosecond crystallography using soaked thermolysin microcrystals and comparison with structures from synchrotron radiation Acta Crystallogr D Struct Biol, 73, 2017

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