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4LBU	tRNA guanine transglycosylase (TGT) in complex with Furanoside-Based lin-Benzoguanine 2 Descriptor: CHLORIDE ION, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Ehrmann, F.R, Heine, A, Klebe, G. Deposit date: 2013-06-21 Release date: 2014-12-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.17 Å) Cite: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT). Chemistry, 21, 2015
4LEQ	tRNA guanine transglycosylase (TGT) in complex with Furanoside-Based lin-Benzoguanine 1 Descriptor: CHLORIDE ION, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Ehrmann, F.R, Heine, A, Klebe, G. Deposit date: 2013-06-26 Release date: 2014-12-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.405 Å) Cite: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT). Chemistry, 21, 2015
3HXX	Crystal Structure of catalytic fragment of E. coli AlaRS in complex with AMPPCP Descriptor: Alanyl-tRNA synthetase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER Authors: Guo, M, Yang, X.-L, Schimmel, P. Deposit date: 2009-06-22 Release date: 2009-12-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature, 462, 2009
4KWO	tRNA guanine transglycosylase (TGT) in complex with Furanoside-Based lin-Benzoguanine 3 Descriptor: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION, ... Authors: Ehrmann, F.R, Heine, A, Klebe, G. Deposit date: 2013-05-24 Release date: 2014-12-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Replacement of Water Molecules in a Phosphate Binding Site by Furanoside-Appended lin-Benzoguanine Ligands of tRNA-Guanine Transglycosylase (TGT). Chemistry, 21, 2015
2Z1V	tRNA guanine transglycosylase E235Q mutant apo structure, pH 8.5 Descriptor: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION Authors: Tidten, N, Stengl, B, Heine, A, Garcia, G.A, Klebe, G, Reuter, K. Deposit date: 2007-05-15 Release date: 2007-11-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies J.Mol.Biol., 374, 2007
2Z1W	tRNA guanine transglycosylase TGT E235Q mutant in complex with BDI (2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE) Descriptor: 2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Tidten, N, Stengl, B, Heine, A, Garcia, G.A, Klebe, G, Reuter, K. Deposit date: 2007-05-16 Release date: 2007-11-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies J.Mol.Biol., 374, 2007
1RI5	Structure and mechanism of mRNA cap (guanine N-7) methyltransferase Descriptor: mRNA CAPPING ENZYME Authors: Fabrega, C, Hausmann, S, Shen, V, Shuman, S, Lima, C.D, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) Deposit date: 2003-11-16 Release date: 2004-02-03 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure and mechanism of mRNA cap (Guanine-n7) methyltransferase Mol.Cell, 13, 2004
4L56	tRNA guanine transglycosylase H333D mutant apo structure Descriptor: GLYCEROL, Queuine tRNA-ribosyltransferase, ZINC ION Authors: Nguyen, T.X.P, Heine, A, Klebe, G. Deposit date: 2013-06-10 Release date: 2014-12-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme Tgt. Acs Chem.Biol., 10, 2015
3B0P	tRNA-dihydrouridine synthase from Thermus thermophilus Descriptor: FLAVIN MONONUCLEOTIDE, tRNA-dihydrouridine synthase Authors: Yu, F, Tanaka, Y, Yamashita, K, Nakamura, A, Yao, M, Tanaka, I. Deposit date: 2011-06-12 Release date: 2011-12-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular basis of dihydrouridine formation on tRNA Proc.Natl.Acad.Sci.USA, 108, 2011
2Z1X	tRNA guanine transglycosylase E235Q mutant in complex with preQ1 Descriptor: 7-DEAZA-7-AMINOMETHYL-GUANINE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Tidten, N, Stengl, B, Heine, A, Garcia, G.A, Klebe, G, Reuter, K. Deposit date: 2007-05-16 Release date: 2007-11-06 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Glutamate versus Glutamine Exchange Swaps Substrate Selectivity in tRNA-Guanine Transglycosylase: Insight into the Regulation of Substrate Selectivity by Kinetic and Crystallographic Studies J.Mol.Biol., 374, 2007
3PZC	Crystal structure of class II aaRS homologue (Bll0957) complexed with Coenzyme A Descriptor: ACETATE ION, Amino acid--[acyl-carrier-protein] ligase 1, COENZYME A, ... Authors: Weygand-Durasevic, I, Luic, M, Mocibob, M, Ivic, N, Subasic, D. Deposit date: 2010-12-14 Release date: 2011-10-19 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Substrate Recognition by Novel Family of Amino Acid:[Carrier Protein] Ligases Croatica Chemica Acta, 84, 2011
2ZT8	Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog Descriptor: Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate Authors: Guo, R.T, Yang, X.L, Schimmel, P. Deposit date: 2008-09-19 Release date: 2009-08-25 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis To be Published
1N87	Solution structure of the U-box of Prp19 Descriptor: Pre-mRNA splicing factor PRP19 Authors: Chazin, W.J, Ohi, M.D, Vander Kooi, C.W. Deposit date: 2002-11-19 Release date: 2003-04-15 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structural insights into the U-box, a domain associated with multi-ubiquitination Nat.Struct.Biol., 10, 2003
3UVI	tRNA-guanine transglycosylase C158S C281S W326E E339Q mutant Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... Authors: Jakobi, S, Heine, A, Klebe, G. Deposit date: 2011-11-30 Release date: 2012-11-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme. Proteins, 82, 2014
2N6T	NMR Assignment and NMR Structure of CssA3 (top stem) of CssA thermometer Descriptor: RNA (42-MER) Authors: Barnwal, R, Godin, K, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-08-28 Release date: 2016-08-03 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis. Nucleic Acids Res., 44, 2016
2N6X	NMR Assignment and structure of CssA5 (middle region) of CssA thermometer from Neisseria meningitidis Descriptor: RNA (43-MER) Authors: Barnwal, R, Godin, K, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-08-31 Release date: 2016-08-03 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis. Nucleic Acids Res., 44, 2016
2N6W	NMR Assignment and structure of CssA Thermometer from Neisseria meningitidis Descriptor: RNA (68-MER) Authors: Barnwal, R, Godin, K, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-08-28 Release date: 2016-08-03 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis. Nucleic Acids Res., 44, 2016
6Z3S	Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with O-Acetylserine Descriptor: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase Authors: Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A. Deposit date: 2020-05-21 Release date: 2021-06-02 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3.048 Å) Cite: Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii . Comput Struct Biotechnol J, 19, 2021
6ZS7	Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with L-cysteine Descriptor: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase Authors: Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A. Deposit date: 2020-07-15 Release date: 2021-07-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii . Comput Struct Biotechnol J, 19, 2021
2M18	Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution Descriptor: RNA (5'-R(*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') Authors: Martadinata, H, Phan, A.T. Deposit date: 2012-11-20 Release date: 2013-04-17 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure of Human Telomeric RNA (TERRA): Stacking of Two G-Quadruplex Blocks in K(+) Solution Biochemistry, 52, 2013
7EAG	Crystal structure of the RAGATH-18 k-turn Descriptor: RNA (5'-R(*GP*UP*CP*UP*AP*UP*GP*AP*AP*GP*GP*CP*UP*GP*GP*AP*GP*AP*C)-3') Authors: Huang, L, Lilley, D.M.J. Deposit date: 2021-03-07 Release date: 2021-06-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure and folding of four putative kink turns identified in structured RNA species in a test of structural prediction rules. Nucleic Acids Res., 49, 2021
2N6S	Structure of CssA4 (bottom stem) of CssA thermometer Descriptor: RNA (36-MER) Authors: Barnwal, R, Godin, K, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2015-08-28 Release date: 2016-08-03 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis. Nucleic Acids Res., 44, 2016
4DY1	tRNA-guanine transglycosylase F92C C158S C281S mutant Descriptor: CHLORIDE ION, Queuine tRNA-ribosyltransferase, ZINC ION Authors: Jakobi, S, Heine, A, Klebe, G. Deposit date: 2012-02-28 Release date: 2013-03-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.045 Å) Cite: What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme Tgt. Acs Chem.Biol., 10, 2015
1Y5V	tRNA-Guanine Transglycosylase (TGT) in complex with 6-Amino-4-(2-phenylethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one Descriptor: 6-AMINO-4-(2-PHENYLETHYL)-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Stengl, B, Meyer, E.A, Heine, A, Brenk, R, Diederich, F, Klebe, G. Deposit date: 2004-12-03 Release date: 2005-12-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding J.Mol.Biol., 370, 2007
1Y5W	tRNA-guanine Transglycosylase (TGT) in complex with 6-Amino-4-[2-(4-methylphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one Descriptor: 6-AMINO-4-[2-(4-METHYLPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Stengl, B, Meyer, E.A, Heine, A, Brenk, R, Diederich, F, Klebe, G. Deposit date: 2004-12-03 Release date: 2005-12-13 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding J.Mol.Biol., 370, 2007

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