8K7K
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![BU of 8k7k by Molmil](/molmil-images/mine/8k7k) | Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3S,4R,5R)-2,5-bis(hydroxymethyl)-1-methylpyrrolidine-3,4-diol | Descriptor: | (2~{R},3~{S},4~{R},5~{R})-2,5-bis(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | Deposit date: | 2023-07-26 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8K7L
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![BU of 8k7l by Molmil](/molmil-images/mine/8k7l) | Crystal structure of human lysosomal alpha-galactosidase A in complex with (2R,3R,4S,5R)-2-(aminomethyl)-5-(hydroxymethyl)-1-methylpyrrolidine-3,4-diol | Descriptor: | (2~{R},3~{R},4~{S},5~{R})-2-(aminomethyl)-5-(hydroxymethyl)-1-methyl-pyrrolidine-3,4-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, H.Y, Huang, K.F, Ko, T.P, Cheng, W.C. | Deposit date: | 2023-07-26 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Mechanistic Insights into Dibasic Iminosugars as pH-Selective Pharmacological Chaperones to Stabilize Human alpha-Galactosidase. Jacs Au, 4, 2024
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8K8E
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![BU of 8k8e by Molmil](/molmil-images/mine/8k8e) | Human gamma-secretase in complex with a substrate mimetic | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Shi, Y.G, Zhou, R, Wolfe, M.S. | Deposit date: | 2023-07-29 | Release date: | 2024-01-31 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Familial Alzheimer mutations stabilize synaptotoxic gamma-secretase-substrate complexes. Cell Rep, 43, 2024
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8KA8
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![BU of 8ka8 by Molmil](/molmil-images/mine/8ka8) | Cryo-EM structure of SARS-CoV-2 Delta RBD in complex with golden hamster ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | Authors: | Niu, S, Zhao, Z.N, Chai, Y, Gao, G.F. | Deposit date: | 2023-08-02 | Release date: | 2024-01-31 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs. J.Virol., 98, 2024
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8KC2
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![BU of 8kc2 by Molmil](/molmil-images/mine/8kc2) | Cryo-EM structure of SARS-CoV-2 BA.3 RBD in complex with golden hamster ACE2 (local refinement) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, ... | Authors: | Niu, S, Zhao, Z.N, Chai, Y, Gao, G.F. | Deposit date: | 2023-08-05 | Release date: | 2024-01-31 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural basis and analysis of hamster ACE2 binding to different SARS-CoV-2 spike RBDs. J.Virol., 98, 2024
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8KCO
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![BU of 8kco by Molmil](/molmil-images/mine/8kco) | Cryo-EM structure of human gamma-secretase in complex with RO4929097 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2023-08-08 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560 To Be Published
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8KCP
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![BU of 8kcp by Molmil](/molmil-images/mine/8kcp) | Cryo-EM structure of human gamma-secretase in complex with Crenigacestat | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2023-08-08 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCS
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![BU of 8kcs by Molmil](/molmil-images/mine/8kcs) | Cryo-EM structure of human gamma-secretase in complex with BMS906024 | Descriptor: | (2S,3R)-N'-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-2,3-bis[3,3,3-tris(fluoranyl)propyl]butanediamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2023-08-08 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCT
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![BU of 8kct by Molmil](/molmil-images/mine/8kct) | Cryo-EM structure of human gamma-secretase in complex with Nirogacestat | Descriptor: | (2S)-2-[[(2S)-6,8-bis(fluoranyl)-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methyl-propan-2-yl]imidazol-4-yl]pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2023-08-08 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCU
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![BU of 8kcu by Molmil](/molmil-images/mine/8kcu) | Cryo-EM structure of human gamma-secretase in complex with MK-0752 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | Deposit date: | 2023-08-08 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural Basis of gamma-secretase inhibition by anti-cancer clinical drugs To Be Published
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8KCW
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![BU of 8kcw by Molmil](/molmil-images/mine/8kcw) | Cryo-EM structure of human SIDT1 bound to cholesterol | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SID1 transmembrane family member 1, ... | Authors: | Hirano, Y, Ohto, U, Shimizu, T. | Deposit date: | 2023-08-08 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity. Commun Biol, 7, 2024
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8KCX
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![BU of 8kcx by Molmil](/molmil-images/mine/8kcx) | Cryo-EM structure of human SIDT1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SID1 transmembrane family member 1, ZINC ION, ... | Authors: | Hirano, Y, Ohto, U, Shimizu, T. | Deposit date: | 2023-08-08 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity. Commun Biol, 7, 2024
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8KHC
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![BU of 8khc by Molmil](/molmil-images/mine/8khc) | SARS-CoV-2 Omicron spike in complex with 5817 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 5817 Fab, ... | Authors: | Cao, L, Wang, X. | Deposit date: | 2023-08-21 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain. Cell Rep, 43, 2024
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8OE0
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![BU of 8oe0 by Molmil](/molmil-images/mine/8oe0) | Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | Authors: | Felix, J, Bloch, Y, Savvides, S.N. | Deposit date: | 2023-03-10 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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8OE4
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![BU of 8oe4 by Molmil](/molmil-images/mine/8oe4) | Cryo-EM structure of a pre-dimerized human IL-23 complete extracellular signaling complex. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, ... | Authors: | Bloch, Y, Felix, J, Savvides, S.N. | Deposit date: | 2023-03-10 | Release date: | 2024-02-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
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8OG4
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![BU of 8og4 by Molmil](/molmil-images/mine/8og4) | Exostosin-like 3 UDP complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-like 3, MANGANESE (II) ION, ... | Authors: | Sammon, D, Hohenester, E. | Deposit date: | 2023-03-18 | Release date: | 2023-07-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular mechanism of decision-making in glycosaminoglycan biosynthesis. Nat Commun, 14, 2023
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8OGI
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![BU of 8ogi by Molmil](/molmil-images/mine/8ogi) | Structure of native human eosinophil peroxidase | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Pfanzagl, V, Obinger, C. | Deposit date: | 2023-03-20 | Release date: | 2024-01-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.547 Å) | Cite: | Posttranslational modification and heme cavity architecture of human eosinophil peroxidase-insights from first crystal structure and biochemical characterization. J.Biol.Chem., 299, 2023
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8OHN
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![BU of 8ohn by Molmil](/molmil-images/mine/8ohn) | Human Coronavirus HKU1 spike glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Pronker, M.F, Hurdiss, D.L. | Deposit date: | 2023-03-21 | Release date: | 2023-08-02 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Sialoglycan binding triggers spike opening in a human coronavirus. Nature, 624, 2023
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8OK8
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![BU of 8ok8 by Molmil](/molmil-images/mine/8ok8) | Variant Surface Glycoprotein VSG615 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Variant surface glycoprotein 615, ... | Authors: | Zeelen, J.P, Stebbins, C.E, Chandra, M. | Deposit date: | 2023-03-27 | Release date: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | A structural classification of the variant surface glycoproteins of the African trypanosomey. Plos Negl Trop Dis, 17, 2023
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8ON7
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![BU of 8on7 by Molmil](/molmil-images/mine/8on7) | FMRFa-bound Malacoceros FaNaC1 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FMRFamide, ... | Authors: | Kalienkova, V, Dandamudi, M, Paulino, C, Lynagh, T. | Deposit date: | 2023-04-01 | Release date: | 2024-02-14 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural basis for excitatory neuropeptide signaling. Nat.Struct.Mol.Biol., 31, 2024
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8ON8
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![BU of 8on8 by Molmil](/molmil-images/mine/8on8) | Apo Malacoceros FaNaC1 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FMRFamide-gated sodium channel 1 | Authors: | Kalienkova, V, Dandamudi, M, Paulino, C, Lynagh, T. | Deposit date: | 2023-04-01 | Release date: | 2024-02-14 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural basis for excitatory neuropeptide signaling. Nat.Struct.Mol.Biol., 31, 2024
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8ON9
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![BU of 8on9 by Molmil](/molmil-images/mine/8on9) | ASSFVRIa-bound Malacoceros FaNaC1 in lipid nanodiscs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ASSFVRIamide, ... | Authors: | Kalienkova, V, Dandamudi, M, Paulino, C, Lynagh, T. | Deposit date: | 2023-04-01 | Release date: | 2024-02-14 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Structural basis for excitatory neuropeptide signaling. Nat.Struct.Mol.Biol., 31, 2024
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8ONE
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![BU of 8one by Molmil](/molmil-images/mine/8one) | Crystal Structure of full-length Human Lysyl Hydroxylase LH3 - Asp190Ser mutant - Cocrystal with Fe2+, Mn2+, UDP-Glucose | Descriptor: | 2-OXOGLUTARIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Mattoteia, D, De Marco, M, Pinnola, A, Faravelli, S, Scietti, L, Forneris, F. | Deposit date: | 2023-04-02 | Release date: | 2023-07-19 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of Regulatory Molecular "Hot Spots" for LH/PLOD Collagen Glycosyltransferase Activity. Int J Mol Sci, 24, 2023
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8OPM
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![BU of 8opm by Molmil](/molmil-images/mine/8opm) | Human Coronavirus HKU1 spike glycoprotein in complex with an alpha2,8-linked 9-O-acetylated disialoside (closed state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-O-acetyl-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid-(2-8)-N-acetyl-alpha-neuraminic acid, ... | Authors: | Pronker, M.F, Creutznacher, R, Hurdiss, D.L. | Deposit date: | 2023-04-07 | Release date: | 2023-08-02 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Sialoglycan binding triggers spike opening in a human coronavirus. Nature, 624, 2023
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8OPN
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![BU of 8opn by Molmil](/molmil-images/mine/8opn) | Human Coronavirus HKU1 spike glycoprotein in complex with an alpha2,8-linked 9-O-acetylated disialoside (1-up state) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 9-O-acetyl-5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid-(2-8)-N-acetyl-alpha-neuraminic acid, ... | Authors: | Pronker, M.F, Creutznacher, R, Hurdiss, D.L. | Deposit date: | 2023-04-07 | Release date: | 2023-08-02 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Sialoglycan binding triggers spike opening in a human coronavirus. Nature, 624, 2023
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