9EOE
 
 | | TF type tau filament from V337M mutant | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Qi, C, Scheres, S.H.W, Michel, G. | | Deposit date: | 2024-03-14 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W.
Biorxiv, 2024
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9EOC
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9EO9
 | | SF type tau filament from V337M mutant | | Descriptor: | Isoform Tau-F of Microtubule-associated protein tau | | Authors: | Qi, C, Scheres, S.H.W, Michel, G. | | Deposit date: | 2024-03-14 | | Release date: | 2024-07-10 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W.
Biorxiv, 2024
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9EO8
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9EO7
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9EO6
 | | SARS-CoV2 major protease in complex with a covalent inhibitor SLL11. | | Descriptor: | 3C-like proteinase nsp5, Inhibitor SLL11, POTASSIUM ION | | Authors: | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | | Deposit date: | 2024-03-14 | | Release date: | 2024-09-04 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries.
Antimicrob.Agents Chemother., 2024
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9EO5
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9EO4
 | | Outward-open structure of human dopamine transporter bound to cocaine | | Descriptor: | CHLORIDE ION, CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Nielsen, J.C, Salomon, K, Kalenderoglou, I.E, Bargmeyer, S, Pape, T, Shahsavar, A, Loland, C.J. | | Deposit date: | 2024-03-14 | | Release date: | 2024-07-03 | | Last modified: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structure of the human dopamine transporter in complex with cocaine.
Nature, 632, 2024
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9EO2
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9EO0
 | | Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 | | Descriptor: | Programmed cell death 1 ligand 1, SULFATE ION, ~{N}-[3-[3-[[5-[(2-hydroxyethylamino)methyl]pyridin-2-yl]carbonylamino]-2-methyl-phenyl]-2-methyl-phenyl]-5-[[3-(methylsulfonylamino)propylamino]methyl]pyridine-2-carboxamide | | Authors: | Plewka, J, Hec, A, Sitar, T, Holak, T. | | Deposit date: | 2024-03-14 | | Release date: | 2024-06-19 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Nonsymmetrically Substituted 1,1'-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction.
Acs Med.Chem.Lett., 15, 2024
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9ENZ
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9ENT
 | | SSX structure of Autotaxin in cryogenic conditions | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | | Authors: | Eymery, M.C, McCarthy, A.A, Foos, N, Basu, S. | | Deposit date: | 2024-03-13 | | Release date: | 2024-07-31 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | In situ serial crystallography facilitates 96-well plate structural analysis at low symmetry.
Iucrj, 11, 2024
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9ENQ
 | | HSV-1 DNA polymerase-processivity factor complex in exonuclease state active site with 1-bp DNA mismatch | | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (67-MER), ... | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2024-03-13 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.12 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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9ENP
 | | HSV-1 DNA polymerase-processivity factor complex in exonuclease state with 1-bp DNA mismatch | | Descriptor: | CALCIUM ION, DNA (46-MER), DNA (67-MER), ... | | Authors: | Gustavsson, E, Grunewald, K, Elias, P, Hallberg, B.M. | | Deposit date: | 2024-03-13 | | Release date: | 2024-05-29 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.12 Å) | | Cite: | Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM.
Nucleic Acids Res., 52, 2024
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9ENN
 | | L-amino acid oxidase 4 (HcLAAO4) from the fungus Hebeloma cylindrosporum in complex with N-epsilon-acetyl-L-lysine | | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, L-amino acid oxidase 4, N(6)-ACETYLLYSINE, ... | | Authors: | Gilzer, D, Koopmeiners, S, Fischer von Mollard, G, Niemann, H.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure and enzyme engineering of the broad substrate spectrum l-amino acid oxidase 4 from the fungus Hebeloma cylindrosporum.
Febs Lett., 2024
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9ENK
 | | L-amino acid oxidase 4 (HcLAAO4) from the fungus Hebeloma cylindrosporum in complex with L-phenylalanine | | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, L-amino acid oxidase 4, PHENYLALANINE, ... | | Authors: | Gilzer, D, Koopmeiners, S, Fischer von Mollard, G, Niemann, H.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure and enzyme engineering of the broad substrate spectrum l-amino acid oxidase 4 from the fungus Hebeloma cylindrosporum.
Febs Lett., 2024
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9ENJ
 | | L-amino acid oxidase 4 (HcLAAO4) from the fungus Hebeloma cylindrosporum in complex with L-glutamate | | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLUTAMIC ACID, L-amino acid oxidase 4, ... | | Authors: | Gilzer, D, Koopmeiners, S, Fischer von Mollard, G, Niemann, H.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure and enzyme engineering of the broad substrate spectrum l-amino acid oxidase 4 from the fungus Hebeloma cylindrosporum.
Febs Lett., 2024
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9ENI
 | | L-amino acid oxidase 4 (HcLAAO4) from the fungus Hebeloma cylindrosporum in complex with L-glutamine | | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLUTAMINE, L-amino acid oxidase 4, ... | | Authors: | Gilzer, D, Koopmeiners, S, Fischer von Mollard, G, Niemann, H.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure and enzyme engineering of the broad substrate spectrum l-amino acid oxidase 4 from the fungus Hebeloma cylindrosporum.
Febs Lett., 2024
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9ENH
 | | L-amino acid oxidase 4 (HcLAAO4) from the fungus Hebeloma cylindrosporum | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid oxidase 4, S-1,2-PROPANEDIOL, ... | | Authors: | Gilzer, D, Koopmeiners, S, Fischer von Mollard, G, Niemann, H.H. | | Deposit date: | 2024-03-13 | | Release date: | 2024-08-14 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure and enzyme engineering of the broad substrate spectrum l-amino acid oxidase 4 from the fungus Hebeloma cylindrosporum.
Febs Lett., 2024
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9ENF
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9ENE
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9END
 | | Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 3 | | Descriptor: | CHLORIDE ION, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Coquille, S, Roche, J, Girard, E, Madern, D. | | Deposit date: | 2024-03-12 | | Release date: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme.
To be published
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9ENC
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9ENB
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9EN6
 | | Crystal structure of RNA G2C4 repeats - native model pH 6.5 | | Descriptor: | MAGNESIUM ION, RNA (5'-R(*GP*GP*CP*CP*CP*C)-3') | | Authors: | Mateja-Pluta, M, Kiliszek, A. | | Deposit date: | 2024-03-12 | | Release date: | 2024-05-01 | | Last modified: | 2024-07-03 | | Method: | X-RAY DIFFRACTION (0.918 Å) | | Cite: | Antisense RNA C9orf72 hexanucleotide repeat associated with amyotrophic lateral sclerosis and frontotemporal dementia forms a triplex-like structure and binds small synthetic ligand.
Nucleic Acids Res., 52, 2024
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