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3IBB
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BU of 3ibb by Molmil
Propionyl-CoA Carboxylase Beta Subunit, D422A
Descriptor: Propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L, Arabolaza, A, Shillito, E.M, Lin, T.-W, Mitchell, D.L, Pham, H, Melgar, M.M.
Deposit date:2009-07-15
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.
Biochemistry, 49, 2010
1XNW
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Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #2, mutant D422I
Descriptor: propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C.
Deposit date:2004-10-05
Release date:2004-11-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
3MFM
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BU of 3mfm by Molmil
Crystal Structures and Mutational Analyses of Acyl-CoA Carboxylase Subunit of Streptomyces coelicolor
Descriptor: Propionyl-CoA carboxylase complex B subunit
Authors:Diacovich, L, Arabolaza, A, Shillito, E.M, Lin, T.-W, Mitchell, D.L, Melgar, M.M.
Deposit date:2010-04-02
Release date:2010-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.
Biochemistry, 49, 2010
3IAV
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BU of 3iav by Molmil
Propionyl-CoA Carboxylase Beta Subunit, D422V
Descriptor: Propionyl-CoA carboxylase complex B subunit, SULFATE ION
Authors:Diacovich, L, Arabolaza, A, Shillito, E.M, Lin, T.-W, Mitchell, D.L, Pham, H, Melgar, M.M.
Deposit date:2009-07-14
Release date:2010-06-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor.
Biochemistry, 49, 2010
5CTB
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BU of 5ctb by Molmil
Humanized yeast ACC carboxyltransferase domain bound to 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one
Descriptor: 6,7-dimethyl-1'-[(7-methyl-1H-indazol-5-yl)carbonyl]spiro[chromene-2,4'-piperidin]-4(3H)-one, Acetyl-CoA carboxylase, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
5CTE
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BU of 5cte by Molmil
Humanized yeast ACC carboxyltransferase domain bound to 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate
Descriptor: 2,2-dimethylpropyl (1S)-1-methyl-8-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,8-diazaspiro[4.5]decane-2-carboxylate, Acetyl-CoA carboxylase, SULFATE ION
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
5CTC
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BU of 5ctc by Molmil
Humanized yeast ACC carboxyltransferase domain bound to tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate
Descriptor: Acetyl-CoA carboxylase, SULFATE ION, tert-butyl 7-[(7-methyl-1H-indazol-5-yl)carbonyl]-2,7-diazaspiro[3.5]nonane-2-carboxylate
Authors:Vajdos, F.F.
Deposit date:2015-07-23
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg.Med.Chem.Lett., 25, 2015
5FIF
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BU of 5fif by Molmil
Carboxyltransferase domain of a single-chain bacterial carboxylase
Descriptor: 1,2-ETHANEDIOL, Carboxylase
Authors:Hagmann, A, Hunkeler, M, Stuttfeld, E, Maier, T.
Deposit date:2015-12-23
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.494 Å)
Cite:Hybrid Structure of a Dynamic Single-Chain Carboxylase from Deinococcus radiodurans.
Structure, 24, 2016
1UYV
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BU of 1uyv by Molmil
Acetyl-CoA carboxylase carboxyltransferase domain L1705I/V1967I mutant
Descriptor: ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
1VRG
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BU of 1vrg by Molmil
Crystal structure of propionyl-CoA carboxylase, beta subunit (TM0716) from THERMOTOGA MARITIMA at 2.30 A resolution
Descriptor: BICARBONATE ION, MAGNESIUM ION, propionyl-CoA carboxylase, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2005-02-22
Release date:2005-03-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of propionyl-CoA carboxylase, beta subunit (TM0716) from THERMOTOGA MARITIMA at 2.30 A resolution
To be published
1W2X
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BU of 1w2x by Molmil
Crystal structure of the carboxyltransferase domain of acetyl- coenzyme A carboxylase in complex with CP-640186
Descriptor: (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Li, J, Tong, L.
Deposit date:2004-07-09
Release date:2004-09-09
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Carboxyltransferase Domain of Acetyl-Coenzyme a Carboxylase in Complex with Cp-640186
Structure, 12, 2004
1UYT
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BU of 1uyt by Molmil
Acetyl-CoA carboxylase carboxyltransferase domain
Descriptor: ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop.
Proc.Natl.Acad.Sci.USA, 101, 2004
1UYS
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BU of 1uys by Molmil
Acetyl-CoA carboxylase carboxyltransferase domain in complex with inhibitor haloxyfop
Descriptor: (2R)-2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid, ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
1UYR
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BU of 1uyr by Molmil
Acetyl-CoA Carboxylase Carboxyltransferase Domain in complex with inhibitor Diclofop
Descriptor: 2-[4-(2,4-DICHLOROPHENOXY)PHENOXY]PROPANOIC ACID, ACETYL-COA CARBOXYLASE
Authors:Zhang, H, Tweel, B, Tong, L.
Deposit date:2004-03-02
Release date:2004-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Basis for the Inhibition of the Carboxyltransferase Domain of Acetyl-Coenzyme-A Carboxylase by Haloxyfop and Diclofop
Proc.Natl.Acad.Sci.USA, 101, 2004
1X0U
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BU of 1x0u by Molmil
Crystal Structure of the carboxyl transferase subunit of putative PCC of Sulfolobus tokodaii
Descriptor: hypothetical methylmalonyl-CoA decarboxylase alpha subunit
Authors:Kakuta, Y, Sueda, S, Kondo, H.
Deposit date:2005-03-29
Release date:2006-07-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the carboxyl transferase subunit of putative PCC of Sulfolobus tokodaii
To be Published
3TV5
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BU of 3tv5 by Molmil
Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 1
Descriptor: (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, Acetyl-CoA carboxylase
Authors:Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F.
Deposit date:2011-09-19
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
J.Biol.Chem., 286, 2011
3TVW
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BU of 3tvw by Molmil
Crystal Structure of the humanized carboxyltransferase domain of yeast Acetyl-coA caroxylase in complex with compound 4
Descriptor: Acetyl-CoA carboxylase, [4-(2H-chromen-3-ylmethyl)piperazin-1-yl]-[3-(1H-pyrazol-5-yl)phenyl]methanone
Authors:Rajamohan, F, Marr, E, Reyes, A, Landro, J.A, Anderson, M.D, Corbett, J.W, Dirico, K.J, Harwood, J.H, Tu, M, Vajdos, F.F.
Deposit date:2011-09-20
Release date:2011-10-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion.
J.Biol.Chem., 286, 2011
3FF6
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BU of 3ff6 by Molmil
Human ACC2 CT domain with CP-640186
Descriptor: (3R)-1'-(9-ANTHRYLCARBONYL)-3-(MORPHOLIN-4-YLCARBONYL)-1,4'-BIPIPERIDINE, Acetyl-CoA carboxylase 2
Authors:Williams, S.P, Madauss, K.P, Burkhart, W.A.
Deposit date:2008-12-02
Release date:2009-05-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist.
Acta Crystallogr.,Sect.D, 65, 2009
3H0Q
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BU of 3h0q by Molmil
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 3
Descriptor: 4-({4-[(2-methylquinolin-6-yl)methyl]piperidin-1-yl}carbonyl)-2-phenylquinoline, Acetyl-CoA carboxylase
Authors:Zhang, H, Tong, L.
Deposit date:2009-04-10
Release date:2010-04-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorg.Med.Chem.Lett., 20, 2010
3GF7
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BU of 3gf7 by Molmil
Glutaconyl-coA decarboxylase A subunit from Clostridium symbiosum apoprotein
Descriptor: Glutaconyl-CoA decarboxylase subunit A, SULFATE ION
Authors:Kress, D, Brugel, D, Buckel, W, Essen, L.-O.
Deposit date:2009-02-26
Release date:2009-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases
J.Biol.Chem., 284, 2009
5INI
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BU of 5ini by Molmil
Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics
Descriptor: HEXANOYL-COENZYME A, Putative carboxyl transferase
Authors:Valentic, T.R, Ray, L, Miyazawa, T, Withall, D.M, Song, L, Milligan, J.C, Osada, H, Tsai, S.C, Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
3H0S
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BU of 3h0s by Molmil
Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with compound 7
Descriptor: 1'-(1H-indazol-7-ylcarbonyl)-6-methylspiro[chromene-2,4'-piperidin]-4(3H)-one, Acetyl-CoA carboxylase, SULFATE ION
Authors:Vajdos, F.
Deposit date:2009-04-10
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.
Bioorg.Med.Chem.Lett., 20, 2010
5ING
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BU of 5ing by Molmil
A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender unit
Descriptor: Putative carboxyl transferase
Authors:Valentic, T.R, Ray, L, Miyazawa, T, Song, L, Withall, D.M, Milligan, J.C, Takahashi, S, Osada, H, Tsai, S.C, Challis, G.L.
Deposit date:2016-03-07
Release date:2016-12-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units.
Nat Commun, 7, 2016
3TDC
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BU of 3tdc by Molmil
Crystal Structure of Human Acetyl-CoA carboxylase 2
Descriptor: 1-[3-({4-[(5S)-3,3-dimethyl-1-oxo-2-oxa-7-azaspiro[4.5]dec-7-yl]piperidin-1-yl}carbonyl)-1-benzothiophen-2-yl]-3-ethylurea, Acetyl-CoA carboxylase 2 variant
Authors:Dougan, D.R, Mol, C.D.
Deposit date:2011-08-10
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
5IKL
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BU of 5ikl by Molmil
Crystal structure of P. aeruginosa geranyl-CoA carboxylase (GCC), beta subunit
Descriptor: Geranyl-CoA carboxylase, beta-subunit
Authors:Huang, C.S, Jurado, A.R, Tong, L.
Deposit date:2016-03-03
Release date:2016-04-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and substrate selectivity of the 750-kDa alpha6beta6 holoenzyme of geranyl-CoA carboxylase
Nat Commun, 6, 2015

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