7JP2
 
 | | Crystal structure of TP0037 from Treponema pallidum, a D-lactate dehydrogenase | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, D-lactate dehydrogenase | | Authors: | Brautigam, C.A, Deka, R.K, Norgard, M.V. | | Deposit date: | 2020-08-07 | | Release date: | 2020-09-09 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Biophysical and Biochemical Characterization of TP0037, a d-Lactate Dehydrogenase, Supports an Acetogenic Energy Conservation Pathway in Treponema pallidum.
Mbio, 11, 2020
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5N53
 | | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with N-(3-chloro-4-methoxyphenyl) acetamide | | Descriptor: | D-3-phosphoglycerate dehydrogenase, ~{N}-(3-chloranyl-4-methoxy-phenyl)ethanamide | | Authors: | Unterlass, J.E, Basle, A, Blackburn, T.J, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. | | Deposit date: | 2017-02-12 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
Oncotarget, 9, 2018
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7KWM
 | | CtBP1 (28-375) L182F/V185T - AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, C-terminal-binding protein 1, CALCIUM ION | | Authors: | Royer, W.E, Del Campo, M. | | Deposit date: | 2020-12-01 | | Release date: | 2021-02-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
J.Biol.Chem., 296, 2021
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5N6C
 | | Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with NAD and L-Tartrate | | Descriptor: | D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Unterlass, J.E, Basle, A, Tucker, J, Cano, C, Noble, M.E.M, Curtin, N.J. | | Deposit date: | 2017-02-14 | | Release date: | 2017-11-22 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH).
Oncotarget, 8, 2017
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5AOV
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2HU2
 | | CTBP/BARS in ternary complex with NAD(H) and RRTGAPPAL peptide | | Descriptor: | 9-mer peptide from Zinc finger protein 217, C-terminal-binding protein 1, FORMIC ACID, ... | | Authors: | Nardini, M, Bolognesi, M, Quinlan, K.G.R, Verger, A, Francescato, P, Crossley, M. | | Deposit date: | 2006-07-26 | | Release date: | 2006-10-31 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Specific Recognition of ZNF217 and Other Zinc Finger Proteins at a Surface Groove of C-Terminal Binding Proteins
Mol.Cell.Biol., 26, 2006
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1PSD
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1QP8
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1WWK
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5DNA
 | | Crystal structure of Candida boidinii formate dehydrogenase | | Descriptor: | FORMATE DEHYDROGENASE, SULFATE ION | | Authors: | Guo, Q, Gakhar, L, Wichersham, K, Francis, K, Vardi-Kilshtain, A, Major, D.T, Cheatum, C.M, Kohen, A. | | Deposit date: | 2015-09-09 | | Release date: | 2016-05-04 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.
Biochemistry, 55, 2016
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5DT9
 | | Crystal structure of a putative D-Erythronate-4-Phosphate Dehydrogenase from Vibrio cholerae | | Descriptor: | CHLORIDE ION, Erythronate-4-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Stogios, P.J, Skarina, T, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2015-09-17 | | Release date: | 2015-09-30 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.663 Å) | | Cite: | Crystal structure of a putative D-Erythronate-4-Phosphate Dehydrogenase from Vibrio cholerae
To Be Published
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5DN9
 | | Crystal structure of Candida boidinii formate dehydrogenase complexed with NAD+ and azide | | Descriptor: | AZIDE ION, CHLORIDE ION, FDH, ... | | Authors: | Guo, Q, Gakhar, L, Wichersham, K, Francis, K, Vardi-Kilshtain, A, Major, D.T, Cheatum, C.M, Kohen, A. | | Deposit date: | 2015-09-09 | | Release date: | 2016-05-04 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.
Biochemistry, 55, 2016
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7CVP
 | | The Crystal Structure of human PHGDH from Biortus. | | Descriptor: | D-3-phosphoglycerate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Wang, F, Lv, Z, Cheng, W, Lin, D, Miao, Q, Huang, Y. | | Deposit date: | 2020-08-26 | | Release date: | 2020-09-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Crystal Structure of human PHGDH from Biortus.
To Be Published
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1YBA
 | | The active form of phosphoglycerate dehydrogenase | | Descriptor: | 2-OXOGLUTARIC ACID, D-3-phosphoglycerate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Thompson, J.R, Banaszak, L.J. | | Deposit date: | 2004-12-20 | | Release date: | 2005-04-26 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Vmax Regulation through Domain and Subunit Changes. The Active Form of Phosphoglycerate Dehydrogenase
Biochemistry, 44, 2005
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6PLG
 | | Crystal structure of human PHGDH complexed with Compound 15 | | Descriptor: | (2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic acid, D-3-phosphoglycerate dehydrogenase, D-MALATE | | Authors: | Olland, A, Lakshminarasimhan, D, White, A, Suto, R.K. | | Deposit date: | 2019-06-30 | | Release date: | 2019-07-24 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
Bioorg.Med.Chem.Lett., 29, 2019
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7YA3
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7YA4
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8ARI
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8ATI
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3JTM
 | | Structure of recombinant formate dehydrogenase from Arabidopsis thaliana | | Descriptor: | AZIDE ION, Formate dehydrogenase, mitochondrial, ... | | Authors: | Timofeev, V.I, Shabalin, I.G, Serov, A.E, Polyakov, K.M, Popov, V.O, Tishkov, V.I, Kuranova, I.P, Samigina, V.R. | | Deposit date: | 2009-09-13 | | Release date: | 2010-09-15 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structure of recombinant formate dehydrogenase from Arabidopsis thaliana
to be published
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1YGY
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3K5P
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3NAQ
 | | Apo-form of NAD-dependent formate dehydrogenase from higher-plant Arabidopsis thaliana | | Descriptor: | Formate dehydrogenase, SULFATE ION | | Authors: | Shabalin, I.G, Polyakov, K.M, Serov, A.E, Skirgello, O.E, Sadykhov, E.G, Dorovatovskiy, P.V, Tishkov, V.I, Popov, V.O. | | Deposit date: | 2010-06-02 | | Release date: | 2010-07-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structures of the apo and holo forms of NAD-dependent formate dehydrogenase from the higher-plant Arabidopsis Thaliana
to be published
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3KB6
 | | Crystal structure of D-Lactate dehydrogenase from aquifex aeolicus complexed with NAD and Lactic acid | | Descriptor: | D-lactate dehydrogenase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | Authors: | Antonyuk, S.V, Strange, R.W, Ellis, M.J, Bessho, Y, Kuramitsu, S, Yokoyama, S, Hasnain, S.S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2009-10-20 | | Release date: | 2009-11-10 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Structure of D-lactate dehydrogenase from Aquifex aeolicus complexed with NAD(+) and lactic acid (or pyruvate).
Acta Crystallogr.,Sect.F, 65, 2009
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6PEX
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