2GQ1
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![BU of 2gq1 by Molmil](/molmil-images/mine/2gq1) | Crystal Structure of Recombinant Type I Fructose-1,6-bisphosphatase from Escherichia coli Complexed with Sulfate Ions | Descriptor: | Fructose-1,6-bisphosphatase, SULFATE ION | Authors: | Hines, J.K, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2006-04-19 | Release date: | 2006-05-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Novel Allosteric Activation Site in Escherichia coli Fructose-1,6-bisphosphatase. J.Biol.Chem., 281, 2006
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1YZ0
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![BU of 1yz0 by Molmil](/molmil-images/mine/1yz0) | R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase, ... | Authors: | Iancu, C.V, Mukund, S, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2005-02-25 | Release date: | 2005-03-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase. J.Biol.Chem., 280, 2005
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1YXI
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![BU of 1yxi by Molmil](/molmil-images/mine/1yxi) | R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase, MAGNESIUM ION, ... | Authors: | Iancu, C.V, Mukund, S, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2005-02-21 | Release date: | 2005-03-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase. J.Biol.Chem., 280, 2005
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5IZ1
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![BU of 5iz1 by Molmil](/molmil-images/mine/5iz1) | Physcomitrella patens FBPase | Descriptor: | fructose-1,6-bisphosphatase | Authors: | Einsle, O, Guetle, D. | Deposit date: | 2016-03-24 | Release date: | 2016-06-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Chloroplast FBPase and SBPase are thioredoxin-linked enzymes with similar architecture but different evolutionary histories. Proc.Natl.Acad.Sci.USA, 113, 2016
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5K55
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![BU of 5k55 by Molmil](/molmil-images/mine/5k55) | Human muscle fructose-1,6-bisphosphatase E69Q mutant in active R-state in complex with fructose-6-phosphate | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2016-05-23 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.977 Å) | Cite: | Structural studies of human muscle FBPase To Be Published
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1YYZ
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![BU of 1yyz by Molmil](/molmil-images/mine/1yyz) | R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase, ... | Authors: | Iancu, C.V, Mukund, S, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2005-02-25 | Release date: | 2005-03-15 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase. J.Biol.Chem., 280, 2005
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5K56
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![BU of 5k56 by Molmil](/molmil-images/mine/5k56) | Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-1,6-bisphosphate | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2016-05-23 | Release date: | 2017-06-07 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | Structural studies of human muscle FBPase To Be Published
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1SPI
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![BU of 1spi by Molmil](/molmil-images/mine/1spi) | CRYSTAL STRUCTURE OF SPINACH CHLOROPLAST FRUCTOSE-1,6-BISPHOSPHATASE AT 2.8 ANGSTROMS RESOLUTION | Descriptor: | FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Villeret, V, Huang, S, Zhang, Y, Xue, Y, Lipscomb, W.N. | Deposit date: | 1994-12-14 | Release date: | 1995-02-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of spinach chloroplast fructose-1,6-bisphosphatase at 2.8 A resolution. Biochemistry, 34, 1995
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2QVV
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![BU of 2qvv by Molmil](/molmil-images/mine/2qvv) | Porcine Liver Fructose-1,6-bisphosphatase cocrystallized with Fru-2,6-P2 and Zn2+, I(T)-state | Descriptor: | 2,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase 1, PHOSPHATE ION, ... | Authors: | Hines, J.K, Chen, X, Nix, J.C, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2007-08-08 | Release date: | 2007-10-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structures of mammalian and bacterial fructose-1,6-bisphosphatase reveal the basis for synergism in AMP/fructose 2,6-bisphosphate inhibition J.Biol.Chem., 282, 2007
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2VT5
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![BU of 2vt5 by Molmil](/molmil-images/mine/2vt5) | FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE -1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH A DUAL BINDING AMP SITE INHIBITOR | Descriptor: | 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE, FRUCTOSE-1,6-BISPHOSPHATASE 1 | Authors: | Ruf, A, Joseph, C, Benz, J, Fol, B, Tetaz, T. | Deposit date: | 2008-05-09 | Release date: | 2008-07-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Allosteric Fbpase Inhibitors Gain 10(5) Times in Potency When Simultaneously Binding Two Neighboring AMP Sites. Bioorg.Med.Chem.Lett., 18, 2008
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2WBB
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![BU of 2wbb by Molmil](/molmil-images/mine/2wbb) | FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR | Descriptor: | FRUCTOSE-1,6-BISPHOSPHATASE 1, N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE | Authors: | Ruf, A, Joseph, C, Benz, J, Fol, B, Tetaz, T, Kitas, E, Mohr, P, Kuhn, B, Wessel, H.P, Hebeisen, P, Haap, W, Huber, W, Alvarez Sanchez, R, Paehler, A, Bernadeau, A, Gubler, M, Schott, B, Tozzo, E. | Deposit date: | 2009-02-26 | Release date: | 2009-12-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.22 Å) | Cite: | Sulfonylureido Thiazoles as Fructose-1,6-Bisphosphatase Inhibitors for the Treatment of Type-2 Diabetes. Bioorg.Med.Chem.Lett., 20, 2010
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1RDX
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![BU of 1rdx by Molmil](/molmil-images/mine/1rdx) | R-STATE STRUCTURE OF THE ARG 243 TO ALA MUTANT OF PIG KIDNEY FRUCTOSE 1,6-BISPHOSPHATASE EXPRESSED IN E. COLI | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Stec, B, Abraham, R, Giroux, E, Kantrowitz, E.R. | Deposit date: | 1996-05-17 | Release date: | 1997-01-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Crystal structures of the active site mutant (Arg-243-->Ala) in the T and R allosteric states of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli. Protein Sci., 5, 1996
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2WBD
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![BU of 2wbd by Molmil](/molmil-images/mine/2wbd) | FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR | Descriptor: | FRUCTOSE-1,6-BISPHOSPHATASE 1, N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3-ethylbenzenesulfonamide | Authors: | Ruf, A, Joseph, C, Benz, J, Fol, B, Tetaz, T, Kitas, E, Mohr, P, Kuhn, B, Wessel, H.P, Hebeisen, P, Haap, W, Huber, W, Alvarez Sanchez, R, Paehler, A, Bernadeau, A, Gubler, M, Schott, B, Tozzo, E. | Deposit date: | 2009-02-26 | Release date: | 2009-12-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Sulfonylureido Thiazoles as Fructose-1,6-Bisphosphatase Inhibitors for the Treatment of Type-2 Diabetes. Bioorg.Med.Chem.Lett., 20, 2010
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1RDZ
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![BU of 1rdz by Molmil](/molmil-images/mine/1rdz) | T-STATE STRUCTURE OF THE ARG 243 TO ALA MUTANT OF PIG KIDNEY FRUCTOSE 1,6-BISPHOSPHATASE EXPRESSED IN E. COLI | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Stec, B, Abraham, R, Giroux, E, Kantrowitz, E.R. | Deposit date: | 1996-05-17 | Release date: | 1997-01-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures of the active site mutant (Arg-243-->Ala) in the T and R allosteric states of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli. Protein Sci., 5, 1996
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1RDY
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![BU of 1rdy by Molmil](/molmil-images/mine/1rdy) | T-STATE STRUCTURE OF THE ARG 243 TO ALA MUTANT OF PIG KIDNEY FRUCTOSE 1,6-BISPHOSPHATASE EXPRESSED IN E. COLI | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Stec, B, Abraham, R, Giroux, E, Kantrowitz, E.R. | Deposit date: | 1996-05-17 | Release date: | 1997-01-11 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of the active site mutant (Arg-243-->Ala) in the T and R allosteric states of pig kidney fructose-1,6-bisphosphatase expressed in Escherichia coli. Protein Sci., 5, 1996
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3IFC
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![BU of 3ifc by Molmil](/molmil-images/mine/3ifc) | Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP and alpha fructose-6-phosphate | Descriptor: | 6-O-phosphono-alpha-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase isozyme 2, ... | Authors: | Kolodziejczyk, R, Zarzycki, M, Jaskolski, M, Dzugaj, A. | Deposit date: | 2009-07-24 | Release date: | 2010-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase Acta Crystallogr.,Sect.D, 67, 2011
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3IFA
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![BU of 3ifa by Molmil](/molmil-images/mine/3ifa) | Human muscle fructose-1,6-bisphosphatase E69Q mutant in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase isozyme 2, GLYCEROL, ... | Authors: | Kolodziejczyk, R, Zarzycki, M, Jaskolski, M, Dzugaj, A. | Deposit date: | 2009-07-24 | Release date: | 2010-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase Acta Crystallogr.,Sect.D, 67, 2011
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5FBP
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![BU of 5fbp by Molmil](/molmil-images/mine/5fbp) | CRYSTAL STRUCTURE OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH THE PRODUCT FRUCTOSE 6-PHOSPHATE AT 2.1-ANGSTROMS RESOLUTION | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE | Authors: | Ke, H, Liang, J.-Y, Zhang, Y, Lipscomb, W.N. | Deposit date: | 1991-02-11 | Release date: | 1992-07-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the neutral form of fructose-1,6-bisphosphatase complexed with the product fructose 6-phosphate at 2.1-A resolution. Proc.Natl.Acad.Sci.USA, 88, 1991
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5ET5
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![BU of 5et5 by Molmil](/molmil-images/mine/5et5) | Human muscle fructose-1,6-bisphosphatase in active R-state | Descriptor: | Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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5ET8
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![BU of 5et8 by Molmil](/molmil-images/mine/5et8) | Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-11-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | T-to-R switch of muscle FBPase involves extreme changes of secondary and quaternary structure To Be Published
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5ET6
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![BU of 5et6 by Molmil](/molmil-images/mine/5et6) | Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.845 Å) | Cite: | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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5ET7
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![BU of 5et7 by Molmil](/molmil-images/mine/5et7) | Human muscle fructose-1,6-bisphosphatase in inactive T-state | Descriptor: | Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.989 Å) | Cite: | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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3KC0
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![BU of 3kc0 by Molmil](/molmil-images/mine/3kc0) | Crystal structure of human liver FBPase in complex with tricyclic inhibitor 10b | Descriptor: | Fructose-1,6-bisphosphatase 1, [(8H-indeno[1,2-d][1,3]thiazol-4-yloxy)methyl]phosphonic acid | Authors: | Takahashi, M, Sone, J, Hanzawa, H. | Deposit date: | 2009-10-20 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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2OWZ
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![BU of 2owz by Molmil](/molmil-images/mine/2owz) | R-state, citrate and Fru-6-P-bound Escherichia coli fructose-1,6-bisphosphatase | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, CITRIC ACID, Fructose-1,6-bisphosphatase | Authors: | Hines, J.K, Fromm, H.J, Honzatko, R.B. | Deposit date: | 2007-02-17 | Release date: | 2007-03-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structures of activated fructose-1,6-bisphosphatase from Escherichia coli. Coordinate regulation of bacterial metabolism and the conservation of the R-state. J.Biol.Chem., 282, 2007
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3KBZ
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![BU of 3kbz by Molmil](/molmil-images/mine/3kbz) | Crystal structure of human liver FBPase in complex with tricyclic inhibitor 6 | Descriptor: | Fructose-1,6-bisphosphatase 1, {[(2-amino-8H-indeno[1,2-d][1,3]thiazol-4-yl)oxy]methyl}phosphonic acid | Authors: | Takahashi, M, Sone, J, Hanzawa, H. | Deposit date: | 2009-10-20 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structure-based drug design of tricyclic 8H-indeno[1,2-d][1,3]thiazoles as potent FBPase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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