3K17
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6ZH0
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![BU of 6zh0 by Molmil](/molmil-images/mine/6zh0) | Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-N-(pyrimidin-2-yl)acetamide | Descriptor: | 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, N-(3-chlorophenyl)-2,2,2-trifluoroacetamide, ... | Authors: | Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. | Deposit date: | 2020-06-20 | Release date: | 2022-06-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia. Acs Chem.Biol., 16, 2021
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3K85
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1S4E
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![BU of 1s4e by Molmil](/molmil-images/mine/1s4e) | Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Galactokinase, MAGNESIUM ION, ... | Authors: | Hartley, A, Glynn, S.E, Barynin, V, Baker, P.J, Sedelnikova, S.E, Verhees, C, de Geus, D, van der Oost, J, Timson, D.J, Reece, R.J, Rice, D.W. | Deposit date: | 2004-01-16 | Release date: | 2004-04-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase J.Mol.Biol., 337, 2004
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4Z7Y
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![BU of 4z7y by Molmil](/molmil-images/mine/4z7y) | diphosphomevalonate decarboxylase from the Sulfolobus solfataricus, space group P21 | Descriptor: | Diphosphomevalonate decarboxylase, SULFATE ION | Authors: | Hattori, A, Unno, H, Hemmi, H. | Deposit date: | 2015-04-08 | Release date: | 2015-09-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | In Vivo Formation of the Protein Disulfide Bond That Enhances the Thermostability of Diphosphomevalonate Decarboxylase, an Intracellular Enzyme from the Hyperthermophilic Archaeon Sulfolobus solfataricus J.Bacteriol., 197, 2015
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3HUL
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6QJE
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![BU of 6qje by Molmil](/molmil-images/mine/6qje) | Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole | Descriptor: | 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, 4-[(2-methylsulfonylimidazol-1-yl)methyl]-1,3-thiazole, Galactokinase, ... | Authors: | Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. | Deposit date: | 2019-01-24 | Release date: | 2019-02-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of human galactokinase 1 bound with 4-{[2-(Methylsulfonyl)-1H-imidazol-1-yl]methyl}-1,3-thiazole To Be Published
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6Q90
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![BU of 6q90 by Molmil](/molmil-images/mine/6q90) | Structure of human galactokinase 1 bound with 1-(4-Methoxyphenyl)-3-(4-pyridinyl)urea | Descriptor: | 2-(1,3-benzoxazol-2-ylamino)spiro[1,6,7,8-tetrahydroquinazoline-4,1'-cyclohexane]-5-one, Galactokinase, N-(4-methoxyphenyl)-N'-pyridin-4-ylurea, ... | Authors: | Mackinnon, S.R, Bezerra, G.A, Zhang, M, Foster, W, Krojer, T, Brandao-Neto, J, Douangamath, A, Arrowsmith, C, Edwards, A, Bountra, C, Brennan, P, Lai, K, Yue, W.W. | Deposit date: | 2018-12-16 | Release date: | 2019-01-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of human galactokinase 1 bound with 1-(4-Methoxyphenyl)-3-(4-pyridinyl)urea To Be Published
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5V2M
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3V2U
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![BU of 3v2u by Molmil](/molmil-images/mine/3v2u) | Crystal structure of the yeast GAL regulon complex of the repressor, Gal80p, and the transducer, Gal3p, with galactose and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, Galactose/lactose metabolism regulatory protein GAL80, ... | Authors: | Lavy, T, Kumar, P.R, He, H, Joshua-Tor, L. | Deposit date: | 2011-12-12 | Release date: | 2012-02-08 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation. Genes Dev., 26, 2012
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4Z7C
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![BU of 4z7c by Molmil](/molmil-images/mine/4z7c) | Diphosphomevalonate decarboxylase from the Sulfolobus solfataricus, space group h32 | Descriptor: | Diphosphomevalonate decarboxylase, GLYCEROL, PHOSPHATE ION, ... | Authors: | Unno, H, Hattori, A, Hemmi, H. | Deposit date: | 2015-04-07 | Release date: | 2015-09-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | In Vivo Formation of the Protein Disulfide Bond That Enhances the Thermostability of Diphosphomevalonate Decarboxylase, an Intracellular Enzyme from the Hyperthermophilic Archaeon Sulfolobus solfataricus J.Bacteriol., 197, 2015
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5V2L
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1PIE
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1KKH
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![BU of 1kkh by Molmil](/molmil-images/mine/1kkh) | Crystal Structure of the Methanococcus jannaschii Mevalonate Kinase | Descriptor: | 1,4-DIETHYLENE DIOXIDE, Mevalonate Kinase | Authors: | Yang, D, Shipman, L.W, Roessner, C.A, Scott, A.I, Sacchettini, J.C. | Deposit date: | 2001-12-08 | Release date: | 2002-03-27 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of the Methanococcus jannaschii mevalonate kinase, a member of the GHMP kinase superfamily. J.Biol.Chem., 277, 2002
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5WAT
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![BU of 5wat by Molmil](/molmil-images/mine/5wat) | Corynebacterium glutamicum Full length Homoserine kinase | Descriptor: | HEXAETHYLENE GLYCOL, Homoserine kinase, MAGNESIUM ION, ... | Authors: | Petit, C, Ronning, D.R. | Deposit date: | 2017-06-27 | Release date: | 2018-02-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.141 Å) | Cite: | Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
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1KVK
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![BU of 1kvk by Molmil](/molmil-images/mine/1kvk) | The Structure of Binary complex between a Mammalian Mevalonate Kinase and ATP: Insights into the Reaction Mechanism and Human Inherited Disease | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, mevalonate kinase | Authors: | Fu, Z, Wang, M, Potter, D, Mizioko, H.M, Kim, J.J. | Deposit date: | 2002-01-26 | Release date: | 2002-03-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The Structure of a Binary complex
between a Mammalian Mevalonate Kinase and ATP: Insights into the
Reaction Mechanism and Human Inherited Disease J.Biol.Chem., 277, 2002
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1UEK
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![BU of 1uek by Molmil](/molmil-images/mine/1uek) | Crystal structure of 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase | Descriptor: | 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase | Authors: | Wada, T, Kuramitsu, S, Yokoyama, S, Tame, J.R.H, Park, S.Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-05-17 | Release date: | 2003-06-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an Enzyme in the Non-mevalonate Pathway of Isoprenoid Synthesis. J.Biol.Chem., 278, 2003
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5WAS
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![BU of 5was by Molmil](/molmil-images/mine/5was) | Corynebacterium glutamicum Hydrolyzed Homoserine kinase | Descriptor: | Homoserine kinase, PHOSPHATE ION | Authors: | Petit, C, Ronning, D.R. | Deposit date: | 2017-06-27 | Release date: | 2018-02-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Reduction of Feedback Inhibition in Homoserine Kinase (ThrB) ofCorynebacterium glutamicumEnhances l-Threonine Biosynthesis. ACS Omega, 3, 2018
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6TEP
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![BU of 6tep by Molmil](/molmil-images/mine/6tep) | Crystal structure of a galactokinase from Bifidobacterium infantis in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Keenan, T, Parmeggiani, F, Fontenelle, C.Q, Malassis, J, Vendeville, J, Offen, W.A, Both, P, Huang, K, Marchesi, A, Heyam, A, Young, C, Charnock, S, Davies, G.J, Linclau, B, Flitsch, S.L, Fascione, M.A. | Deposit date: | 2019-11-12 | Release date: | 2020-06-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides. Cell Chem Biol, 27, 2020
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6TEQ
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![BU of 6teq by Molmil](/molmil-images/mine/6teq) | Crystal structure of a galactokinase from Bifidobacterium infantis in complex with 2-deoxy-2-fluoro-galactose | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-deoxy-2-fluoro-alpha-D-galactopyranose, ... | Authors: | Keenan, T, Parmeggiani, F, Fontenelle, C.Q, Malassis, J, Vendeville, J, Offen, W.A, Both, P, Huang, K, Marchesi, A, Heyam, A, Young, C, Charnock, S, Davies, G.J, Linclau, B, Flitsch, S.L, Fascione, M.A. | Deposit date: | 2019-11-12 | Release date: | 2020-06-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides. Cell Chem Biol, 27, 2020
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6TER
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![BU of 6ter by Molmil](/molmil-images/mine/6ter) | Crystal structure of a galactokinase from Bifidobacterium infantis in complex with Galactose | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Keenan, T, Parmeggiani, F, Fontenelle, C.Q, Malassis, J, Vendeville, J, Offen, W.A, Both, P, Huang, K, Marchesi, A, Heyam, A, Young, C, Charnock, S, Davies, G.J, Linclau, B, Flitsch, S.L, Fascione, M.A. | Deposit date: | 2019-11-12 | Release date: | 2020-06-10 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides. Cell Chem Biol, 27, 2020
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1VIS
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![BU of 1vis by Molmil](/molmil-images/mine/1vis) | Crystal structure of mevalonate kinase | Descriptor: | 1,4-DIETHYLENE DIOXIDE, Mevalonate kinase | Authors: | Structural GenomiX | Deposit date: | 2003-12-01 | Release date: | 2003-12-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural analysis of a set of proteins resulting from a bacterial genomics project Proteins, 60, 2005
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1WUU
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![BU of 1wuu by Molmil](/molmil-images/mine/1wuu) | crystal structure of human galactokinase complexed with MgAMPPNP and galactose | Descriptor: | Galactokinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Thoden, J.B, Timson, D.J, Reece, R.J, Holden, H.M. | Deposit date: | 2004-12-08 | Release date: | 2004-12-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular Structure of Human Galactokinase: IMPLICATIONS FOR TYPE II GALACTOSEMIA J.Biol.Chem., 280, 2005
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6MDF
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6GR2
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![BU of 6gr2 by Molmil](/molmil-images/mine/6gr2) | Structure of human galactokinase in complex with galactose and ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Galactokinase, SULFATE ION, ... | Authors: | Bezerra, G.A, Mackinnon, S, Williams, E, Zhang, M, Arrowsmith, C, Edwards, A, Bountra, C, Lai, K, Yue, W.W, Structural Genomics Consortium (SGC) | Deposit date: | 2018-06-08 | Release date: | 2019-06-19 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structure of human galactokinase in complex with galactose and ADP To Be Published
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