PDB: 222415 resultsInfo pagesStatus searchChemie searchBIRD

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4IJK	Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695 Descriptor: 3-ketoacyl-acyl carrier protein reductase (FabG), SODIUM ION Authors: Hou, J, Osinski, T, Zheng, H, Shumilin, I, Shabalin, I.G, Shatsman, S, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2012-12-21 Release date: 2013-01-09 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from Helicobacter pylori 26695 To be Published
4IE7	Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with citrate and rhein (RHN) Descriptor: 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid, Alpha-ketoglutarate-dependent dioxygenase FTO, CITRATE ANION, ... Authors: Aik, W.S, McDonough, M.A, Schofield, C.J. Deposit date: 2012-12-13 Release date: 2013-04-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.6004 Å) Cite: Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56, 2013
4IFG	Crystal structure of TgCDPK1 with inhibitor bound Descriptor: 1-{(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one, Calmodulin-domain protein kinase 1, UNKNOWN ATOM OR ION Authors: El Bakkouri, M, Tempel, W, Crandall, I, Massad, T, Loppnau, P, Graslund, S, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Kain, K, Hui, R, Structural Genomics Consortium (SGC) Deposit date: 2012-12-14 Release date: 2014-04-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Crystal structure of TgCDPK1 with inhibitor bound To be Published
4INC	Human Histidine Triad Nucleotide Binding Protein 2 Descriptor: CHLORIDE ION, Histidine triad nucleotide-binding protein 2, mitochondrial Authors: Maize, K.M, Wagner, C.R, Finzel, B.C. Deposit date: 2013-01-04 Release date: 2013-05-22 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.19 Å) Cite: Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. Febs J., 280, 2013
4IG6	Crystal structure of a tRNA (guanine-N1)-methyltransferase from Anaplasma phagocytophilum bound to S-adenosylhomocysteine Descriptor: CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine-N(1)-)-methyltransferase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-12-16 Release date: 2012-12-26 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal structure of a tRNA (guanine-N1)-methyltransferase from Anaplasma phagocytophilum bound to S-adenosylhomocysteine TO BE PUBLISHED
4IHX	Crystal structure of Fis bound to 27 bp 2-Aminopurine substituted DNA F28-2AP (AAATTTGTTTGA2T2TTGAGCAAATTT) Descriptor: 27-bp DNA Strand A, 27-bp DNA Strand B, DNA-binding protein fis Authors: Hancock, S.P, Cascio, D, Johnson, R.C. Deposit date: 2012-12-19 Release date: 2013-05-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Control of DNA minor groove width and Fis protein binding by the purine 2-amino group. Nucleic Acids Res., 41, 2013
4IE6	Crystal structure of the human fat mass and obesity associated protein (FTO) in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9) Descriptor: Alpha-ketoglutarate-dependent dioxygenase FTO, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, ZINC ION Authors: Aik, W.S, McDonough, M.A, Schofield, C.J. Deposit date: 2012-12-13 Release date: 2013-04-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5036 Å) Cite: Structural basis for inhibition of the fat mass and obesity associated protein (FTO) J.Med.Chem., 56, 2013
4GN2	Crystal Structure of OXA-45, a Class D beta-lactamase with extended spectrum activity Descriptor: Oxacillinase Authors: Martin, J.D, Xiong, X.L, Catto, L.E, Toleman, M.A, Walsh, T.R, Clarke, A.R, Spencer, J. Deposit date: 2012-08-16 Release date: 2013-08-21 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Structural and Kinetic Characterization of OXA-45, a Class D beta-Lactamase with Extended Spectrum activity To be Published
4GBW	Crystal Structure of AMP complexes of Porcine Liver Fructose-1,6-bisphosphatase Mutant A54L with 1,2-propanediol as Cryo-protectant Descriptor: 6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... Authors: Honzatko, R.B, Gao, Y. Deposit date: 2012-07-28 Release date: 2013-08-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2 Å) Cite: Water Structure of the Central Hydrophobic Cavity of Mammalian Fructose-1,6-bisphosphatase: a Potential Thermodynamic Determinant of Allowed Quaternary States To be published
4GEG	Crystal Structure of E.coli MenH Y85F Mutant Descriptor: 1,2-ETHANEDIOL, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, CHLORIDE ION, ... Authors: Johnston, J.M, Baker, E.N, Guo, Z, Jiang, M. Deposit date: 2012-08-01 Release date: 2013-05-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Crystal Structures of E. coli Native MenH and Two Active Site Mutants. Plos One, 8, 2013
3D81	Sir2-S-alkylamidate complex crystal structure Descriptor: NAD-dependent deacetylase, S-alkylamidate intermediate, ZINC ION Authors: Hawse, W.F, Hoff, K.G, Fatkins, D, Daines, A, Zubkova, O.V, Schramm, V.L, Zheng, W, Wolberger, C. Deposit date: 2008-05-22 Release date: 2008-09-30 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure, 16, 2008
3CXM	Leishmania naiffi uracil-DNA glycosylase in complex with 5-bromouracil Descriptor: 5-bromopyrimidine-2,4(1H,3H)-dione, BROMIDE ION, GLYCEROL, ... Authors: Larson, E.T, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) Deposit date: 2008-04-24 Release date: 2008-05-06 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structures of Leishmania naiffi uracil-DNA glycosylase in complex with several ligands identified with fragment cocktail crystallography. To be Published
4GH8	Crystal structure of a 'humanized' E. coli dihydrofolate reductase Descriptor: CALCIUM ION, Dihydrofolate reductase, METHOTREXATE, ... Authors: French, J.B, Liu, C.T, Hanoian, P, Pringle, T.H, Hammes-Schiffer, S, Benkovic, S.J. Deposit date: 2012-08-07 Release date: 2013-06-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans. Proc.Natl.Acad.Sci.USA, 110, 2013
4GIQ	Crystal Structure of mouse RANK bound to RANKL Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SODIUM ION, ... Authors: Nelson, C.A, Wang, M.W.-H, Fremont, D.H. Deposit date: 2012-08-08 Release date: 2012-10-24 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.7 Å) Cite: RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor. Structure, 20, 2012
4GIV	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183 Descriptor: 3-(pyridin-3-yl)propyl (2S)-1-[(3-nitrophenyl)sulfonyl]piperidine-2-carboxylate, FORMIC ACID, Ubiquitin-like protein SMT3, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-08-09 Release date: 2012-09-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.45 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4GGQ	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 Descriptor: 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2012-08-07 Release date: 2012-08-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins. Antimicrob.Agents Chemother., 58, 2014
4GMA	Crystal structure of the adenosylcobalamin riboswitch Descriptor: Adenosylcobalamin, Adenosylcobalamin riboswitch Authors: Reyes, F.E, Johnson, J.E, Polaski, J.T, Batey, R.T. Deposit date: 2012-08-15 Release date: 2012-10-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.94 Å) Cite: B12 cofactors directly stabilize an mRNA regulatory switch. Nature, 492, 2012
4GMM	Structure of rat cytosolic PEPCK Ld_1g in complex with Beta-Sulfopyruvate and GTP Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-16 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.736 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
4GMW	Structure of rat cytosolic PEPCK Ld_1g in complex with PEP and GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, PHOSPHOENOLPYRUVATE, ... Authors: Johnson, T.A, Holyoak, T. Deposit date: 2012-08-16 Release date: 2013-07-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: The {Omega}-loop lid domain of phosphoenolpyruvate carboxykinase is essential for catalytic function. Biochemistry, 51, 2012
3CFN	Crystal structure of human transthyretin in complex with 1-anilino-8-naphthalene sulfonate Descriptor: 8-ANILINO-1-NAPHTHALENE SULFONATE, Transthyretin Authors: Lima, L.-M.T.R, Foguel, D, Polikarpov, I. Deposit date: 2008-03-04 Release date: 2009-03-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
4GJY	JMJD5 in complex with N-Oxalylglycine Descriptor: COBALT (II) ION, JmjC domain-containing protein 5, N-OXALYLGLYCINE Authors: Del Rizzo, P.A, Trievel, R.C. Deposit date: 2012-08-10 Release date: 2012-09-05 Last modified: 2012-11-14 Method: X-RAY DIFFRACTION (1.2492 Å) Cite: Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function. Mol.Cell.Biol., 32, 2012
4GK9	Crystal structure of Burkholderia oklahomensis agglutinin (BOA) bound to 3a,6a-mannopentaose Descriptor: IMIDAZOLE, SODIUM ION, agglutinin (BOA), ... Authors: Whitley, M.J, Furey, W, Gronenborn, A.M. Deposit date: 2012-08-10 Release date: 2013-05-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Burkholderia oklahomensis agglutinin is a canonical two-domain OAA-family lectin: structures, carbohydrate binding and anti-HIV activity. Febs J., 280, 2013
4GM2	The crystal structure of a peptidase from plasmodium falciparum Descriptor: ATP-dependent Clp protease proteolytic subunit Authors: El Bakkouri, M, Jung, P, Wernimont, A.K, Calmettes, C, Hui, R, Houry, W.A, Structural Genomics Consortium (SGC) Deposit date: 2012-08-15 Release date: 2012-12-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum. J.Biol.Chem., 288, 2013
4FG0	Structure of the St. Louis Encephalitis Virus envelope protein in the fusogenic trimer conformation. Descriptor: Polyprotein Authors: Luca, V.C, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) Deposit date: 2012-06-01 Release date: 2012-06-27 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (3.899 Å) Cite: Structure of the st. Louis encephalitis virus postfusion envelope trimer. J.Virol., 87, 2013
4FG3	Crystal Structure Analysis of the Human Insulin Descriptor: CHLORIDE ION, GLYCEROL, Insulin, ... Authors: Lima, L.M.T.R, Favero-Retto, M.P. Deposit date: 2012-06-02 Release date: 2013-06-12 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.001 Å) Cite: Structural meta-analysis of regular human insulin in pharmaceutical formulations. Eur J Pharm Biopharm, 85, 2013

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