5RJI
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![BU of 5rji by Molmil](/molmil-images/mine/5rji) | PanDDA analysis group deposition of ground-state model of PHIP | Descriptor: | PH-interacting protein | Authors: | Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. | Deposit date: | 2020-06-02 | Release date: | 2020-06-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | PanDDA analysis group deposition of ground-state model To Be Published
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5RJX
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![BU of 5rjx by Molmil](/molmil-images/mine/5rjx) | PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z285782452 | Descriptor: | N-methyl-2-(methylsulfonyl)aniline, PH-interacting protein | Authors: | Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. | Deposit date: | 2020-06-02 | Release date: | 2020-06-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.291 Å) | Cite: | PanDDA analysis group deposition of ground-state model To Be Published
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5RKD
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![BU of 5rkd by Molmil](/molmil-images/mine/5rkd) | PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z2168282707 | Descriptor: | (6S)-1-methyl-4,5,6,7-tetrahydro-1H-benzotriazole-6-carboxylic acid, PH-interacting protein | Authors: | Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. | Deposit date: | 2020-06-02 | Release date: | 2020-06-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.237 Å) | Cite: | PanDDA analysis group deposition of ground-state model To Be Published
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5RKU
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![BU of 5rku by Molmil](/molmil-images/mine/5rku) | PanDDA analysis group deposition -- Crystal Structure of PHIP in complex with Z32367954 | Descriptor: | PH-interacting protein, ~{N}-cyclopropyl-1,3-benzodioxole-5-carboxamide | Authors: | Grosjean, H, Aimon, A, Krojer, T, Talon, R, Douangamath, A, Koekemoer, L, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Biggin, P.C. | Deposit date: | 2020-06-02 | Release date: | 2020-06-17 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | PanDDA analysis group deposition of ground-state model To Be Published
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5KY8
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![BU of 5ky8 by Molmil](/molmil-images/mine/5ky8) | |
5L0R
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![BU of 5l0r by Molmil](/molmil-images/mine/5l0r) | human POGLUT1 in complex with Notch1 EGF12 and UDP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | Authors: | Li, Z, Rini, J.M. | Deposit date: | 2016-07-28 | Release date: | 2017-08-09 | Last modified: | 2021-03-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis of Notch O-glucosylation and O-xylosylation by mammalian protein-O-glucosyltransferase 1 (POGLUT1). Nat Commun, 8, 2017
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2M2U
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![BU of 2m2u by Molmil](/molmil-images/mine/2m2u) | |
2M2W
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![BU of 2m2w by Molmil](/molmil-images/mine/2m2w) | Ternary complex of ASFV Pol X with DNA and MgdGTP | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(P*GP*GP*CP*GP*AP*AP*GP*CP*CP*GP*GP*GP*TP*GP*CP*GP*AP*AP*GP*CP*AP*CP*(DOC))-3', MAGNESIUM ION, ... | Authors: | Wu, W, Su, M, Tsai, M. | Deposit date: | 2013-01-03 | Release date: | 2014-04-02 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | How a low-fidelity DNA polymerase chooses non-Watson-Crick from Watson-Crick incorporation. J.Am.Chem.Soc., 136, 2014
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2ML1
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![BU of 2ml1 by Molmil](/molmil-images/mine/2ml1) | |
5LEL
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![BU of 5lel by Molmil](/molmil-images/mine/5lel) | Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein | Descriptor: | DD_Off7_10_3G124, Green fluorescent protein, Maltose-binding periplasmic protein | Authors: | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | Deposit date: | 2016-06-30 | Release date: | 2017-11-15 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Rigidly connected multispecific artificial binders with adjustable geometries. Sci Rep, 7, 2017
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5LDF
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![BU of 5ldf by Molmil](/molmil-images/mine/5ldf) | |
5LOF
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![BU of 5lof by Molmil](/molmil-images/mine/5lof) | Crystal structure of the MBP-MCL1 complex with highly selective and potent inhibitor of MCL1 | Descriptor: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(5-fluoranylfuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-[2,2,2-tris(fluoranyl)ethyl]pyrazol-3-yl]methoxy]phenyl]propanoic acid, Maltose-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Dokurno, P, Kotschy, A, Szlavik, Z, Murray, J, Davidson, J, Csekei, M, Paczal, A, Szabo, Z, Sipos, S, Radics, G, Proszenyak, A, Balint, B, Ondi, L, Blasko, G, Robertson, A, Surgenor, A, Chen, I, Matassova, N, Smith, J, Pedder, C, Graham, C, Geneste, O. | Deposit date: | 2016-08-09 | Release date: | 2016-10-26 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature, 538, 2016
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2M2V
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![BU of 2m2v by Molmil](/molmil-images/mine/2m2v) | |
2ML3
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![BU of 2ml3 by Molmil](/molmil-images/mine/2ml3) | |
2ML2
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![BU of 2ml2 by Molmil](/molmil-images/mine/2ml2) | |
9BCG
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![BU of 9bcg by Molmil](/molmil-images/mine/9bcg) | Myeloid cell leukemia-1 (Mcl-1) complexed with compound | Descriptor: | 7-[(4R,5S,6P)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)-3,4-dihydropyrazino[1,2-a]indol-2(1H)-yl]-4,5-dimethoxy-1-methyl-1H-indole-2-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | Authors: | Zhao, B, Fesik, S.W. | Deposit date: | 2024-04-09 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.898 Å) | Cite: | Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor that Demonstrates Potent in Vivo Activities in Mouse Models of Hematological and Solid Tumors J.Med.Chem., 2024
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8ZQE
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![BU of 8zqe by Molmil](/molmil-images/mine/8zqe) | Cryo-EM structure of the GPR15L(C11)-bound GPR15 complex | Descriptor: | GPR15, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, Z.Y, Zheng, Y, Xu, F. | Deposit date: | 2024-06-02 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15. Cell Discov, 10, 2024
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8ZMS
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![BU of 8zms by Molmil](/molmil-images/mine/8zms) | Acetylcholine-bound VAChT | Descriptor: | ACETYLCHOLINE, Maltose/maltodextrin-binding periplasmic protein,Vesicular acetylcholine transporter,DARPinoff7 | Authors: | Zhang, Z, Zhang, Y, Dai, F, Zhang, Y.X, Lee, C.-H. | Deposit date: | 2024-05-23 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into VAChT neurotransmitter recognition and inhibition. Cell Res., 2024
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8XB4
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![BU of 8xb4 by Molmil](/molmil-images/mine/8xb4) | |
8XB2
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![BU of 8xb2 by Molmil](/molmil-images/mine/8xb2) | Structure of radafaxine-bound state of the human Norepinephrine Transporter | Descriptor: | (2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter | Authors: | Wu, J.X, Ji, W.M. | Deposit date: | 2023-12-05 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Substrate binding and inhibition mechanism of norepinephrine transporter To Be Published
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8XB3
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![BU of 8xb3 by Molmil](/molmil-images/mine/8xb3) | |
8ZMR
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![BU of 8zmr by Molmil](/molmil-images/mine/8zmr) | Vesamicol-bound VAChT | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Vesicular acetylcholine transporter,DARPinoff7, vesamicol | Authors: | Zhang, Z, Zhang, Y, Dai, F, Zhang, Y.X, Lee, C.-H. | Deposit date: | 2024-05-23 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural insights into VAChT neurotransmitter recognition and inhibition. Cell Res., 2024
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7MQ7
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![BU of 7mq7 by Molmil](/molmil-images/mine/7mq7) | Tetragonal Maltose Binding Protein | Descriptor: | CHLORIDE ION, Maltodextrin-binding protein, SULFATE ION, ... | Authors: | Thaker, A, Sirajudeen, L, Simmons, C.R, Nannenga, B.L. | Deposit date: | 2021-05-05 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure-guided identification of a peptide for bio-enabled gold nanoparticle synthesis. Biotechnol.Bioeng., 118, 2021
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7MQ6
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![BU of 7mq6 by Molmil](/molmil-images/mine/7mq6) | Tetragonal Maltose Binding Protein in the presence of gold | Descriptor: | CHLORIDE ION, GOLD ION, Maltodextrin-binding protein, ... | Authors: | Thaker, A, Sirajudeen, L, Simmons, C.R, Nannenga, B.L. | Deposit date: | 2021-05-05 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.372 Å) | Cite: | Structure-guided identification of a peptide for bio-enabled gold nanoparticle synthesis. Biotechnol.Bioeng., 118, 2021
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7MN6
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![BU of 7mn6 by Molmil](/molmil-images/mine/7mn6) | Structure of the HER2 S310F/HER3/NRG1b Heterodimer Extracellular Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ... | Authors: | Diwanji, D, Trenker, R, Verba, K.A, Jura, N. | Deposit date: | 2021-04-30 | Release date: | 2021-10-27 | Last modified: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021
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