PDB: 12060 resultsInfo pagesStatus searchChemie searchBIRD

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3LLU	Crystal structure of the nucleotide-binding domain of Ras-related GTP-binding protein C Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related GTP-binding protein C, ... Authors: Nedyalkova, L, Tempel, W, Tong, Y, Crombet, L, Zhong, N, Guan, X, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2010-01-29 Release date: 2010-02-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of the nucleotide-binding domain of Ras-related GTP-binding protein C to be published
4UOE	Crystal Structure of Plasmodium Falciparum Spermidine Synthase in Complex with 5'-Deoxy-5'-Methylioadenosine and 4-Aminomethylaniline Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 4-(aminomethyl)aniline, 5'-DEOXY-5'-METHYLTHIOADENOSINE, ... Authors: Sprenger, J, Halander, J.C, Svensson, B, Al-Karadaghi, S, Person, L. Deposit date: 2014-06-03 Release date: 2014-10-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design. Acta Crystallogr.,Sect.D, 71, 2015
3LX9	Interconversion of Human Lysosomal Enzyme Specificities Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... Authors: Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. Deposit date: 2010-02-25 Release date: 2010-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
3LSL	Piracetam bound to the ligand binding domain of GluA2 (flop form) Descriptor: 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2010-02-12 Release date: 2010-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.122 Å) Cite: Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors. J.Med.Chem., 53, 2010
4UPJ	HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 PROTEASE MUTANT WITH LYS 57 REPLACED BY LEU (K57L) COMPLEX WITH U097410 [4-HYDROXY-3-[1-[3-[[[[(TERT-BUTYLOXYCARBONYL) AMINOMETHYL]CARBONYL]AMINO]PHENYL]PROPYL]COUMARIN Descriptor: ({3-[1-(4-HYDROXY-2-OXO-2H-CHROMEN-3-YL)-PROPYL]-PHENYLCARBAMOYL}-METHYL)-CARBAMIC ACID TERT-BUTYL ESTER, HIV-2 PROTEASE Authors: Watenpaugh, K.D, Mulichak, A.M, Janakiraman, M.N. Deposit date: 1996-03-04 Release date: 1996-10-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-based design of novel HIV protease inhibitors: carboxamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent nonpeptidic inhibitors. J.Med.Chem., 38, 1995
3LYF	Crystal Structure of the Rift Valley Fever Virus Nucleocapsid Protein Descriptor: GLYCEROL, Nucleocapsid protein Authors: Raymond, D.D, Smith, J.L. Deposit date: 2010-02-26 Release date: 2010-06-30 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation. Proc.Natl.Acad.Sci.USA, 107, 2010
3LXA	Interconversion of Human Lysosomal Enzyme Specificities Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... Authors: Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. Deposit date: 2010-02-25 Release date: 2010-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.04 Å) Cite: Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
4UCP	CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A FRAGMENT Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, N-methyl-1-[3-(morpholin-4-ylmethyl)phenyl]methanamine, TETRADECANOYL-COA Authors: Robinson, D.A, Wyatt, P.G. Deposit date: 2014-12-04 Release date: 2015-05-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Identification and Structure Solution of Fragment Hits Against Kinetoplastid N-Myristoyltransferase Acta Crystallogr.,Sect.F, 71, 2015
4UCN	CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A FRAGMENT Descriptor: 2-PIPERAZIN-1-YL-ANILINE, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, TETRADECANOYL-COA Authors: Robinson, D.A, Wyatt, P.G. Deposit date: 2014-12-04 Release date: 2015-05-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Identification and Structure Solution of Fragment Hits Against Kinetoplastid N-Myristoyltransferase Acta Crystallogr.,Sect.F, 71, 2015
3LXR	Shigella IpgB2 in complex with human RhoA and GDP (complex C) Descriptor: GUANOSINE-5'-DIPHOSPHATE, IpgB2, SULFATE ION, ... Authors: Klink, B.U, Barden, S, Heidler, T.V, Borchers, C, Ladwein, M, Stradal, T.E.B, Rottner, K, Heinz, D.W. Deposit date: 2010-02-25 Release date: 2010-03-31 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Structure of Shigella IPGB2 in complex with human RhoA: Implications for the mechanism of bacterial GEF-mimicry J.Biol.Chem., 285, 2010
3LXC	Interconversion of Human Lysosomal Enzyme Specificities Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, GLYCEROL, ... Authors: Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. Deposit date: 2010-02-25 Release date: 2010-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
3LWB	Crystal Structure of apo D-alanine:D-alanine Ligase (Ddl) from Mycobacterium tuberculosis Descriptor: D-alanine--D-alanine ligase, NITRATE ION Authors: Bruning, J.B, Murillo, A.C, Chacon, O, Barletta, R.G, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) Deposit date: 2010-02-23 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of the Mycobacterium tuberculosis D-Alanine:D-Alanine Ligase, a Target of the Antituberculosis Drug D-Cycloserine. Antimicrob.Agents Chemother., 55, 2011
3LXB	Interconversion of Human Lysosomal Enzyme Specificities Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... Authors: Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. Deposit date: 2010-02-25 Release date: 2010-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285, 2010
3M3F	PEPA bound to the ligand binding domain of GluA3 (flop form) Descriptor: 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, GLUTAMIC ACID, Glutamate receptor 3, ... Authors: Ahmed, A.H, Ptak, C.P, Oswald, R.E. Deposit date: 2010-03-09 Release date: 2010-03-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry, 49, 2010
3M91	Crystal structure of the prokaryotic ubiquitin-like protein (Pup) complexed with the amino terminal coiled coil of the Mycobacterium tuberculosis proteasomal ATPase Mpa Descriptor: Prokaryotic ubiquitin-like protein pup, Proteasome-associated ATPase Authors: Wang, T, Li, H. Deposit date: 2010-03-19 Release date: 2010-10-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation. Nat.Struct.Mol.Biol., 17, 2010
3MAU	Crystal structure of StSPL in complex with phosphoethanolamine Descriptor: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, PHOSPHATE ION, sphingosine-1-phosphate lyase, ... Authors: Bourquin, F, Grutter, M.G, Capitani, G. Deposit date: 2010-03-24 Release date: 2010-08-18 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism. Structure, 18, 2010
3MCY	Crystal structure of FimH lectin domain bound to biphenyl mannoside meta-methyl ester. Descriptor: CALCIUM ION, CHLORIDE ION, FimH, ... Authors: Ford, B.A, Hultgren, S.J. Deposit date: 2010-03-29 Release date: 2010-06-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure-based drug design and optimization of mannoside bacterial FimH antagonists. J.Med.Chem., 53, 2010
3MKJ	Methionine gamma-lyase from Citrobacter freundii with pyridoximine-5'-phosphate Descriptor: Methionine gamma-lyase, [5-hydroxy-4-(iminomethyl)-6-methyl-pyridin-3-yl]methyl dihydrogen phosphate Authors: Revtovich, S.V, Nikulin, A.D, Morozova, E.A, Demidkina, T.V. Deposit date: 2010-04-15 Release date: 2010-08-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Exploring methionine gamma-lyase structure-function relationship via microspectrophotometry and X-ray crystallography Biochim.Biophys.Acta, 1814, 2011
3MKT	Structure of a Cation-bound Multidrug and Toxin Compound Extrusion (MATE) transporter Descriptor: Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE-like MDR efflux pump Authors: He, X, Szewczyk, P, Karyakin, A, Evin, M, Hong, W.-X, Zhang, Q, Chang, G. Deposit date: 2010-04-15 Release date: 2010-09-29 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3.65 Å) Cite: Structure of a cation-bound multidrug and toxic compound extrusion transporter. Nature, 467, 2010
4UV8	LSD1(KDM1A)-CoREST in complex with 1-Benzyl-Tranylcypromine Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4S)-5-[(4aS,10aS)-4a-[(1S)-3-azanylidene-1,4-diphenyl-butyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-5,10a-dihydro-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate Authors: Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. Deposit date: 2014-08-05 Release date: 2014-09-10 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014
3MNO	Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, F608S) mutations at 1.55A Descriptor: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ... Authors: Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A. Deposit date: 2010-04-22 Release date: 2010-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. J.Mol.Biol., 403, 2010
3MRV	Glycogen phosphorylase complexed with 3-hydroxybenzaldehyde-4-(beta-D-glucopyranosyl) thiosemicarbazone Descriptor: DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... Authors: Alexacou, K.-M. Deposit date: 2010-04-29 Release date: 2011-01-05 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.94 Å) Cite: The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
4W96	Crystal structure of cross-linked tetragonal hen egg white lysozyme soaked with 5mM [Ru(CO)3Cl2]2 followed by the reaction in deoxy-myoglobin solution Descriptor: CHLORIDE ION, DIMETHYLFORMAMIDE, Lysozyme C, ... Authors: Tabe, H, Fujita, K, Abe, S, Tsujimoto, M, Kuchimaru, T, Kizaka-Kondo, S, Takano, M, Kitagawa, S, Ueno, T. Deposit date: 2014-08-27 Release date: 2014-12-31 Last modified: 2020-01-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Preparation of a Cross-Linked Porous Protein Crystal Containing Ru Carbonyl Complexes as a CO-Releasing Extracellular Scaffold Inorg.Chem., 54, 2015
3MT8	Glycogen phosphorylase complexed with 4-chlorobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone Descriptor: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(4-chlorophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine Authors: Alexacou, K.-M. Deposit date: 2010-04-30 Release date: 2011-01-05 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
4UYL	Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with VNI Descriptor: 14-ALPHA STEROL DEMETHYLASE, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, PROTOPORPHYRIN IX CONTAINING FE Authors: Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. Deposit date: 2014-09-01 Release date: 2015-08-19 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.81 Å) Cite: Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (Cyp51B) from Aspergillus Fumigatus and Molecular Basis for the Development of Antifungal Drugs J.Biol.Chem., 290, 2015

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