4UYL

Crystal structure of sterol 14-alpha demethylase (CYP51B) from a pathogenic filamentous fungus Aspergillus fumigatus in complex with VNI

Summary for 4UYL

• Entry DOI: 10.2210/pdb4uyl/pdb
• Related: 4UYM
• Descriptor: 14-ALPHA STEROL DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide, ... (4 entities in total)
• Functional Keywords: cytochrome p450, oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, oxidoreductase-oxidoreductase inhibitor complex
• Biological source: ASPERGILLUS FUMIGATUS
• Total number of polymer chains: 2
• Total formula weight: 108741.33

Authors

Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (deposition date: 2014-09-01, release date: 2015-08-19, Last modification date: 2024-01-10)

• Primary citation: Hargrove, T.Y.,Warwzak, Z.,Lamb, D.C.,Guengerich, F.P.,Lepesheva, G.I.; Structure-Functional Characterization of Cytochrome P450 Sterol Alpha-Demethylase (Cyp51B) from Aspergillus Fumigatus and Molecular Basis for the Development of Antifungal Drugs; J.Biol.Chem., 290:23916-, 2015; PubMed: 26269599; DOI: 10.1074/JBC.M115.677310

Experimental method

X-RAY DIFFRACTION (2.81 Å)