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1KLK
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BU of 1klk by Molmil
CRYSTAL STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TERNARY COMPLEX WITH PT653 AND NADPH
Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE
Authors:Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Rosowsky, A, Queener, S.F.
Deposit date:2001-12-12
Release date:2002-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.
Acta Crystallogr.,Sect.D, 58, 2002
4TX4
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BU of 4tx4 by Molmil
Crystal Structure of a Single-Domain Cysteine Protease Inhibitor from Cowpea (Vigna unguiculata)
Descriptor: Cysteine proteinase inhibitor, SULFATE ION
Authors:Pereira, H.M, Valadares, N, Monteiro-Junior, J.E, Carvalho, C.P.S, Grangeiro, T.B.
Deposit date:2014-07-02
Release date:2015-10-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Expression in Escherichia coli of cysteine protease inhibitors from cowpea (Vigna unguiculata): The crystal structure of a single-domain cystatin gives insights on its thermal and pH stability.
Int. J. Biol. Macromol., 102, 2017
4UUU
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BU of 4uuu by Molmil
1.7 A resolution structure of human cystathionine beta-synthase regulatory domain (del 516-525) in complex with SAM
Descriptor: 1,2-ETHANEDIOL, CYSTATHIONINE BETA-SYNTHASE, S-ADENOSYLMETHIONINE
Authors:Kopec, J, McCorvie, T.J, Fitzpatrick, F, Strain-Damerell, C, Froese, D.S, Tallant, C, Burgess-Brown, N, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W.
Deposit date:2014-07-31
Release date:2014-08-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Inter-Domain Communication of Human Cystathionine Beta Synthase: Structural Basis of S-Adenosyl-L-Methionine Activation.
J.Biol.Chem., 289, 2014
1CXX
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BU of 1cxx by Molmil
MUTANT R122A OF QUAIL CYSTEINE AND GLYCINE-RICH PROTEIN, NMR, MINIMIZED STRUCTURE
Descriptor: CYSTEINE AND GLYCINE-RICH PROTEIN CRP2, ZINC ION
Authors:Kloiber, K, Weiskirchen, R, Kraeutler, B, Bister, K, Konrat, R.
Deposit date:1999-08-31
Release date:1999-09-08
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Mutational analysis and NMR spectroscopy of quail cysteine and glycine-rich protein CRP2 reveal an intrinsic segmental flexibility of LIM domains.
J.Mol.Biol., 292, 1999
6L0R
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BU of 6l0r by Molmil
Crystal Structure of the O-Phosphoserine Sulfhydrylase from Aeropyrum pernix Complexed with O-Acetylserine
Descriptor: (2S)-3-acetyloxy-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]propanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, Protein CysO
Authors:Nakabayashi, M, Takeda, E, Ishikawa, K, Nakamura, T.
Deposit date:2019-09-26
Release date:2020-09-23
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Identification of amino acid residues important for recognition of O-phospho-l-serine substrates by cysteine synthase.
J.Biosci.Bioeng., 131, 2021
1VA6
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BU of 1va6 by Molmil
Crystal structure of Gamma-glutamylcysteine synthetase from Escherichia Coli B complexed with Transition-state analogue
Descriptor: (2S)-2-AMINO-4-[[(2R)-2-CARBOXYBUTYL](PHOSPHONO)SULFONIMIDOYL]BUTANOIC ACID, ADENOSINE-5'-DIPHOSPHATE, Glutamate--cysteine ligase, ...
Authors:Hibi, T, Nii, H, Nakatsu, T, Kato, H, Hiratake, J, Oda, J.
Deposit date:2004-02-12
Release date:2004-10-05
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
PROC.NATL.ACAD.SCI.USA, 101, 2004
8SJ5
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BU of 8sj5 by Molmil
Walnut Tree Phytocystatin
Descriptor: Cysteine proteinase inhibitor
Authors:Valadares, N.F.
Deposit date:2023-04-17
Release date:2023-12-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure and interconversion of monomers and domain-swapped dimers of the walnut tree phytocystatin.
Biochim Biophys Acta Proteins Proteom, 1872, 2023
6AIP
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BU of 6aip by Molmil
Cab2 mutant-H337A complex with phosphopantothenoylcystine
Descriptor: (5R,12R,17R)-17-amino-12-carboxy-1,1,5-trihydroxy-4,4-dimethyl-6,10-dioxo-2-oxa-14,15-dithia-7,11-diaza-1-phosphaoctadecan-18-oic acid 1-oxide (non-preferred name), Phosphopantothenate--cysteine ligase CAB2
Authors:Zheng, P, Zhu, Z.
Deposit date:2018-08-24
Release date:2019-03-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae.
J. Mol. Biol., 431, 2019
3GAX
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BU of 3gax by Molmil
Crystal structure of monomeric human cystatin C stabilized against aggregation
Descriptor: Cystatin-C
Authors:Kolodziejczyk, R, Michalska, K, Hernandez-Santoyo, A, Wahlbom, M, Grubb, A, Jaskolski, M.
Deposit date:2009-02-18
Release date:2010-02-23
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human cystatin C stabilized against amyloid formation.
Febs J., 277, 2010
1CEW
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BU of 1cew by Molmil
THE 2.0 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF CHICKEN EGG WHITE CYSTATIN AND ITS POSSIBLE MODE OF INTERACTION WITH CYSTEINE PROTEINASES
Descriptor: CYSTATIN
Authors:Bode, W, Musil, D, Huber, R.
Deposit date:1993-04-21
Release date:1994-01-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases.
EMBO J., 7, 1988
7XOY
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BU of 7xoy by Molmil
Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine and serine.
Descriptor: Putative cystathionine beta-synthase Rv1077, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
Authors:Bandyopadhyay, P, Pramanick, I, Biswas, R, Sabarinath, P.S, Sreedharan, S, Singh, S, Rajmani, R, Laxman, S, Dutta, S, Singh, A.
Deposit date:2022-05-01
Release date:2022-05-25
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:S-Adenosylmethionine-responsive cystathionine beta-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.
Sci Adv, 8, 2022
7XOH
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BU of 7xoh by Molmil
Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine.
Descriptor: Probable cystathionine beta-synthase Rv1077
Authors:Bandyopadhyay, P, Pramanick, I, Biswas, R, Sabarinath, P.S, Sreedharan, S, Singh, S, Rajmani, R, Laxman, S, Dutta, S, Singh, A.
Deposit date:2022-05-01
Release date:2022-05-25
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:S-Adenosylmethionine-responsive cystathionine beta-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.
Sci Adv, 8, 2022
6KG1
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BU of 6kg1 by Molmil
NifS from Helicobacter pylori, soaked with L-cysteine for 180 sec
Descriptor: 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-PROPIONIC ACID, CHLORIDE ION, Cysteine desulfurase IscS, ...
Authors:Nakamura, R, Takahashi, Y, Fujishiro, T.
Deposit date:2019-07-09
Release date:2019-10-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Snapshots of PLP-substrate and PLP-product external aldimines as intermediates in two types of cysteine desulfurase enzymes.
Febs J., 287, 2020
4LZI
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BU of 4lzi by Molmil
Characterization of Solanum tuberosum Multicystatin and Significance of Core Domains
Descriptor: Multicystatin
Authors:Nissen, M.S, Kumar, G.N, Green, A.R, Knowles, N.R, Kang, C.
Deposit date:2013-07-31
Release date:2014-02-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of Solanum tuberosum Multicystatin and the Significance of Core Domains.
Plant Cell, 25, 2013
9FXQ
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BU of 9fxq by Molmil
Ancestral Prenylcysteine Oxidase 1 (PCYOX1)
Descriptor: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ancestral Prenylcysteine Oxidase 1 (PCYOX1), FLAVIN-ADENINE DINUCLEOTIDE
Authors:Barone, M, Mattevi, A.
Deposit date:2024-07-02
Release date:2024-10-16
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Evolution, structure, and drug-metabolizing activity of mammalian prenylcysteine oxidases.
J.Biol.Chem., 300, 2024
2NX6
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BU of 2nx6 by Molmil
Structure of NOWA cysteine rich domain 6
Descriptor: Nematocyst outer wall antigen
Authors:Meier, S, Jensen, P.R, Adamczyk, P, Bachinger, H.P, Holstein, T.W, Engel, J, Ozbek, S, Grzesiek, S.
Deposit date:2006-11-17
Release date:2007-10-02
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
J.Mol.Biol., 368, 2007
2NX7
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BU of 2nx7 by Molmil
Structure of NOWA cysteine rich domain 8
Descriptor: Nematocyst outer wall antigen
Authors:Meier, S, Jensen, P.R, Adamczyk, P, Bachinger, H.P, Holstein, T.W, Engel, J, Ozbek, S, Grzesiek, S.
Deposit date:2006-11-17
Release date:2007-10-02
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.
J.Mol.Biol., 368, 2007
4LW2
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BU of 4lw2 by Molmil
Structural changes during cysteine desulfurase CsdA and sulfur-acceptor CsdE interactions provide insight into the trans-persulfuration
Descriptor: Cysteine sulfinate desulfinase, GLYCEROL, PYRIDOXAL-5'-PHOSPHATE
Authors:Kim, S, Park, S.Y.
Deposit date:2013-07-26
Release date:2013-08-07
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural changes during cysteine desulfurase CsdA and sulfur acceptor CsdE interactions provide insight into the trans-persulfuration.
J.Biol.Chem., 288, 2013
6ROA
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BU of 6roa by Molmil
Crystal structure of V57G mutant of human cystatin C
Descriptor: Cystatin-C
Authors:Orlikowska, M, Behrendt, I, Borek, D, Otwinowski, Z, Skowron, P, Szymanska, A.
Deposit date:2019-05-10
Release date:2019-08-07
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution.
Febs J., 287, 2020
6I1M
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BU of 6i1m by Molmil
Secreted type 1 cystatin from Fasciola hepatica
Descriptor: Cystatin, IODIDE ION
Authors:Busa, M, Rezacova, P, Pachl, P, Stefanic, S, Mares, M.
Deposit date:2018-10-29
Release date:2020-08-26
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.
J.Biol.Chem., 299, 2023
2CH9
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BU of 2ch9 by Molmil
Crystal structure of dimeric human cystatin F
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Schuettelkopf, A.W, van Aalten, D.M.F.
Deposit date:2006-03-13
Release date:2006-04-04
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis of Reduction-Dependent Activation of Human Cystatin F.
J.Biol.Chem., 281, 2006
2LOE
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BU of 2loe by Molmil
Structure of the Plasmodium 6-cysteine s48/45 Domain
Descriptor: 6-cysteine protein, putative
Authors:Cai, M, Arredondo, S.A, Clore, M.G, Miller, L.H, Takayama, Y, Macdonald, N.J, Enderson, E.D, Aravind, L.
Deposit date:2012-01-23
Release date:2012-04-18
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Structure of the Plasmodium 6-cysteine s48/45 domain.
Proc.Natl.Acad.Sci.USA, 109, 2012
7P3L
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BU of 7p3l by Molmil
Isopenicillin N synthase in complex with Fe and the substrate analogue AadCyshomoCys
Descriptor: 2-AMINOHEXANEDIOIC ACID, CYSTEINE, D-homocysteine, ...
Authors:Rabe, P, Clifton, I, Schofield, C.J.
Deposit date:2021-07-08
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Isopenicillin N synthase in complex with Fe and the substrate analogue AadCyshomoCys
To Be Published
6CDX
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BU of 6cdx by Molmil
High-resolution crystal structure of fluoropropylated cystine knot, binding to alpha-5 beta-6 integrin
Descriptor: cystine knot (fluoropropylated)
Authors:Kimura, R, Nix, J, Bongura, C, Chakraborti, S, Gambhir, S, Filipp, F.V.
Deposit date:2018-02-09
Release date:2019-08-14
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1 Å)
Cite:Evaluation of integrin alpha v beta6cystine knot PET tracers to detect cancer and idiopathic pulmonary fibrosis.
Nat Commun, 10, 2019
1N2T
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BU of 1n2t by Molmil
C-DES Mutant K223A with GLY Covalenty Linked to the PLP-cofactor
Descriptor: GLYCINE, L-cysteine/cystine lyase C-DES, POTASSIUM ION, ...
Authors:Kaiser, J.T, Bruno, S, Clausen, T, Huber, R, Schiaretti, F, Mozzarelli, A, Kessler, D.
Deposit date:2002-10-24
Release date:2003-01-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Snapshots of the Cystine Lyase "C-DES" during Catalysis: Studies in Solution and in the Crystalline State
J.Biol.Chem., 278, 2003

238582

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