4KGT
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2O6N
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3DL0
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![BU of 3dl0 by Molmil](/molmil-images/mine/3dl0) | Crystal structure of adenylate kinase variant AKlse3 | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION, ... | Authors: | Bannen, R.M, Bianchetti, C.M, Bingman, C.A, McCoy, J.G. | Deposit date: | 2008-06-26 | Release date: | 2009-06-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Effectiveness and limitations of local structural entropy optimization in the thermal stabilization of mesophilic and thermophilic adenylate kinases. Proteins, 82, 2014
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4M6A
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![BU of 4m6a by Molmil](/molmil-images/mine/4m6a) | N-Terminal beta-Strand Swapping in a Consensus Derived Alternative Scaffold Driven by Stabilizing Hydrophobic Interactions | Descriptor: | Tencon | Authors: | Luo, J, Teplyakov, A, Obmolova, G, Malia, T.J, Chan, W, Jocobs, S.A, O'neil, K.T, Gilliland, G.L. | Deposit date: | 2013-08-09 | Release date: | 2014-02-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | N-terminal beta-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions. Proteins, 82, 2014
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4J8Y
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![BU of 4j8y by Molmil](/molmil-images/mine/4j8y) | E3_5 DARPin D77S mutant | Descriptor: | DARPin_E3_5_D77S | Authors: | Seeger, M.A, Gruetter, M.G. | Deposit date: | 2013-02-15 | Release date: | 2013-08-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci., 22, 2013
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5CY5
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![BU of 5cy5 by Molmil](/molmil-images/mine/5cy5) | Crystal structure of the T33-51H designed self-assembling protein tetrahedron | Descriptor: | T33-51H-A, T33-51H-B | Authors: | Cannon, K.A, Cascio, D, Park, R, Boyken, S, King, N, Yeates, T.O. | Deposit date: | 2015-07-30 | Release date: | 2016-08-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Design and structure of two new protein cages illustrate successes and ongoing challenges in protein engineering. Protein Sci., 29, 2020
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4LPT
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3DKV
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![BU of 3dkv by Molmil](/molmil-images/mine/3dkv) | Crystal structure of adenylate kinase variant AKlse1 | Descriptor: | 1,2-ETHANEDIOL, Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, ... | Authors: | Bannen, R.M, Bianchetti, C.M, Bingman, C.A, Bitto, E.B. | Deposit date: | 2008-06-26 | Release date: | 2009-06-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structure of adenylate kinase variant AKlse1. To be Published
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5A0O
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![BU of 5a0o by Molmil](/molmil-images/mine/5a0o) | adhiron raised against p300 | Descriptor: | ADHIRON | Authors: | Kyle, H.F, Wickson, K.F, Stott, J, Burslem, G.M, Breeze, A.L, Tiede, C, Tomlinson, D.C, Warriner, S.L, Nelson, A, Wilson, A.J, Edwards, T.A. | Deposit date: | 2015-04-21 | Release date: | 2015-07-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Exploration of the Hif-1Alpha.P300 Interface Using Peptide and Adhiron Phage Display Technologies Mol.Biosyst., 11, 2015
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4LPX
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5AEI
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![BU of 5aei by Molmil](/molmil-images/mine/5aei) | Designed Armadillo repeat protein YIIIM5AII in complex with peptide (KR)5 | Descriptor: | ACETATE ION, CALCIUM ION, DESIGNED ARMADILLO REPEAT PROTEIN YIIIM5AII, ... | Authors: | Hansen, S, Tremmel, D, Madhurantakam, C, Reichen, C, Mittl, P, Plueckthun, A. | Deposit date: | 2015-08-31 | Release date: | 2016-03-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure and Energetic Contributions of a Designed Modular Peptide-Binding Protein with Picomolar Affinity. J.Am.Chem.Soc., 138, 2016
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4LT9
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![BU of 4lt9 by Molmil](/molmil-images/mine/4lt9) | Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR404 | Descriptor: | Engineered Protein OR404 | Authors: | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Sahdev, S, Xiao, R, Kogan, S, Maglaqui, M, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-07-23 | Release date: | 2013-08-14 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure of Engineered Protein OR404. To be Published
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3CSG
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3CSU
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![BU of 3csu by Molmil](/molmil-images/mine/3csu) | CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE | Descriptor: | CALCIUM ION, PROTEIN (ASPARTATE CARBAMOYLTRANSFERASE) | Authors: | Beernink, P.T, Endrizzi, J.A, Alber, T, Schachman, H.K. | Deposit date: | 1999-04-22 | Release date: | 1999-05-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Assessment of the allosteric mechanism of aspartate transcarbamoylase based on the crystalline structure of the unregulated catalytic subunit. Proc.Natl.Acad.Sci.USA, 96, 1999
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4DB6
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![BU of 4db6 by Molmil](/molmil-images/mine/4db6) | Designed Armadillo repeat protein (YIIIM3AII) | Descriptor: | Armadillo repeat protein | Authors: | Madhurantakam, C, Varadamsetty, G, Grutter, M.G, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2012-01-13 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci., 21, 2012
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4DBA
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![BU of 4dba by Molmil](/molmil-images/mine/4dba) | Designed Armadillo repeat protein (YIIM3AII) | Descriptor: | Designed Armadillo repeat protein, YIIM3AII, GLYCEROL | Authors: | Madhurantakam, C, Varadamsetty, G, Grutter, M.G, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2012-01-13 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci., 21, 2012
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4DB8
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![BU of 4db8 by Molmil](/molmil-images/mine/4db8) | Designed Armadillo-repeat Protein | Descriptor: | Armadillo-repeat Protein, MAGNESIUM ION | Authors: | Madhurantakam, C, Varadamsetty, G, Grutter, M.G, Pluckthun, A, Mittl, P.R.E. | Deposit date: | 2012-01-13 | Release date: | 2012-05-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based optimization of designed Armadillo-repeat proteins. Protein Sci., 21, 2012
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2P05
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![BU of 2p05 by Molmil](/molmil-images/mine/2p05) | Structural Insights into the Evolution of a Non-Biological Protein | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... | Authors: | Smith, M, Rosenow, M, Wang, M, Allen, J.P, Szostak, J.W, Chaput, J.C. | Deposit date: | 2007-02-28 | Release date: | 2007-06-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization. PLoS ONE, 2, 2007
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3E79
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![BU of 3e79 by Molmil](/molmil-images/mine/3e79) | Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37 | Descriptor: | 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, CALCIUM ION, CHLORIDE ION, ... | Authors: | Sippel, K.H, Robbins, A.H, Reutzel, R, Domsic, J, McKenna, R. | Deposit date: | 2008-08-18 | Release date: | 2008-10-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37. Acta Crystallogr.,Sect.D, 64, 2008
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2V40
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![BU of 2v40 by Molmil](/molmil-images/mine/2v40) | Human Adenylosuccinate synthetase isozyme 2 in complex with GDP | Descriptor: | ADENYLOSUCCINATE SYNTHETASE ISOZYME 2, GUANOSINE-5'-DIPHOSPHATE | Authors: | Welin, M, Moche, M, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg-Schiavone, L, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Tresaugues, L, van den Berg, S, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-27 | Release date: | 2007-07-10 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Human Adenylosuccinate Synthetase Isozyme 2 in Complex with Gdp To be Published
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2V30
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![BU of 2v30 by Molmil](/molmil-images/mine/2v30) | Human orotidine 5'-phosphate decarboxylase domain of uridine monophospate synthetase (UMPS) in complex with its product UMP. | Descriptor: | OROTIDINE 5'-PHOSPHATE DECARBOXYLASE, URIDINE-5'-MONOPHOSPHATE | Authors: | Moche, M, Ogg, D, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Dahlgren, L.G, Edwards, A, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg-Schiavone, L, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Lehtio, L, Nyman, T, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, van den Berg, S, Weigelt, J, Welin, M, Nordlund, P, Structural Genomics Consortium (SGC) | Deposit date: | 2007-06-10 | Release date: | 2007-07-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of Human Orotidine 5'-Decarboxylase Domain of Human Uridine Monophosphate Synthetase (Umps) To be Published
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1P4R
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![BU of 1p4r by Molmil](/molmil-images/mine/1p4r) | Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD | Descriptor: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Bifunctional purine biosynthesis protein PURH, N-[(S)-(4-{[(2-AMINO-4-HYDROXYQUINAZOLIN-6-YL)(DIHYDROXY)-LAMBDA~4~-SULFANYL]AMINO}PHENYL)(HYDROXY)METHYL]-L-GLUTAMIC ACID, ... | Authors: | Cheong, C.-G, Greasley, S.E, Horton, P.A, Beardsley, G.P, Wilson, I.A. | Deposit date: | 2003-04-23 | Release date: | 2004-03-30 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates J.Biol.Chem., 279, 2004
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3KD7
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3F2E
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![BU of 3f2e by Molmil](/molmil-images/mine/3f2e) | Crystal structure of Yellowstone SIRV coat protein C-terminus | Descriptor: | CITRIC ACID, SIRV coat protein | Authors: | Taurog, R.E, Szymczyna, B.R, Williamson, J.R, Johnson, J.E. | Deposit date: | 2008-10-29 | Release date: | 2009-04-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.668 Å) | Cite: | Synergy of NMR, computation, and X-ray crystallography for structural biology. Structure, 17, 2009
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3LI1
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![BU of 3li1 by Molmil](/molmil-images/mine/3li1) | Crystal structure of the mutant I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | Descriptor: | 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID, Orotidine 5'-phosphate decarboxylase | Authors: | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | Deposit date: | 2010-01-23 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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