6ZSE
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![BU of 6zse by Molmil](/molmil-images/mine/6zse) | Human mitochondrial ribosome in complex with mRNA, A/P-tRNA and P/E-tRNA | Descriptor: | 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... | Authors: | Aibara, S, Singh, V, Modelska, A, Amunts, A. | Deposit date: | 2020-07-15 | Release date: | 2020-09-16 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Structural basis of mitochondrial translation. Elife, 9, 2020
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6ZSB
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![BU of 6zsb by Molmil](/molmil-images/mine/6zsb) | Human mitochondrial ribosome in complex with mRNA and P-site tRNA | Descriptor: | 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... | Authors: | Aibara, S, Singh, V, Modelska, A, Amunts, A. | Deposit date: | 2020-07-15 | Release date: | 2020-09-16 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural basis of mitochondrial translation. Elife, 9, 2020
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7F3F
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![BU of 7f3f by Molmil](/molmil-images/mine/7f3f) | CryoEM structure of human Kv4.2-KChIP1 complex | Descriptor: | Isoform 2 of Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | Authors: | Kise, Y, Nureki, O. | Deposit date: | 2021-06-16 | Release date: | 2021-10-13 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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8SO0
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![BU of 8so0 by Molmil](/molmil-images/mine/8so0) | Cryo-EM structure of the PP2A:B55-FAM122A complex | Descriptor: | FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ... | Authors: | Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. | Deposit date: | 2023-04-28 | Release date: | 2023-10-25 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (2.79961 Å) | Cite: | Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
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7RAO
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3UVK
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![BU of 3uvk by Molmil](/molmil-images/mine/3uvk) | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL2 | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Histone-lysine N-methyltransferase MLL2, SULFATE ION, ... | Authors: | Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. | Deposit date: | 2011-11-30 | Release date: | 2011-12-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
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6DKQ
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![BU of 6dkq by Molmil](/molmil-images/mine/6dkq) | Crystal structure of the Shr Hemoglobin Interacting Domain 2 | Descriptor: | Heme-binding protein Shr, SULFATE ION | Authors: | Macdonald, R, Cascio, D, Collazo, M.J, Clubb, R.T. | Deposit date: | 2018-05-30 | Release date: | 2018-10-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains. J.Biol.Chem., 293, 2018
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6P4F
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![BU of 6p4f by Molmil](/molmil-images/mine/6p4f) | Crystal structure of the XPB-Bax1-forked DNA ternary complex | Descriptor: | CHLORIDE ION, DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*AP*AP*CP*AP*TP*CP*CP*TP*TP*TP*GP*CP*TP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*GP*TP*AP*GP*GP*TP*TP*TP*CP*CP*AP*TP*GP*TP*TP*GP*AP*GP*TP*CP*A)-3'), ... | Authors: | He, F, Hilario, E, Fan, L. | Deposit date: | 2019-05-27 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.55 Å) | Cite: | Structural basis of the XPB helicase-Bax1 nuclease complex interacting with the repair bubble DNA. Nucleic Acids Res., 48, 2020
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3UVN
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![BU of 3uvn by Molmil](/molmil-images/mine/3uvn) | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1A | Descriptor: | Histone-lysine N-methyltransferase SETD1A, WD repeat-containing protein 5 | Authors: | Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. | Deposit date: | 2011-11-30 | Release date: | 2011-12-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.792 Å) | Cite: | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
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3UVL
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![BU of 3uvl by Molmil](/molmil-images/mine/3uvl) | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 | Descriptor: | Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5 | Authors: | Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. | Deposit date: | 2011-11-30 | Release date: | 2011-12-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
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3UVM
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![BU of 3uvm by Molmil](/molmil-images/mine/3uvm) | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4 | Descriptor: | Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5 | Authors: | Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. | Deposit date: | 2011-11-30 | Release date: | 2011-12-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
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3UVO
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![BU of 3uvo by Molmil](/molmil-images/mine/3uvo) | Crystal structure of WDR5 in complex with the WDR5-interacting motif of SET1B | Descriptor: | Histone-lysine N-methyltransferase SETD1B, WD repeat-containing protein 5 | Authors: | Zhang, P, Lee, H, Brunzelle, J.S, Couture, J.-F. | Deposit date: | 2011-11-30 | Release date: | 2011-12-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res., 40, 2012
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2G44
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![BU of 2g44 by Molmil](/molmil-images/mine/2g44) | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-1M-G and A Glucocorticoid Receptor Interacting Protein 1 NR Box II Peptide | Descriptor: | 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Rajan, S.S, Hsieh, R.W, Sharma, S.K, Greene, G.L. | Deposit date: | 2006-02-21 | Release date: | 2007-01-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Discovery and characterization of novel estrogen
receptor agonist ligands and development of biochips for
nuclear receptor drug discovery Thesis, 2006
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7F69
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![BU of 7f69 by Molmil](/molmil-images/mine/7f69) | Crystal structure of WIPI2b in complex with ATG16L1 | Descriptor: | Isoform 2 of Autophagy-related protein 16-1, Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2 | Authors: | Gong, X.Y, Pan, L.F. | Deposit date: | 2021-06-24 | Release date: | 2022-07-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | ATG16L1 adopts a dual-binding site mode to interact with WIPI2b in autophagy. Sci Adv, 9, 2023
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8FLU
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![BU of 8flu by Molmil](/molmil-images/mine/8flu) | Human PTH1R in complex with LA-PTH and Gs | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Cary, B.P, Belousoff, M.J, Piper, S.J, Wootten, D, Sexton, P.M. | Deposit date: | 2022-12-22 | Release date: | 2023-04-26 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (2.76 Å) | Cite: | Molecular insights into peptide agonist engagement with the PTH receptor. Structure, 31, 2023
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4WBQ
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![BU of 4wbq by Molmil](/molmil-images/mine/4wbq) | Crystal structure of the exonuclease domain of QIP (QDE-2 interacting protein) solved by native-SAD phasing. | Descriptor: | CALCIUM ION, QDE-2-interacting protein | Authors: | Boland, A, Weinert, T, Weichenrieder, O, Wang, M. | Deposit date: | 2014-09-03 | Release date: | 2014-12-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.693 Å) | Cite: | Fast native-SAD phasing for routine macromolecular structure determination. Nat.Methods, 12, 2015
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8FGX
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![BU of 8fgx by Molmil](/molmil-images/mine/8fgx) | Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasma kallikrein light chain, STAR-0215 Heavy chain, ... | Authors: | Fuller, J.R, Biris, N, Bista, P. | Deposit date: | 2022-12-13 | Release date: | 2023-09-06 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema. J.Pharmacol.Exp.Ther., 387, 2023
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8F44
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![BU of 8f44 by Molmil](/molmil-images/mine/8f44) | Crystal structure of SARS-CoV-2 3CL protease in complex with a dimethyl phenyl sulfane inhibitor | Descriptor: | (1R,2S)-1-hydroxy-2-[(N-{[2-methyl-2-(phenylsulfanyl)propoxy]carbonyl}-L-leucyl)amino]-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (2-methyl-2-phenylsulfanyl-propyl) ~{N}-[(2~{S})-1-[[(1~{S},2~{S})-1-[bis(oxidanyl)-oxidanylidene-$l^{5}-sulfanyl]-1-oxidanyl-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]carbamate, 3C-like proteinase, ... | Authors: | Liu, L, Lovell, S, Cooper, A, Battaile, K.P, Dampalla, C.S, Groutas, W.C. | Deposit date: | 2022-11-10 | Release date: | 2022-11-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV). Eur.J.Med.Chem., 254, 2023
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4ZN9
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![BU of 4zn9 by Molmil](/molmil-images/mine/4zn9) | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Oxabicyclic Heptene Sulfonate (OBHS) | Descriptor: | Estrogen receptor, Nuclear receptor-interacting peptide, cyclohexa-2,5-dien-1-yl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate | Authors: | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | Deposit date: | 2015-05-04 | Release date: | 2015-09-09 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.215 Å) | Cite: | Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands. Chemmedchem, 7, 2012
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7CE4
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![BU of 7ce4 by Molmil](/molmil-images/mine/7ce4) | Tankyrase2 catalytic domain in complex with K-476 | Descriptor: | 5-[3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-2-oxidanylidene-4H-quinazolin-1-yl]-2-fluoranyl-benzenecarbonitrile, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... | Authors: | Takahashi, Y, Suzuki, M, Saito, J. | Deposit date: | 2020-06-22 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8 + T cells to tumors. Am J Cancer Res, 11, 2021
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1P9D
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![BU of 1p9d by Molmil](/molmil-images/mine/1p9d) | |
7DKL
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![BU of 7dkl by Molmil](/molmil-images/mine/7dkl) | |
8IJS
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![BU of 8ijs by Molmil](/molmil-images/mine/8ijs) | anti-VEGF nanobody mutant | Descriptor: | ZINC ION, anti-VEGF nanobody | Authors: | Qian, F, Zhu, S.Q. | Deposit date: | 2023-02-28 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.752 Å) | Cite: | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration. Bioeng Transl Med, 8, 2023
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8IIU
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![BU of 8iiu by Molmil](/molmil-images/mine/8iiu) | anti-VEGF nanobody | Descriptor: | SULFATE ION, anti-VEGF nanobody | Authors: | Qian, F, Zhu, S.Q. | Deposit date: | 2023-02-24 | Release date: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.27 Å) | Cite: | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration. Bioeng Transl Med, 8, 2023
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8IJZ
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![BU of 8ijz by Molmil](/molmil-images/mine/8ijz) | anti-VEGF mutant | Descriptor: | anti-VEGF nanobody | Authors: | Qian, F, Zhu, S.Q. | Deposit date: | 2023-02-28 | Release date: | 2023-12-27 | Method: | ELECTRON CRYSTALLOGRAPHY (2.1 Å) | Cite: | Polymorphic nanobody crystals as long-acting intravitreal therapy for wet age-related macular degeneration. Bioeng Transl Med, 8, 2023
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