PDB: 1133 resultsInfo pagesStatus searchChemie searchBIRD

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6HXI	Structure of ATP citrate lyase from Methanothrix soehngenii in complex with citrate and coenzyme A Descriptor: ACETATE ION, CITRATE ANION, COENZYME A, ... Authors: Verstraete, K, Verschueren, K. Deposit date: 2018-10-17 Release date: 2019-04-10 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature, 568, 2019
4C6X	Crystal structure of M. tuberculosis C171Q KasA in complex with thiolactomycin (TLM) Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate, 1,2-ETHANEDIOL, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, ... Authors: Schiebel, J, Kapilashrami, K, Fekete, A, Bommineni, G.R, Schaefer, C.M, Mueller, M.J, Tonge, P.J, Kisker, C. Deposit date: 2013-09-19 Release date: 2013-10-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis J.Biol.Chem., 288, 2013
4C6W	Crystal structure of M. tuberculosis C171Q KasA Descriptor: (2R)-2-(hexadecanoyloxy)-3-{[(10R)-10-methyloctadecanoyl]oxy}propyl phosphate, 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Schiebel, J, Kapilashrami, K, Fekete, A, Bommineni, G.R, Schaefer, C.M, Mueller, M.J, Tonge, P.J, Kisker, C. Deposit date: 2013-09-19 Release date: 2013-10-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural Basis for the Recognition of Mycolic Acid Precursors by Kasa, a Condensing Enzyme and Drug Target from Mycobacterium Tuberculosis J.Biol.Chem., 288, 2013
3DBM	Crystal Structure of Allene oxide synthase Descriptor: (9E,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid, Cytochrome P450 74A2, PROTOPORPHYRIN IX CONTAINING FE Authors: Li, L, Wang, X. Deposit date: 2008-06-01 Release date: 2008-09-23 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase. Proc.Natl.Acad.Sci.Usa, 105, 2008
1OXH	The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus Pneumoniae, Triclinic form Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION Authors: Price, A.C, Rock, C.O, White, S.W. Deposit date: 2003-04-02 Release date: 2003-04-22 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.09 Å) Cite: The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae. J.Bacteriol., 185, 2003
1TED	Crystal structure of a type III polyketide synthase PKS18 from Mycobacterium tuberculosis Descriptor: MYRISTIC ACID, pks18 Authors: Sankaranarayanan, R, Shanmugam, V.M, Rukmini, R. Deposit date: 2004-05-25 Release date: 2004-08-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.25 Å) Cite: A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites Nat.Struct.Mol.Biol., 11, 2004
1OX0	The crystal structure of beta-ketoacyl-[acyl carrier protein] synthase II from Streptococcus pneumoniae Descriptor: Beta ketoacyl-acyl carrier protein synthase, MAGNESIUM ION Authors: Price, A.C, Rock, C.O, White, S.W. Deposit date: 2003-03-31 Release date: 2003-04-22 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The 1.3-Angstrom-Resolution Crystal Structure of beta-Ketoacyl-Acyl Carrier Protein Synthase II from Streptococcus pneumoniae. J.Bacteriol., 185, 2003
4J7T	Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis Descriptor: D-gamma-glutamyl-S-(4-phenylbutyl)-L-cysteinylglycine, Leukotriene C4 synthase, NICKEL (II) ION, ... Authors: Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. Deposit date: 2013-02-14 Release date: 2014-01-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.203 Å) Cite: Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
4J7Y	Human LTC4 synthase in complex with product analogs - implications for enzyme catalysis Descriptor: D-gamma-glutamyl-(Z)-N-(carboxymethylidene)-S-[(2R)-2-hydroxy-4-phenylbutyl]-L-cysteinamide, Leukotriene C4 synthase, NICKEL (II) ION, ... Authors: Niegowski, D, Rinaldo-Matthis, A, Haeggstrom, J.Z. Deposit date: 2013-02-14 Release date: 2014-01-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.901 Å) Cite: Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM. J.Biol.Chem., 289, 2014
2K0X	The actinorhodin holo acyl carrier protein from S. coelicolor Descriptor: 4'-PHOSPHOPANTETHEINE, Actinorhodin polyketide synthase acyl carrier protein Authors: Crump, M.P, Evans, S.E, Williams, C. Deposit date: 2008-02-15 Release date: 2008-09-16 Last modified: 2021-10-20 Method: SOLUTION NMR Cite: An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein. Chembiochem, 9, 2008
2K0Y	The actinorhodin apo acyl carrier protein from S. coelicolor Descriptor: Actinorhodin polyketide synthase acyl carrier protein Authors: Crump, M.P, Evans, S.E, Christopher, W. Deposit date: 2008-02-15 Release date: 2008-09-16 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein. Chembiochem, 9, 2008
3NE1	Mycobacterium tuberculosis Acyl Carrier Protein Synthase in complex with sulfate ion Descriptor: Holo-[acyl-carrier-protein] synthase, SULFATE ION Authors: Gokulan, K. Deposit date: 2010-06-08 Release date: 2010-07-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.51 Å) Cite: Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations. Acta Crystallogr.,Sect.D, 67, 2011
3NE3	Mycobacterium tuberculosis Acyl Carrier Protein Synthase Apo structure Descriptor: Holo-[acyl-carrier-protein] synthase Authors: Gokulan, K, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB) Deposit date: 2010-06-08 Release date: 2010-07-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations. Acta Crystallogr.,Sect.D, 67, 2011
8GSA	Solution structure of holo acyl carrier protein A from Enterococcus faecalis Descriptor: Acyl carrier protein Authors: Yeon, J, Kim, Y. Deposit date: 2022-09-05 Release date: 2023-03-29 Last modified: 2024-05-08 Method: SOLUTION NMR Cite: Structural study of acyl carrier protein of Enterococcus faecalis and its interaction with enzymes in de novo fatty acid synthesis. Biochem.Biophys.Res.Commun., 637, 2022
1E5M	Beta ketoacyl acyl carrier protein synthase II (KASII) from Synechocystis sp. Descriptor: BETA KETOACYL ACYL CARRIER PROTEIN SYNTHASE II Authors: Moche, M, Edwards, P, Dehesh, K, Lindqvist, Y. Deposit date: 2000-07-27 Release date: 2001-01-16 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.54 Å) Cite: The Crystal Structure of Beta-Ketoacyl-Acyl Carrier Protein Synthase II from Synechocystis Sp. At 1.54 A Resolution and its Relationship to Other Condensing Enzymes J.Mol.Biol., 305, 2001
3TZW	Crystal structure of a fragment containing the acyltransferase domain of Pks13 from Mycobacterium tuberculosis in the orthorhombic apoform at 2.6 A Descriptor: 1,2-ETHANEDIOL, 12-mer peptide, Polyketide synthase PKS13, ... Authors: Bergeret, F, Pedelacq, J.D, Mourey, L, Bon, C. Deposit date: 2011-09-28 Release date: 2012-08-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13 J.Biol.Chem., 287, 2012
5CC5	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-3-carboxylic acid Descriptor: 1H-INDOLE-3-CARBOXYLIC ACID, GLYOXYLIC ACID, MAGNESIUM ION, ... Authors: Huang, H.-L, Sacchettini, J.C. Deposit date: 2015-07-01 Release date: 2016-08-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published
5CC6	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-5-carboxylic acid Descriptor: 1H-indole-5-carboxylic acid, MAGNESIUM ION, Malate synthase G Authors: Huang, H.-L, Sacchettini, J.C. Deposit date: 2015-07-01 Release date: 2016-08-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published
5CC3	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 6-bromo-1H-indole-2-carboxylic acid Descriptor: 6-bromanyl-1H-indole-2-carboxylic acid, MAGNESIUM ION, Malate synthase G Authors: Huang, H.-L, Sacchettini, J.C. Deposit date: 2015-07-01 Release date: 2016-08-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.204 Å) Cite: Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published
5CC7	Crystal structure of Mycobacterium tuberculosis malate synthase in complex with 1H-indole-6-carboxylic acid Descriptor: 1H-indole-6-carboxylic acid, MAGNESIUM ION, Malate synthase G Authors: Huang, H.-L, Sacchettini, J.C. Deposit date: 2015-07-01 Release date: 2016-08-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Crystal structures of fragment-bound malate synthase from Mycobacterium tuberculosis provide insights into mechanism and potential inhibitor designs To Be Published
1DV5	TERTIARY STRUCTURE OF APO-D-ALANYL CARRIER PROTEIN Descriptor: APO-D-ALANYL CARRIER PROTEIN Authors: Volkman, B.F, Zhang, Q, Debabov, D.V, Rivera, E, Kresheck, G.C, Neuhaus, F.C. Deposit date: 2000-01-19 Release date: 2001-08-01 Last modified: 2024-04-10 Method: SOLUTION NMR Cite: Biosynthesis of D-alanyl-lipoteichoic acid: the tertiary structure of apo-D-alanyl carrier protein. Biochemistry, 40, 2001
5IKQ	The Structure of Meclofenamic Acid Bound to Human Cyclooxygenase-2 Descriptor: 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ... Authors: Orlando, B.J, Malkowski, M.G. Deposit date: 2016-03-03 Release date: 2016-05-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. J.Biol.Chem., 291, 2016
5IKV	The Structure of Flufenamic Acid Bound to Human Cyclooxygenase-2 Descriptor: 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ... Authors: Orlando, B.J, Malkowski, M.G. Deposit date: 2016-03-03 Release date: 2016-05-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.508 Å) Cite: Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. J.Biol.Chem., 291, 2016
5IKR	The Structure of Mefenamic Acid Bound to Human Cyclooxygenase-2 Descriptor: 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ... Authors: Orlando, B.J, Malkowski, M.G. Deposit date: 2016-03-03 Release date: 2016-05-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.342 Å) Cite: Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone. J.Biol.Chem., 291, 2016
2UUH	Crystal structure of Human Leukotriene C4 Synthase in complex with substrate glutathione Descriptor: DODECYL-ALPHA-D-MALTOSIDE, GLUTATHIONE, LEUKOTRIENE C4 SYNTHASE, ... Authors: Martinez Molina, D, Wetterholm, A, Kohl, A, McCarthy, A.A, Niegowski, D, Ohlson, E, Hammarberg, T, Eshaghi, S, Haeggstrom, J.Z, Nordlund, P. Deposit date: 2007-03-02 Release date: 2007-07-17 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase. Nature, 448, 2007

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