9BC2
| Transglutaminase 2 - Open State | Descriptor: | CHLORIDE ION, HB-225 (gluten peptidomimetic TG2 inhibitor), Protein-glutamine gamma-glutamyltransferase 2, ... | Authors: | Mathews, I.I, Sewa, A, Khosla, C. | Deposit date: | 2024-04-07 | Release date: | 2024-07-03 | Last modified: | 2024-07-17 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural and mechanistic analysis of Ca 2+ -dependent regulation of transglutaminase 2 activity using a Ca 2+ -bound intermediate state. Proc.Natl.Acad.Sci.USA, 121, 2024
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9B1G
| Human urate transporter 1 URAT1 in complex with dotinurad | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, dotinurad | Authors: | Dai, Y, Lee, C.H. | Deposit date: | 2024-03-13 | Release date: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1. Cell Res., 2024
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9CEQ
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9CJ7
| Lineage IV Lassa virus glycoprotein (Josiah) in complex with monoclonal antibody 8.9F | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Brouwer, P.J.M, Perrett, H.R, Ward, A.B. | Deposit date: | 2024-07-05 | Release date: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses. Cell Rep, 43, 2024
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9CHQ
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9ENE
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9B1I
| Human urate transporter 1 URAT1 in complex with verinurad | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 22 member 12, verinurad | Authors: | Dai, Y, Lee, C.H. | Deposit date: | 2024-03-13 | Release date: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Transport mechanism and structural pharmacology of human urate transporter URAT1. Cell Res., 2024
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9ENF
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9F2K
| Myo-inositol-1-phosphate synthase from Thermochaetoides thermophila in complex with NAD | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, inositol-3-phosphate synthase | Authors: | Traeger, T.K, Kyrilis, F.L, Hamdi, F, Kastritis, P.L. | Deposit date: | 2024-04-23 | Release date: | 2024-08-14 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Disorder-to-order active site capping regulates the rate-limiting step of the inositol pathway. Proc.Natl.Acad.Sci.USA, 121, 2024
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9ILB
| HUMAN INTERLEUKIN-1 BETA | Descriptor: | PROTEIN (HUMAN INTERLEUKIN-1 BETA) | Authors: | Yu, B, Blaber, M, Gronenborn, A.M, Clore, G.M, Caspar, D.L.D. | Deposit date: | 1998-10-22 | Release date: | 1999-01-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography. Proc.Natl.Acad.Sci.USA, 96, 1999
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9IWQ
| Salmonella enterica serovar Typhimurium FliC(G426A)delta(204-292) forming the L-type straight filament | Descriptor: | Flagellin | Authors: | Waraich, K, Makino, F, Miyata, T, Kinoshita, M, Minamino, T, Namba, K. | Deposit date: | 2024-07-25 | Release date: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (2.08 Å) | Cite: | Salmonella enterica serovar Typhimurium FliC(G426A)delta(204-292) forming the L-type straight filament To Be Published
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9D9X
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9IUY
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9BEW
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8Z1L
| Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant atomoxetine in an outward-open state at resolution of 3.4 angstrom. | Descriptor: | (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine, CHLORIDE ION, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2024-04-11 | Release date: | 2024-07-31 | Last modified: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632, 2024
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9BKD
| The structure of human Pdcd4 bound to the 40S small ribosomal subunit | Descriptor: | 18S rRNA, 40S ribosomal protein S12, 40S ribosomal protein S13, ... | Authors: | Brito Querido, J, Sokabe, M, Diaz-Lopez, I, Gordiyenko, Y, Zuber, P, Albacete-Albacete, L, Ramakrishnan, V, S.Fraser, C. | Deposit date: | 2024-04-27 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit. Nat Commun, 15, 2024
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8YWX
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8ZHD
| SARS-CoV-2 spike trimer (6P) in complex with two R1-26 Fabs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, ... | Authors: | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | Deposit date: | 2024-05-10 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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9AWJ
| Bovine adult muscle nAChR bound to ACh | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, ... | Authors: | Li, H, Hibbs, R.E. | Deposit date: | 2024-03-05 | Release date: | 2024-07-31 | Last modified: | 2024-09-18 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Structural switch in acetylcholine receptors in developing muscle. Nature, 632, 2024
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9CTS
| Best1 + GABA intermediate state 2 | Descriptor: | Bestrophin-1, CALCIUM ION, GAMMA-AMINO-BUTANOIC ACID | Authors: | Owji, A.P, Kittredge, A, Zhang, Y, Yang, T. | Deposit date: | 2024-07-25 | Release date: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel. Nat Commun, 15, 2024
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9FWG
| LSD1/CoREST bound to bomedemstat | Descriptor: | Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1 | Authors: | Speranzini, V, Mattevi, A. | Deposit date: | 2024-06-30 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84, 2024
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8ZLE
| hAE3NTD2TMD with PT5,CLR, and Y01 | Descriptor: | CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate, ... | Authors: | Jian, L, Zhang, Q, Yao, D, Wang, Q, Xia, Y, Qin, A, Cao, Y. | Deposit date: | 2024-05-19 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | The structural insight into the functional modulation of human anion exchanger 3. Nat Commun, 15, 2024
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9FAC
| Additional cryo-EM structure of cardiac amyloid AL59 - mixed polymorph | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Monoclonal immunoglobulin light chains (LC) | Authors: | Schulte, T, Speranzini, V, Chaves-Sanjuan, A, Milazzo, M, Ricagno, S. | Deposit date: | 2024-05-10 | Release date: | 2024-08-14 | Last modified: | 2024-08-28 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis. Nat Commun, 15, 2024
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9B1N
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8ZHL
| SARS-CoV-2 spike trimer (6P) in complex with two H18 and two R1-32 Fabs | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | Authors: | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | Deposit date: | 2024-05-11 | Release date: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein helping to drive the genesis of Omicron variants To Be Published
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