8YWX

the complex structure of the H4B6 Fab with the RBD of Omicron BA.5 S protein

Summary for 8YWX

• Entry DOI: 10.2210/pdb8ywx/pdb
• EMDB information: 39646
• Descriptor: H4B6 Fab's heavy chain, H4B6 Fab's light chain, Spike protein S2' (3 entities in total)
• Functional Keywords: antibody, viral protein/immune system, viral protein-immune system complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 223945.10

Authors

Xia, L.Y.,Zhang, Y.Y.,Zhou, Q. (deposition date: 2024-04-01, release date: 2024-07-31)

• Primary citation: Sun, H.,Xia, L.,Li, J.,Zhang, Y.,Zhang, G.,Huang, P.,Wang, X.,Cui, Y.,Fang, T.,Fan, P.,Zhou, Q.,Chi, X.,Yu, C.; A novel bispecific antibody targeting two overlapping epitopes in RBD improves neutralizing potency and breadth against SARS-CoV-2.; Emerg Microbes Infect, 13:2373307-2373307, 2024; PubMed: 38953857; DOI: 10.1080/22221751.2024.2373307

Experimental method

ELECTRON MICROSCOPY (3.4 Å)