PDB: 334 resultsInfo pagesStatus searchChemie searchBIRD

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4ZH2	Crystal structure of Escherichia coli RNA polymerase in complex with CBR703 Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Feng, Y, Ebright, R.H. Deposit date: 2015-04-24 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (4.204 Å) Cite: Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
4XLR	Crystal structure of T.aquaticus transcription initiation complex with CarD containing bubble promoter and RNA Descriptor: CarD-like transcriptional regulator, DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-13 Release date: 2015-09-23 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (4.3 Å) Cite: CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
4XLN	Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA Descriptor: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-13 Release date: 2015-09-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4 Å) Cite: Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
7YE1	The cryo-EM structure of C. crescentus GcrA-TACup Descriptor: Cell cycle regulatory protein GcrA, DNA (57-MER)-non template, DNA (57-MER)-template, ... Authors: Wu, X.X, Zhang, Y. Deposit date: 2022-07-05 Release date: 2023-01-18 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Cryo-EM structures of Caulobacter crescentus transcription activation complex with an essential cell cycle regulator GcrA Nucleic Acids Res., 2023
7YE2	The cryo-EM structure of C. crescentus GcrA-TACdown Descriptor: Cell cycle regulatory protein GcrA, DNA (90-MER)-non template, DNA (90-MER)-template, ... Authors: Wu, X.X, Zhang, Y. Deposit date: 2022-07-05 Release date: 2023-01-18 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Cryo-EM structures of Caulobacter crescentus transcription activation complex with an essential cell cycle regulator GcrA Nucleic Acids Res., 2023
7W5Y	Cryo-EM structure of SoxS-dependent transcription activation complex with fpr promoter DNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Lin, W, Feng, Y. Deposit date: 2021-11-30 Release date: 2022-10-26 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural basis of three different transcription activation strategies adopted by a single regulator SoxS. Nucleic Acids Res., 50, 2022
7VPD	Cryo-EM structure of Streptomyces coelicolor RNAP-promoter open complex with one Zur dimers Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2021-10-15 Release date: 2022-08-03 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.77 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
7VPZ	Cryo-EM structure of Streptomyces coelicolor transcription initial complex with one Zur dimer Descriptor: DNA (84-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Yang, X, Zheng, J. Deposit date: 2021-10-18 Release date: 2022-08-03 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (4.14 Å) Cite: Structural basis of Streptomyces transcription activation by zinc uptake regulator. Nucleic Acids Res., 50, 2022
4YLP	E. coli Transcription Initiation Complex - 16-bp spacer and 5-nt RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zuo, Y, Steitz, T.A. Deposit date: 2015-03-05 Release date: 2015-04-22 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (5.5 Å) Cite: Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
4YG2	X-ray crystal structur of Escherichia coli RNA polymerase sigma70 holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Murakami, K.S. Deposit date: 2015-02-25 Release date: 2015-03-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.7 Å) Cite: X-ray crystal structure of Escherichia coli RNA polymerase sigma70 holoenzyme J. Biol. Chem., 288, 2013
7XYA	The cryo-EM structure of an AlpA-loading complex Descriptor: AlpA, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Wen, A, Feng, Y. Deposit date: 2022-06-01 Release date: 2022-07-20 Last modified: 2022-08-24 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis of AlpA-dependent transcription antitermination. Nucleic Acids Res., 50, 2022
4YLN	E. coli Transcription Initiation Complex - 17-bp spacer and 4-nt RNA Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Zuo, Y, Steitz, T.A. Deposit date: 2015-03-05 Release date: 2015-04-22 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (5.5 Å) Cite: Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
7XUI	Cryo-EM structure of sigma70 bound HK022 putRNA-associated E.coli RNA polymerase elongation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Hwang, S, Kang, J.Y. Deposit date: 2022-05-18 Release date: 2022-08-10 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.61 Å) Cite: Structural basis of transcriptional regulation by a nascent RNA element, HK022 putRNA. Nat Commun, 13, 2022
4YFX	Escherichia coli RNA polymerase in complex with Myxopyronin B Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. Deposit date: 2015-02-25 Release date: 2015-03-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.844 Å) Cite: X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4YFK	Escherichia coli RNA polymerase in complex with squaramide compound 8. Descriptor: 3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. Deposit date: 2015-02-25 Release date: 2015-03-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (3.571 Å) Cite: X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4XLS	Crystal structure of T. aquaticus transcription initiation complex with CarD containing upstream fork promoter. Descriptor: CarD-like transcriptional regulator, DNA (30-MER), DNA (5'-D(P*GP*CP*AP*CP*AP*AP*TP*TP*TP*AP*AP*CP*AP*CP*TP*TP*TP*TP*GP*TP*CP*AP*AP*G)-3'), ... Authors: Bae, B, Darst, S.A. Deposit date: 2015-01-13 Release date: 2015-09-23 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (4.01 Å) Cite: CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
7ZF2	Protomeric substructure from an octameric assembly of M. tuberculosis RNA polymerase in complex with sigma-b initiation factor Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Trapani, S, Bron, P, Lai Kee Him, J, Brodolin, K, Morichaud, Z, Vishwakarma, R. Deposit date: 2022-03-31 Release date: 2023-02-08 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.86 Å) Cite: Structural basis of the mycobacterial stress-response RNA polymerase auto-inhibition via oligomerization. Nat Commun, 14, 2023
6CA0	Cryo-EM structure of E. coli RNAP sigma70 open complex Descriptor: DNA (35-MER), DNA (45-MER), DNA (5'-D(P*GP*CP*CP*GP*CP*GP*TP*CP*AP*GP*A)-3'), ... Authors: Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yernool, D, Jiang, W, Murakami, K.S. Deposit date: 2018-01-29 Release date: 2018-02-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.75 Å) Cite: Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation. J. Biol. Chem., 293, 2018
6DCF	Crystal structure of a Mycobacterium smegmatis transcription initiation complex with Rifampicin-resistant RNA polymerase and bound to kanglemycin A Descriptor: 1,2-ETHANEDIOL, DNA (26-MER), DNA (31-MER), ... Authors: Lilic, M, Darst, S.A, Campbell, E.A. Deposit date: 2018-05-06 Release date: 2018-09-05 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.45 Å) Cite: Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Nat Commun, 9, 2018
6TYF	Crystal structure of MTB sigma L transcription initiation complex with 6 nt long RNA primer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Ebright, R.H. Deposit date: 2019-08-08 Release date: 2020-03-11 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6TYG	Crystal structure of MTB sigma L transcription initiation complex with 9 nt long RNA primer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Ebright, R.H. Deposit date: 2019-08-08 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.5 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020
6DVD	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) with 6 nt spacer and bromine labelled in position "-11 Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*A)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2018-06-23 Release date: 2019-02-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.899 Å) Cite: Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
6DV9	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF sigma factor L) containing 5nt RNA with 4nt spacer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*CP*AP*GP*AP*GP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2018-06-23 Release date: 2019-02-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
6DVE	Crystal structure of Mycobacterium tuberculosis transcription initiation complex(ECF selenomethionine-labelled sigma factor L) with 6 nt spacer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*T)-3'), DNA (5'-D(P*CP*GP*TP*GP*TP*GP*AP*GP*TP*AP*AP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Lin, W, Das, K, Feng, Y, Ebright, R.H. Deposit date: 2018-06-23 Release date: 2019-02-20 Last modified: 2019-02-27 Method: X-RAY DIFFRACTION (3.812 Å) Cite: Structural basis of ECF-sigma-factor-dependent transcription initiation. Nat Commun, 10, 2019
6TYE	Crystal structure of MTB sigma L transcription initiation complex with 5 nt long RNA primer Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ... Authors: Molodtsov, V, Ebright, R.H. Deposit date: 2019-08-08 Release date: 2020-03-11 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.79 Å) Cite: RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription. Proc.Natl.Acad.Sci.USA, 117, 2020

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